Memory Enhancing Effect of Ethanolic Extract of Stevia rebaudiana (Bert.)

Authors

  • Divya S Juyal Department of Pharmacy, Kumaun University, Bheemtal (Nainital), Uttrakhand, India 263631.
  • Ganga Bisht Department of Chemistry, Kumaun University, Nainital, Uttrakhand, India 263631.
  • Arun Kumar Department of Pharmacy, Kumaun University, Bheemtal (Nainital), Uttrakhand, India 263631.

Keywords:

Stevia rebaudiana, Memory, Alzheimer disease

Abstract

Suspension of ethanolic extract of leaves of Stevia rebaudiana bert. in gum acacia were administered orally to evaluate the memory enhancing activity in the aged rats. Memory enhancing effect was evaluated by using Morris water maze and elevated plus maze. Mean escape latency time (ELT) calculated each day during acquisition trial was used as an index of acquisition and mean time spent in target quadrant in search of missing platform provided an index of retrieval. Significant reduction in transfer latency (TL) value of retention indicated improvement of memory. Significant memory enhancing effect of ethanolic extract Stevia rebaudiana was observed in aged rats at 200 mg/kg p.o. dose.

References

Michelle CJ, Michael AM, Salvatore O,

Frank ML, Howard JF, William JB. Early

correlation of microgilal activation with

enhanced tumor necrosis factor-alpha and

monocyte chemoattractant protein-1

expression specifically with in the

entorhinal cortex of triple transgenic

Alzheimer disease mice. Journal of

neuroinflammation 2005; 2:23-26.

Tamar A, Yael AT, Moussa BHY, Silvia

M. Targeting multiple Alzheimer’s

Disease etiologies with multimodal

neuroprotective and neurorestorative iron

chelators. FASEB 2008;22:1296-1305.

McGeer PL, McGeer EG. Polymorphism

in inflammatory genes and the risk of

Alzheimer disease. Archives of

Neurology 2001;58:1790-1792.

Colin KC, Derrick EJ, Kario JC, Steven

BC, Gary EL. Inflammatory mechanism

in Alzheimer’s disease: Inhibition of beta

amyloid stimulated proinflammatory

responses and neuro toxicity by PPARgama agonist. The Journal of

Neuroscience 2000;20(2):558-567.

Mark AS, Catherine AR, Akihiko N,

Arun KR, George P. Oxidative stress in

Alzheimer’s disease. Biochimica et

Biophysica Acta 2000;1502:139-144.

Veurink G, Fullers SJ, Atwood CS,

Martins RN. Genetic, lifestyle and roles

of amyloid beta and oxidative stress in

Alzheimer’s disease. Annals of Human

Biology 2003;30(6) 639-667.

Sulkava R. Anti-inflammatory drug

therapy for prevention of Alzheimer’s

disease. Duodecim 1998;114:2025-2027.

Wood AJJ. Drug therapy : Alzheimer’s

disease. N. Engl. J. Med. 2004;351:56-67.

Jan MC. Stevioside. Phytochemistry

;64:913-921.

Soni S, Kondalkar A, Tailang M, Pathak

AK. Pharmacognistic and phytochemical

investigation on Stevia rubadiana. Phcog

Mag. 2008; 4(13):89-94.

Kennelly EJ. Sweet and non-sweet

constitute of Stevia rubadiana (Bertoni)

bertoni. Kinghorn AD. Editor In the

genous of stevia Vol 19, Taylor and

Francis, London and NY 2002. pp 68-85

Starrat AN, Kirby CW, Pocs R, Brandle

JE. Rebaudioside F, a diterpene

glycoside from Stevia rubadiana.

Phytochemistry 2002;59:367-370.

Murali B, Upadhyaya UM, Goyal RK.

Effect of chronic treatment with

enicostemma littorale in non-insulindependent diabetic (NIDDM) rats. J.

Ethanopharmacol 2002;81:199-204.

Akiyma H, Barger S, Barnum S, Bradt B,

Bauer J, Cole GM, Cooper NR,

Eikelenboom P, Emmerling M, Fiebich

BL, Finch CE, Frautschy S, Griffin WS,

Hampel H, Hull M, Landreth G, Lue L,

Mrak R, Mackenzie IR, McGeer PL.

Inflammation and Alzheimer’s disease.

Neurobio. Aging 2000;21:383-421.

Berr C. Oxidative stress and cognitive

impairment in the elderly. J. Nutr.

Health Aging. 2002;6:261-266.

Floyd RA, Hensly K. Oxidative stress in

brain aging. Implication for

therapeutics of neurogenerative disease.

Neurobil. Aging 2002;23:795-807.

Harman D. Aging: A theory based on

free radical and radiation chemistry.

Journal of Gerontal 1956;11:298-300.

Harmanal. A hypothesis on the

pathogenesis of AD. Ann NY ACad

Science 1996;786: 152-168.

Takatsu H, Owada K, Abe L, Natano M,

Urans S. Effect of vitamin E on

learning and memory deficit in aged

rats. Journal of Nutration Science

Vitaminal 2009;55:389-393.

Gumieniczek A, Hopkala H, Roliñski J,

Bojarska-Junak A. Antioxidative and

anti-inflammatory effects of repaglinide

in plasma of diabetic animals.

Pharmacol Res 2005;52:162–6.

Tuttle HA, Davis-Gorman G, Goldman S,

Copeland JG, McDonagh PF.

Proinflammatory cytokines are increased

in type 2 diabetic women with

cardiovascular disease. J Diabet

Complications 2004;18:343–51.

Stephan A, Laroche S, Davis S.

Learning defects and dysfunctional

synaptic plasticity induced by

aggregated amyloid deposits in the

dentate gyrus are reduced by chronic

treatment with indomethacin. Eur. J.

Neurosci. 2003;17: 1921-1927.

Ibrahim NA, Motaw H, Riad SA.

Phytochemical and biological

investigation of Stevia rubadiana

(Bertoni). European Food Research and

Technology 2007;224 :483-488.

Brunet J, Farine JC, Garay RP, Hannaert

P. Invitro antioxidant properties of

calcium dobesilate. Clin. Pharmacol.

;12: 205-212.

Morris KA, Chang Q, Mohler, EG, Gold

PE. Age related memory Impairment

due to reduced blood glucose responses to

epinephrine Neurobilogy of Aging

;1-10..

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Published

30-06-2010

How to Cite

1.
Divya S Juyal, Ganga Bisht, Arun Kumar. Memory Enhancing Effect of Ethanolic Extract of Stevia rebaudiana (Bert.). ijp [Internet]. 2010 Jun. 30 [cited 2024 Jun. 21];2(2):166-71. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/34

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Original Research Articles