International Journal of Phytomedicine

Formulation, Characterisation and Preclinical evaluation of Antidiabetic activity of Polyherbal tablet

2022-02-26T23:28:58+0530

Diabetes mellitus is a complex and a diverse group of disorders that disturbs the metabolism of carbohydrate, fat and protein. The number of diabetes mellitus cases has been increasing worldwide in recent years. In 2000, the WHO estimated a total of 171 million people with diabetes mellitus from the global population, and this report projected to increase to 366 million by 2030. Now a days polyherbal formulations made by a different herbal pharmaceutical company is very much popular and acceptable for chronic use in case of diabetes, hypertension, bronchial asthma, hyperlipidemia, rheumatoid arthritis, etc. As the incidence of diabetes is increasing day by day globally, and the rate of occurrence of disease in India is tho high, the popularity of polyherbal formulation is increasing day by day. many physicians from a different system of medicine refer to advice polyherbal formulations for long time use in patient of diabetes, as the manufacturer of herbal formulator claim the formulation is having a negligible side effect. Present Study was delt with Evaluation of antihyperglycemic Potential of prepared polyherbal Formulation PHF i.e. with 1mg/kg and 1.5 mg/kg, the FBS level was reduced from 187.16 ± 3.25 to 133.16 ± 2.93 and 181.5 ± 4.42 to 136.33 ± 2.58, respectively. In the combination regimen of PHF (1.5mg/kg) and Metformin (50mg/kg) the mean FBS level dropped from 180.3 ± 1.75 to 131.16 ± 2.14. In all these groups the mean FBS level has reached the normal pre-induction level. The daily single administration of PHFformulation(1.5mg/kg) and Metformin (50 mg/kg) significantly reduced blood sugar levels of Streptozotocin (STZ) induced diabetic mice. It also important to study antihyperglycemic effect of the said Polyhedral Formulation in Different animal Model to conclude exact pattern of Anti hyperglycaemic activity.

Potential antioxidant and hypoglycaemic effect of the flower extract of Bougainvillea spectabilis Willd. (Nyctaginaceae)

2022-02-26T23:30:55+0530

The study evaluated the antioxidant and hypoglycaemic potentials of the ethanol flower extract of Bougainvillea spectabilis. Flower extract of Bougainvillea spectabilis were obtained by cold maceration method. The preliminary phytochemical screening and hypoglycaemic effect were carried out using standard methods. Antioxidant screening was carried out using DPPH antioxidant assay test. Five rats were used for each group; normal control, standard control, 100, 200 and 400 mg/kg b.w. doses of the crude ethanol flower extract of B. spectabilis to test the hypoglycaemic effect in alloxan-induced diabetic rats. Blood glucose levels were measured at different time intervals. The preliminary phytochemical screening revealed the presence of alkaloids, saponins, strerols, terpenoids, flavonoids, and carbohydrates. The crude ethanol fraction demonstrated least antioxidant activity while the chloroform fraction showed the highest antioxidant activity followed by the hexane fraction. The ethanol flower extract showed a significant dose dependent hypoglyceamic effect after 24 hours of administration. Of the doses tested, highest hypoglycaemic effect was observed by the ethanol flower extract of the dose 400 mg/kg at 24 hours. The findings revealed that non-polar fractions have more antioxidant activity than the polar fractions while the ethanol flower extract of Bougainvillea spectabilis possesses a delayed hypoglycaemic effect.

Curcumin loaded Solid lipid nanoparticles enhanced efficacy in vascular dementia against Homocysteine induced toxicity

2022-02-26T23:35:15+0530

Vascular dementia (VaD), a diverse group of brain disorders with cognitive decline is attributable to cerebrovascular pathologies. Recent studies have shown that mitochondrial dysfunctions and oxidative stress are involved in cognitive decline. The aim of the present study was designed to evaluate the effects of Curcumin loaded solid lipid nanoparticles (Cur-SLNP) in vascular dementia (VaD) against homocystiene (HCY) induced toxicity by behavioral and biochemical assessment in different regions of the brain. The sign of VaD i.e., learning and memory levels were evaluated with different behavioural assessment like plus maze test. Neurobehavioral analyses revealed that Cur-SLNP administration successfully ameliorated cognitive decline observed in HCY rats. Compared to HCY administration, Cur-SLNP 10 mg/kg and 25 mg/kg administration showed ameliorative effect in behavioural and biochemical assessment induced by HCY. We found that lipid peroxidation levels decreased significantly in striatum (p<0.01), cortex (p<0.001), and hippocampus (p<0.001) after oral administration of Cur-SLNP with HCY animals. Hence, the present findings suggest that the neuroprotective role of Cur-SLNP against HCY induced toxicity could be a novel and promising therapeutic strategy in VaD as well in other age-related neurodegenerative disorders.

Herbal Medicines in management and prevention of COVID-19

2022-02-26T23:24:30+0530

Traditional herbal medicines are widely accepted in the world. Certain countries and WHO have research investment in traditional herbal medicines. COVID-19 came as a major Health care challenge for human in 2019. 480 deaths have been recorded till 18th of April 2020 in India. No pharmaceutical products have yet been shown to be safe and effective for the treatment of COVID-19. Major 3 types of targets of COVID-19 were identified by researches, which are as follow – 1) Inhibit coronavirus at structural level, 2) Inhibit coronavirus RNA synthesis and replication and 3) Inhibit virulence factor of Coronavirus. Certain Herbal medicines like Tribulus terrestris, Withania somnifera, Curcuma longa, Ocimum sanctum, and Phyllanthus emblica have potent Anti-COVID properties, which is indicating new sunrise in the direction of Herbal medicine.