Anti-α-glucosidase and antiglycation activities of galls from Guiera senegalensis J.F. Gmel (combretaceae)

Authors

  • Pierre Alexandre Eric Djifaby SOMBIE Institute of Environment and Agricultural Research, 01 BP 476 Ouagadougou 01
  • Rahman M HAFIZUR International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
  • Moussa COMPAORÉ Laboratory of Biochemistry and Chemistry Applied (LABIOCA), University of Ouaga I Professor Joseph Ki-Zerbo, Ouagadougou, 03 BP 7021 Ouagadougou 03
  • Martin KIENDREBEOGO Laboratory of Biochemistry and Chemistry Applied (LABIOCA), University of Ouaga I Professor Joseph Ki-Zerbo, Ouagadougou, 03 BP 7021 Ouagadougou 03
  • Muhammad Iqbal CHOUDHARY Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
  • Odile Germaine NACOULMA Laboratory of Biochemistry and Chemistry Applied (LABIOCA), University of Ouaga I Professor Joseph Ki-Zerbo, Ouagadougou 03 BP 7021 Ouagadougou 03 Burkina Faso

Keywords:

Guiera senegalensis, Galls, α-Glucosidase, Antiglycation, α-chymotrypsin

Abstract

The hypoglycemic activity of Guiera senegalensis used in Burkinabe folk medicine has been already reported. The aim of this study was to investigate the in vitro antidiabetic activity from galls of G.senegalensis. The extracts and methanol fractions from galls of G. senegalensis showed strong α-glucosidase inhibitory activity compared with acarbose. The ethyl acetate fraction from methanol extract (EA/ME) showed potent antiglycation activity in an in vitro assay system. The galls did not show inhibition activity against α-chymotrypsin. The α-glucosidase inhibitory activity along with its antiglycation activity may open a new perspective for the use of G. senegalensis for the diabetic subject. The data suggests that consumption of G senegalensis galls as an infusion or in food and pharmaceutical preparations may be useful for the management of diabetes and its complications.

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Published

30-06-2018

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1.
Pierre Alexandre Eric Djifaby SOMBIE, Rahman M HAFIZUR, Moussa COMPAORÉ, Martin KIENDREBEOGO, Muhammad Iqbal CHOUDHARY, Odile Germaine NACOULMA. Anti-α-glucosidase and antiglycation activities of galls from Guiera senegalensis J.F. Gmel (combretaceae). ijp [Internet]. 2018 Jun. 30 [cited 2024 Jun. 23];10(2):81-6. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/593

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