Phytochemical and pharmacological investigation of Teucrium muscatense

Authors

  • Najeeb Ur Rehman UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa-616, Sultanate of Oman
  • Jawaher Mohammad Salim Al-Sahai UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa-616, Sultanate of Oman
  • Hidayat Hussain UoN Chair of Oman’s Medicinal Plants and Marine Natural Products University of Nizwa P.O Box 33, Postal Code 616 Birkat Al Mauz, Nizwa, Sultanate of Oman
  • Abdul Latif Khan UoN Chair of Oman’s Medicinal Plants and Marine Natural Products University of Nizwa P.O Box 33, Postal Code 616 Birkat Al Mauz, Nizwa, Sultanate of Oman
  • Syed Abdullah Gilani Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al Mauz, Nizwa-616, Sultanate of Oman
  • Ghulam Abbas Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al Mauz, Nizwa-616, Sultanate of Oman
  • Javid Hussain Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al Mauz, Nizwa-616, Sultanate of Oman
  • Jamal Nasser Sabahi Central Instrument Laboratory, College of Agriculture and Marine Sciences, Sultan Qaboos University, Sultanate of Oman
  • Ahmed Al-Harrasi 1. UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Nizwa-616, Sultanate of Oman 2. Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al Mauz, Nizwa-616, Sultanate of Oman

Keywords:

Teucrium muscatense, flavonoids, GC/MS, anti-cancer, biological activities

Abstract

The effect of enzyme inhibition, anticancer, antifungal, antioxidants activities of the extracts of Teucrium muscatense obtained with different organic solvents was investigated. Chloroform fraction exhibited promising inhibition (64%) with IC50 value (390 ± 2.0 μg/mL) against urease, while other fractions displayed moderate activity. In case of α-glucosidase and acetyl cholinesterase enzyme inhibition assays, all fractions were found inactive at a concentration of 1.0 mg/mL. The n-hexane fraction of Teucrium muscatense exhibited highest anticancer activity against breast cancer cell (MDAMB231) line at high (100 µg/mL) concentration and also inhibited the growth of F. oxysporum up to 64.3% in case of antifungal activity. EtOAc fraction showed highiest DPPH (70.6%) and ABTS (76.7%) radical scavenging activity at highest concentration (1000 μg/mL). Bioassay guided isolation of EtOAc fraction afforded two flavonoids (1 and 2). Both compounds showed highiest ABTS activity and could be a significant markers in the EtOAc fraction. Anti-lipid peroxidation assay was also performed in which aqueous fraction showed highest percentage of 73.2% at higher concentration (1000 μg/mL) followed by n-BuOH (64.1%) and EtOAc (51.4%) fractions. GC/MS analysis of the essential oil of T. mascatense showed higher percentage of linalool (34.18%), limonene (13.45%), linalyl acetate (10.04%), and β-eudesmol (9.21%). Proximate composition of Teucrium muscatense showed that it contained high amount of ash (19.6%), protein (10.3%), and fiber (17.5%).

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Published

31-12-2016

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1.
Najeeb Ur Rehman, Jawaher Mohammad Salim Al-Sahai, Hidayat Hussain, Abdul Latif Khan, Syed Abdullah Gilani, Ghulam Abbas, Javid Hussain, Jamal Nasser Sabahi, Ahmed Al-Harrasi. Phytochemical and pharmacological investigation of Teucrium muscatense. ijp [Internet]. 2016 Dec. 31 [cited 2024 Dec. 7];8(4):567-79. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/505

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