A phytopharmacological review on an Arabian medicinal plant: Caralluma flava N.E.Br
Keywords:
Caralluma flava, pregnane glycoside, anticancer activity, Desmidorchis flavaAbstract
Caralluma flava (N.E.Br.) is a medicinal plant which is gaining renowned attention in scientific community due to its potential curative powers. Traditionally, it is used in Arab regions as an anti-diabetic and anti-ulcer. It is also used as an anti-inflammatory, anti-parasitic and anti-pyretic. Due to its pharmacological values, initial biological activities of C. flava have been carried out recently and some pregnane glycoside molecules have been isolated and identified from its sap. The plant lacks the reports of phytochemical studies and pharmacological activities which support its further investigation and validation of the traditional therapeutic claims. The compiled data in this review is intended to serve as a reference to many researchers and may help them to focus on the priority areas of research yet to be discovered.
References
. Feulner GR. The Olive Highlands: A unique island of biodiversity within the Hajar Mountains of the United Arab Emirates. Tribulus. 2014;22:9-35.
. Mosti S, Raffaelli M, Tardelli M. Contribution to the flora of central southern Dhofar (Sultanate of Oman). Webbia. 2012;67(1):65-91. DOI: 10.1080/00837792.2012.10670909
. Ghazanfar SA. Status of the flora and plant conservation in the Sultanate of Oman. Biol. Cons. 1998;85(3):287-95. DOI: 10.1016/S0006-3207(97)00162-6
. Bruyns PV, Jonkers HA. The genus Caralluma R.Br. (Asclepiadaceae) in Oman. Bradleya. 1993;11:51-69. DOI: 10.25223/brad.n11.1993.a3
. Patzelt A. Oman plant: Red Data Book. Muscat, Oman: Oman botanic Garden; 2015.
. Miller AG, Morris M. Plants of Dhofar: the southern region of Oman, traditional, economic and medicinal uses. Oman: Office of the Adviser for Conservation of the Environment, Diwan of Royal Court Sultanate of Oman; 1988. p. 52.
. Formisano C, Senatore F, Della Porta G, Scognamiglio M, Bruno M, Maggio A, Rosselli S, Zito P, Sajeva M. Headspace volatile composition of the flowers of Caralluma europaea N.E.Br. (Apocynaceae). Molecules. 2009;14(11):4597-613. DOI: 10.3390/molecules14114597
. Jürgens A, Dötterl S, Meve U. The chemical nature of fetid floral odours in stapeliads (Apocynaceae-Asclepiadoideae‐Ceropegieae). New Phytol. 2006;172(3):452-68. DOI: 10.1111/j.1469-8137.2006.01845.x
. Raees MA: Phytochemical investigation on the chemical constituents of Caralluma flava. Ph.D. Thesis. Federal Urdu University of Arts, Science and Technology, Chemistry Department; 2017.
. Mosti S, Raffaelli M. Desmidorchis tardellii (Asclepiadaceae), a new species from Dhofar, southern Oman. Webbia. 2004;59(2):285-91. DOI: 10.1080/00837792.2004.10670773
. Baker JG. Botany of the Hadramaut expedition. Bull. Misc. Inform. Kew. 1894;1894:328-43. DOI: 10.2307/4118301
. Albers F, Meve U. Illustrated Handbook of Succulent Plants: Asclepiadaceae. Springer Science & Business Media; 2004 DOI:10.1007/978-3-642-56370-6
. Bruyns PV, Jonkers HA. The genus Caralluma R.Br. (Asclepiadaceae) in Oman. Bradleya. 1993 Feb;11:51-69. DOI: 10.25223/brad.n11.1993.a3
. Al-Naqeb G. Acute toxicity and anti-ulcerative potential of Caralluma flava N.E.Br. methanolic extract against ethanol-induced gastric ulcers in rats. J. Med. Plants. Stud. 2017;5(6):21-5.
. Al-Naqeb G. Caralluma flava N.E.Br. extract reduces plasma glucose level and improves plasma antioxidant enzymes in hyperglycemic rats. J. Med. Plants. Stud. 2017;5(6):39-43.
. Divakar MC, Al-Siyabi A, Varghese SS, Al Rubaie M. The practice of ethno-medicine in the Northern & Southern provinces of Oman. Oman Med. J. 2016 Jul;31(4):245. DOI: 10.5001/omj.2016.49
. Ghazanfar SA. Handbook of Arabian medicinal plants. CRC press; 1994 Aug 24. DOI: 10.1201/b14834
. Adnan M, Jan S, Mussarat S, Tariq A, Begum S, Afroz A, Shinwari ZK. A review on ethnobotany, phytochemistry and pharmacology of plant genus Caralluma R.Br. J. Pharm. Pharmacol. 2014;66(10):1351-68. DOI: 10.1111/jphp.12265
. Dutt HC, Singh S, Avula B, Khan IA, Bedi YS. Pharmacological review of Caralluma R.Br. with special reference to appetite suppression and anti-obesity. J. Med. food. 2012;15(2):108-19. DOI: 10.1089/jmf.2010.1555
. Raees MA, Hussain H, Rehman NU, Khan HY, Abbas G, Al-Rawahi A, Elyassi A, Al-Amri IS, Green IR, Al-Broumi MA, Mahmood T. Desmiflavasides A and B: Two new bioactive pregnane glycosides from the sap of Desmidorchis flava. Phytochem. Lett. 2015;12:153-7. DOI:10.1016/j.phytol.2015.03.013
. Raees MA, Hussain H, Al-Rawahi A, Csuk R, Muhammad SA, Khan HY, Rehman NU, Abbas G, Al-Broumi MA, Green IR, Elyassi A. Anti-proliferative and computational studies of two new pregnane glycosides from Desmidorchis flava. Bioorg. Chem. 2016;67:95-104. DOI: 10.1016/j.bioorg.2016.05.008
. Hussain H, Raees MA, Rehman NU, Al-Rawahi A, Csuk R, Khan HY, Abbas G, Al-Broumi MA, Green IR, Elyassi A, Mahmood T. Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava. Arch. Pharm. Res. 2015;38(12):2137-42. DOI: 10.1007/s12272-015-0653-0
. Raees MA, Hussain H, Al-Rawahi A, Csuk R, Al-Ghafri A, Rehman NU, Elyassi A, Green IR, Mahmood T, Al-Harrasi A. Desflavasides A-D: Four new tetrasaccharide pregnane glycosides from Desmidorchis flava. Phytochem. Lett. 2016;16:230-5. DOI: 10.1016/j.phytol.2016.04.012
. Karthishwaran K, Shamisi SO, Kurup SS, Sakkir S, Cheruth AJ. Free radical scavenging and antioxidant capacities with special emphasis on enzyme activities and in-vitro studies in Caralluma flava N.E.Br. Biotechnol. Biotechnol. Equip. 2017:1-7. DOI: 10.1080/13102818.2017.1379362
