Ethanobotanical, phytochemical and pharmacological properties of Zizyphus nummularia (Burm. F.): A Review
Keywords:
Chhoti ber, Cyclopeptide alkaloids, Nummularine, Zizyphus nummulariaAbstract
Zizyphus nummularia (Burm. F.), Family: Rhamnaceae, is widely distributed in dry regions of India. It is a bushy weed used as folk medicine. The plant is valued for its nutritional edible fruits. Traditionally, it is used in mental retardation, fever, diarrhea, dysentery. The plant has been evaluated for various pharmacological activities such as anti-inflammatory, anthelmintic, antibacterial, antifertility activity. Present review discusses phytochemistry and pharmacological aspects of the drug.
References
Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: CSIR; 1956. p. 261.
Kirtikar KR, Basu BD. Indian Medicinal Plants, BSMP Publishers, Dehradun, India; 1975. vol. I, p: 592.
CAZRI. Bordi-Ziziphus nummularia, A Shrub of Indian Arid Zone. (Eds. H.S. Mann & S.K. Saxena). CAZRI Monograph. 1981. p. 13.
Anonymous, The Wealth of India (Raw material) Vol XI: X-Z. Council of Industrial and Scientific Research, New Delhi; 1989. p. 111-124.
Nadkarni KM. Indian Materia Medica, Popular Prakashan, Bombay; 1986. p. 1315-1319.
Shah AH, Khan RMA, Maurya SK, Singh VP. Nummularine-S: A cyclopeptide alkaloid from the stem bark of Zizyphus nummularia. Phytochem. 1989; 28(1): 305-307.
Oudhia P, Research note on medicinal herb of Chhattisgarh, India having less known traditional uses, IX. Boir (Ziziphus nummularia, family: Rhamnaceae); 2003.
Warris HM, Wang H, Ahmad S, Alam K. Taxonomic studies of trees of the cholistan desert, Pakistan. J Biodiv Environ Sci. 2015; 6(1): 1-8.
Pandey A, Singh R, Radhamani J, Bhandari DC. Exploring the potential of Ziziphus nummularia (Burm. f.) From drier regions of India. Genetic Resources Crop Evolution. 2010; 57(6): 929-936.
Tschesche R. Kauffmann. The Alkaloids Chemistry & Physiology, Monske, RHF edition, Academic Press, London; 1975. Vol. 15, p: 165.
Singh B, Pandey VB. An N-formyl cyclopeptide alkaloid from Zizyphus nummularia Bark. Phytochem. 1995; 38 (1): 271-273.
Dwivedi SPD, Pandey VB. Cyclopeptide alkaloid from of Zizyphus nummularia. J. Nat. Prod. 1987; 50 (2): 235-237.
Devi S, Pandey VB, Singh JP, Shah AH. Peptide alkaloids from Zizyphus species. Phytochem. 1987; 12 (12): 3374-3375.
Pandey VB, Dwivedi SPD, Shah AH, Eckhardt G. Nummularine-O, A cyclopeptide alkaloid from Zizyphus nummularia. Phytochem. 1986; 25 (11): 2690-2691.
Pandey VB, Singh JP, Seth KK, Shah AH, Eckhardt G. Cyclopeptide alkaloids from of Zizyphus nummularia. Phytochem. 1984; 23 (9): 2118-2120.
Sharma SC, Kumar R. Chemical examination of Zizyphus nummularia. Pharmazie. 1983; 38 H. 1: 83.
Miana GA, Shah AH. Isolation of Jubanine-A, B and Mauritine-C from the root bark of Zizyphus nummularia. Fitoterapia. 1985; 117(6): 363-364.
Tschesche R, Elgamal M, Eckhardt G. Alkaloids from Rhamnaceae, XXVIII. Nummularin-G, -H and -K, further peptide alkaloids from Ziziphus nummularia Chem. Ber. 1977; 110 (7): 2649-2655.
Tschesche R, Elgamal M, Miana GA, Eckhardt G. Alkaloids from Rhamnaceae-XXVI: Nummularine-D, E and F, New cyclopeptide alkaloid from Zizyphus nummularia. Tetrahedron. 1975; 31: 2944-2947.
Tschesche R, Miana GA, Eckhardt G. Alkaloids from Rhamnaceae, XXV. Nummularin-A, -B and -C, three new 13-membered peptide alkaloids from Zizyphus nummulaira. Chem. Ber. 1974; 107 (10): 3180-3185.
Sharma SC, Kumar R. Zizynummin, A Dammarane Saponin from Zizyphus nummularia. Phytochem. 1983; 22(6): 1469-1471.
Srivastava SK. Nummularogenin, A new Spirostane from Zizyphus nummularia. J. Nat. Prod. 1984; 47(5): 781-783.
Srivastava SK, Chauhan JS. Chemical examination of whole plant of Zizyphus nummularia. Planta Medica. 1977; 32: 384-387.
Bachaya HA, Iqbal Z, Khan MN, Sindhu Z, Jabbar A. Anthelminthic activity of Zizyphus nummularia (bark) and Acacia nilotica (fruit) against Trichostrongylid nematodes of sheep. J. Ethanopharm. 2009; 123: 325-329.
Ray SD, Ray S, Zia-Ul-Haq M, Feo VD, Dewanjee S. Pharmacological basis of the use of the root bark of Zizyphus nummularia Aubrev. BMC Comp and Alter Med. 2015; 15: 416.
Goyal M, Sasmal D, Nagori BP. Analgesic and Anti-inflammatory activity of ethanolic extract of Zizyphus nummularia. Res. J. Med. Plants, 2012; 6(7): 521-528.
Goyal M, Ghosh M, Nagori BP, Sasmal D. Analgesic and anti-inflammatory studies of cyclopeptide alkaloid fraction of leaves of Ziziyphus nummularia. Saudi J. Bio. Sci. 2013; 20: 365-371.
Hasan Soliman Yusufoflu. Topical anti-inflammatory and wound healing activities of herbal gel of Zizyphus nummularia L. (F. Rhamnaceae) leaf extract. Int J Pharmacology, 2011; 7(8): 862-867.
Gautam S, Jain AK, Kumar A. Potential antimicrobial activity of Zizyphus nummularia against medically important pathogenic microorganisms. Asian J Trad Med. 2011; 6 (6): 267-271.
Pandey VB, Devi S. Biologically active cyclopeptide alkaloids from Rhamnaceae Plants. Planta Medica. 1990; 56: 649-650.
Rauf A, Ali J, Khan H, Mubarak S, Patel S. Emerging CAM Ziziphus nummularia with in vivo sedative-hypnotic, antipyretic and analgesic attributes. 3 Biotech. 2016; 6(1): 11.
Rajasekaran S, Jaykar B, Anandan R, Aboobacker sidheeq KP, Vannamalar S. Anti-diabetic activity of leaves of Zizyphus nummularia by Dexamethasone induced diabetic rat model. Int J Pharm Tech Res. 2013; 5(2): 844-851.
Rajasekaran S, Velmurugan C, Vetriselvan S, Rusliza B, Muthuramu T. Phytochemical and Pharmacological evaluation of leaves of Zizyphus nummularia (Burm.f.) Wight & Arn. Int J Phytopharm, 2012; 3 (3): 299-303.
Gupta D, Mann S, Jain I, Gupta RK. Phytochemical, Nutritional and Antioxidant Activity evaluation of fruits of Ziziphus nummularia Burm. F. Int J Pharm Bio Sci. 2011; 2(4): 629-638.
Kumar A, Sharma S, Kaushik C, Dhobal MP, Joshi BC. Antitumour Activity of Lapachol Isolated From Zizyphus Nummularia As Adjuvant For Radiation Therapy, Traditional Medicine & Materia Medica Research Center (TMRC) 2002: 1.
Shah GM, Khan MA, Ahmad M, Zafar M, Khan AA. Observations on antifertility and abortifacient herbal Drugs. African J Biotech. 2009; 8 (9):1959-1964.
Shah S, Din S, Rehmanullah, Jamal Q. Pharmacological evaluation of Ziziphus nummularia leaves for phytotoxic and molluscicidal bioassays. African J Pharmacy and Pharmacology, 2013; 7 (45) : 2887-2891.
