Pharmacological Evaluation and Antifertility Activity of Aloe barbadensis Linn on female wistar rats.
Keywords:Herbal Contraceptive, Antifertility, Reproductive outcome, Anti-implantation, Abortifacient, Estrogenic and Anti-estrogenic
Ethanolic and Aqueous extract of Leaf of Aloe barbadensiswas study, antifertility activity in proven fertile female Wistar Rats at the doses 500mg/kg b.wt./day for 30 days. Different parameters were studied in female wistar rats including effect of Reproductive outcome, Anti-implantation, Abortifacient study and Estrogenic and Anti-estrogenic activity, Phytochemical were observed.,Aloe vera Leaves shown positive test for Alkaloids, Steroid, Flavonoids, Terpene, Carbohydrates and Tannin. The extract of Aloe vera has anti-fertility effect the control rats showed good number of litters. Treatment of animal with different extracts, resulted a significant (P< 0.05, P< 0.01). antifertility activity (42.2% and 7.8%) was exhibited by AAV and WAV respectively. After 21 days of the extracts free period, the antifertility effect of the extracts was reversed. The extract treatments with AAV, an increase in the resorption index (%) by the extract is an indication of failure in the development of the embryo. The mean percentage of anti-implantation and percent resorption (abortifacient) were found to be highest for AAV-29.46%, WAV -12.17, and AAV-32.96%, WAV-7.78% respectively. The decrement in implantation caused by the extracts may be due to estrogenic or anti-estrogenic activity. However, along with standard AAVexhibiting more potent estrogenic and less potent anti-estrogenic when compared with standard.Clinical assessment of Female antifertility agents should include acceptability, safety and efficacy during and after the treatment. The present study was therefore carried out to evaluate the claimed antifertility effect of Aloe veraleaf using different aspects of reproductive physiology in female wistar rats.
lcoholic extract in female rat. Iranian Journal of Reproductive Medicine 2007;5:13-16.
Mishra N., Joshi S., Tondon VL.,Munjal A., Evaluation of Antifertility potential of aqueous extract of Bougainvillea spectabilis leaves in Swiss albino mice. Int J Pharm Sci Drug Res 2009;1:19-23.
Anonymous,Council of Scientific and Industrial Research. Wealth of India: Raw materials. New Delhi -India, 1956: 4:254-278.
Anonymous,The Wealth of India, Volume-(F-G). In: A Dictionary of Indian Raw Materials and industrial products. New Delhi: Council of Scientific and Industrial Research, 1999;4:246.
Gupta S.. Sampling and test of significance. In: Gupta, S. (Ed.), Statistical Methods. Sultan Chand and Sons Publishers, New Delhi, 1978:58–76.
Chopra RN., Chopra IC. and Varma BS., Supplement to Glossary of Indian Medicinal plants, reprinted edition,CSIR, NewDelhi, 1992:29.
Anonymous, the wealth of India, raw material s, council of scientific and in dustrial research, New Delhi, 4 (1952) 35-36.
Anonymous, pharmacopoeia of manager of publication, ministry of health, Government of India, Delhi, 2(1966) 947-948.
Fransworth NR., Biological and phytochemical screening of plants. Journal of Pharmaceutical Sciences 55(1966) 225-276.
Harborne J.B., Phytochemical Methods. A Guide to Modern Techniques of Plant Analysis, seconded. Chapmann and Hall, London (1984) 192.
Warrier PK., Indian medicinal plants, A compendium of 500 species by, Orient long man Ltd, Chennai,1996;3:34-35.
KokateCK. Practical pharmacognosy. New Delhi: Vallabh Prakashan,1999, 107-108.
Council of Scientific and Industrial Research. Wealth of India: Raw materials. New Delhi (India) 1956:4.
The Wealth of India, Volume-(F-G). In: A Dictionary of Indian Raw Materials and industrial products. New Delhi: Council of Scientific and Industrial Research,4 1999; 4: 246.
WassarmanPM.,Albertini D.F., The mammalian ovum. Im Knobil E, Neeill JD, Editors. The Physiology of reproduction, 2dned. Misgan: Raven Press, 1994: 79-122.
SalhadA.S. , IssaA.A., Alhougog I., "On the contraceptive effect of castor beans," Indian J Nat Med, 1997; 35: 63-5.
Endalk G., EyasM., AsfawD., Legesse Z. Phytochemical Screening and Pharmacological Evaluations for the Antifertility Effect of the Methanolic Root Extract of Rumex Steudelii," Journal of Ethanopharmacology. 2005; 96:139-143.
Hodgen AD.,Itskovits J.. The Physiology of Reproduction. Migan:Raven Press 1988:254.
Vasudeva N, Sharma SK. Post-coital antifertility activity of Achyranthes aspera Linn. root. J Ethnopharmacol 2006; 107:179-181.
Chauhan A., Agarwal M.,KushwahaS., A. Mutreja. Antifertility studies of Aegle marmelos Corr., an Indian medicinal plant on male albino rats. Egyptian Journal of Biology 2008;10:28-35.
Bhowmik D., Umadevi M., Kumar PKS, Duraivel S., Medicinal Plants with Potential Antifertility Activity. Journal of Medicinal Plants Studies, 2013;1:26-33.
HadleyMA.,. Lin YC , Dym M, Effect of gossypol on reproductive system of male rats. Journal of Andrology ,1981;2:190-199.
Soni D.,Gupta A., Solanki R.,JanaGK., Anti-implantation and pregnancy interruption activity of japakusuma (Hibiscus rosa-sinensis) in albino rats, International Journal Research in Ayurveda and Pharmacy, 2013;4:493-514.
Adhikary P., Banerji J., Choudhuri D., Das AK., Deb C.C., Mukherjee S.R. Chatterjee A, Antifertility effect of Piper betle Linn. extract on ovary and testes of Albino rats. Ind. J. Exp. Biol.,1989;27:868-70.
Kaur R., Sharma A., Kumar R., Kharb R.. Rising Trends towardsHerbal Contraceptives. J. Nat. Prod. Plant Resour, 2011;1( 4)5-12.
Ayogi PH., Rudresh K., Shrishailappa B., Saraswati BP., Somnath RP.Post-coital antifertility activity of Acalypha indica L. Journal of Ethnopharmacology 1999;67:253-258.
Koko II., Osinubi AA., Olabiyi OO., Kusemijiu TO., Noronha CC.,Okanlawon AO. Anti-ovulatory and anti-implantation potential of the methanolic extract of seeds of Abrus precatorius in the rat. Endocrine Practice2010;16:554-560.
Badami S, Aneesh R., Sankar S., Sathishkumar M.N., Suresh B., Rajan S.,Antifertility activity of Derris brevipes variety coriacea. Journal of Ethnopharmacology, 84 2003;84:99-104.