Antidiabetic potential of Lantana aculeata root extract in alloxan-induced diabetic rats
Keywords:
Antidiabetic activity, Lantana aculeata roots, Oleanolic acidAbstract
The present study investigates the antidiabetic potential of dried mature roots of Lantana aculeata, a weed belonging to verbenaceae family on biochemical profile in alloxan-induced diabetic rats. The effects of an ethanolic extract of the dried mature roots of Lantana aculeata on serum glucose, total cholesterol, triglycerides, plasma insulin and liver glycogen were examined in control and experimental groups. Lantana aculeata root extract reduced the serum glucose concentration at 24, 48 and 72 hours. To verify the activity sub-chronically, the extract administered orally in the doses of 25, 50 and 100 mg/kg to diabetic rats for 30 days, that significantly reduced the level of glucose, total cholesterol and triglycerides with an increase in insulin and glycogen concentration to near normal levels in a dose-dependent manner. The results indicate that roots of Lantana aculeata possess antidiabetic potential in alloxan-induced diabetic rats. The activity might be due to high concentration of oleanolic acid present in the roots.
References
Oudhia P, Dixit A. Weeds in Ambikapur
region (Madhya Pradesh) and their traditional
Use. Weed News 1994, 1: 19-21.
Holm LG, Pancho JV, Herberger JP,
Pluncknett DL, editors. A geographical atlas
of the world weeds. New York: John Wiley.;
The Wealth of India. Raw Materials, Vol. VI.
New Delhi, India: Council of Scientific and
Industrial Research.; 1989. p. 31-34.
Chhabra SC, Mahunnah RLA, Mshiu EN.
Plants used in traditional medicine in Eastern
Tanzania. J. Ethnopharm 1993, 39: 83-103.
Vinoth Kumar K: Studies on the toxicity and
biological significance of an indigenous weed
Lantana aculeata Linn. PhD thesis.
University of Madras, Department of
Zoology; 2008.
Scoppola A, Montecchi FR, Menzinger G,
Lala A. Urinary mevalonate excretion rate in
type 2 diabetic: role of metabolic control.
Atherosclerosis 2001, 156: 357-61.
Scheen AJ. From obesity to diabetes: why,
when and who?. Acta Clinica Belgica 2000,
: 9–15.
Seidell JC. Obesity, insulin resistance and
diabetes—A worldwide epidemic. British J.
Nutri 2000, 83 5–8.
Harborne JB. Phytochemical Methods.
London: Chapman and Hall.; 1973. p. 52-
Maillard M, Adewunmi CO, Hostettmann K.
A triterpene glycoside from the fruits of
Tetrapleura tetraptera. Phytochemistry 1992,
: 1321-23.
Umadevi S, Mohanta GP, Balakrishna K,
Manavalan R. Phytochemical investigation of
the leaves of Flaveria trinervia. Nat. Prod.
Sci 2005, 11: 13-15.
Misra LN, Dixit AK, Sharma RP. High
concentration of hepatoprotective oleanolic
acid and its derivatives in Lantana camara
roots. Planta Medica, 1997; 63:582.
Tinder P. Determination of blood glucose
using an oxidase peroxidase system with a
non-carcinogenic chromogen. Ann. Clini.
Biochem 1969, 6: 24-7.
Andersen L, Dinesen B, Jorgensen PN,
Poulsen F, Roder MF. Enzyme Immunoassay
for intact human insulin in serum or plasma.
Clini. Chem 1993, 38: 578–82.
Caroll WV, Longley RW, Roe JH. The
determination of glycogen in the liver and
muscle by the use of anthrone reagent. J. Biol.
Chem 1956, 220: 583– 593.
Allain CC, Poon LS, Chan CSG, Richmond
W, Fu PC. Enzymatic determination of total
serum cholesterol. J. Clini. Chem 1974, 20:
–75.
Jacobs NJ, Van Denmark P. Enzymatic
colour test for the quantitative determination
of triglyceride in human serum. Arch.
Biochem Biophy 1960, 88: 250-55.
Liu J, Hongbin S, Weigang D, Dongyan M,
Zhang L. Maslinic acid reduces blood glucose
in KK-Ay mice. Biol. Pharm. Bull 2007, 30:
-78.
Dawei G, Qingwang L, Ying L, Zhihua L,
Zhiwei L, Yusheng F, Zengsheng H, Jian L,
Kun L. Antidiabetic potential of oleanolic
acid from Ligustrum lucidum Ait. Canad. J.
Physio. Pharm 2007, 85: 1076-83.
Loci AS, Shaabha M, Khazraji AL, Husain A,
Twaija A. Hypoglycemic effect of a valuable
extract of artemicisia herb Alba II. Effect of a
valuable extract on some blood parameters in
diabetic animals. J. Ethanopharm 1994,
:167–71.9.
