Preliminary Phytochemical Screening and Anthelmintic Activity of Chloroxylon swietenia Root Extract

Authors

  • Ranjit Kumar Harwansh SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur- 495009 (C. G.), India.
  • Surendra Kumar Pareta SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur- 495009 (C. G.), India.
  • Kartik Chandra Patra LT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur- 495009 (C. G.), India
  • Md. Akhlaquer Rahman SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur- 495009 (C. G.), India

Keywords:

Anthelmintic, Chloroxylon swietenia, methanolic, chloroform, Pheretima posthuma

Abstract

The preliminary phytochemical investigation was carried out on the crude extracts of the roots of Chloroxylon swietenia. The crude extracts were investigated for their anthelmintic activity against Indian earthworms (Pheretima posthuma). Three concentrations (25, 50 and 100 mg/mL) of each extract were performed in activity, which involved the evaluation of paralysis and death period of the worm. Chloroform and methanol extracts exhibited significant anthelmintic activity at highest concentration of 100 mg/mL. Piperzine citrate was selected as standard compound and Di-methyl formamide as control. The anthelmintic activity of Chloroform and methanol of roots of Chloroxylon swietenia has therefore been evaluated for the first time.

References

Agbolade OM, Akinboye DO, and

AwolajamA: Intestinal helminthiasis and

Urinary schistosomiasis in some villages of

ljebu North, Ogun State, Nigeria. African

journal of Biotech 2004; 3:206-209.

Dornetshuber R, Kamyar MR, Rawnduzi P,

Baburin I, Kouri K, Pilz E, Hornbogen T,

Zocher R, Berger W and Gruber RL: Effect

of the anthelmintic drug PF1022A on

mammalian tissue and cells. Biochemical

Pharmacology 2009; 77:1437-1444.

Grover J K, Vats v, Uppal G, Yadav S:

Anthelmintic Activity. Trop Gastroenterol

; 22:180-9.

Allen H, Crompton DW T, Silwa ND,

loverde PT, and Old GR: New policy for

using anthelmintics in high risk

groups.Trends in parasitology 2002;

:381-382.

Deore SL, Khadabadi SS, Kamadi KS,

Ingle VP, Kawlkar NG, Sawarkar PS, Patil

VA, Vyas AJ: In vitro anthelmintic activity

of cassia tora. Int. J. Of Chem. Tech.

Rsearch 2009; 1:177-179.

Rastogi T, Bhutdav V, moon K, Aswar PB

and Khadabadi SS: Comperative studies on

anthelmintic activity of moringa olifera and

vitex negunda. Asian J. Research Chem

; 2:2.

Kamboj VP: Herbal Medicine. Current

Science 2000; 78:1.

Ravi Kiran, S. Sita Devi, P. “Evaluation of

mosquitocidal activity of essential oil &

sesquiterpenes from leaves of Chloroxylon

swieteria DC.” Parasitol Res 2004; 101:

-418.

Kiritikar KR and Basu BD. Ind. Medicinal

Plants, Ed 2nd, Vol. III, International book

distributor, Deharadun, India, 2001: 231

Ravi Kiran, S. Sita Devi, P. & Janardhan

Reddy, K. “Bioactivity of essential oils &

sesquiterpenes of Chloroxylon swieteria

DC, against Helicoverpa armigera” current

science. 2007; 93: 4, 23.

Ravi Kiran, S. Sita Devi, E P. Janardhan

Reddy,E K .Evaluation of in vitro

antimicrobial activity of leaf and stem

essential oils of Chloroxylon swietenia DC

World J Microbiol Biotechnol 2008;

:1909–1914.

Ravi kiran S. ; Shiva reddy A. ; Sita devi P.;

Janardhan reddy K. ; Insecticidal,

antifeedant and oviposition deterrent effects

of the essential oil and individual

compounds from leaves of Chloroxylon

swietenia DC . Pest management science.

:62- 1116-1121.

Sharma AK, Chandan BK, Anand KK and

Pushpangadan P. Antifertility activity of

Chloroxylon swietenia DC. In Rats.

Zoologica Orietalis. 1989; 4(2): 50-55.

Senthil raja A. ; Ramkumar R. Analgesic

activity of chloroxylon swietenia. Indian

drugs 2003; 40,: 134-36 .

Vorkoc J ., sedmera, p., Evaluation of antiinflammatory activity and toxicity related

studies of chloroxylon sweitenia

Phytochem, 1977; 11:2647.

Kokate CK, Purohit AP, Gokhale SB.

Practical Pharmacognocy, Ed 30, Nirali

Prakashan, Pune, 2004: 593-597

Pratt RT, Chess ER. Fluorescence of

powdered vegetable drugs in particular to

develop system of identification. J Am

Pharm Ass. 1949; 38:324-331

Kakoski CJ, Kakoski RJ, Sharma M.

Fluorescence of powdered vegetable drugs

under ultraviolet radiations. J Am Pharm

Ass. 1958 ;47:715-717

Dutta AC, Dutta TC. Botany, Ed 6th. Oxford

University Press, 1995: 556

Ajaiyeoba EO, Onocha PA, Olarenwaju

OT: In vitro anthelmintic properties of

Buchholzia coriaceae and Gynandropsis

gynandra extract. Pharm Biol 2001; 39:217-

Mali GR, Hundiwale CJ, Sonawane SR,

Patil NR, Hatapakki CB: Evaluation of

Capparis decidua for anthelmintic and

antimicrobial activities. Ind J Nat Prod

; 20:10-3.

Kane RS, Mohite KS, Shete SJ:

Antihelmintic activity of aqueous and

methanolic extracts of euphorbia thymifolia

linn. Int J Pharm Tech Res 2009; 1:666-9.

Martin RJ: c-Aminobutyric acid and

piperazine activated single channel current

from Ascaris suum body muscle. Br J

Pharmacol 1985; 84:445–61.

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Published

30-09-2010

How to Cite

1.
Ranjit Kumar Harwansh, Surendra Kumar Pareta, Kartik Chandra Patra, Md. Akhlaquer Rahman. Preliminary Phytochemical Screening and Anthelmintic Activity of Chloroxylon swietenia Root Extract. ijp [Internet]. 2010 Sep. 30 [cited 2024 Sep. 28];2(3):255-9. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/44

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