Anthelmintic activity of Ethanolic extract of whole plant of Eupatorium Odoratum. L


  • Jitendra Patel Department of Pharmacognosy, Bharat Institute of Technology-School of Pharmacy, Mangalpally, Ibrahimpatnam, RR Dist- 501510, AP, India.
  • G.S. Kumar Department of Pharmacognosy, Bharat Institute of Technology-School of Pharmacy, Mangalpally, Ibrahimpatnam, RR Dist- 501510, AP, India.
  • Md. Shamim Quresh Department of Pharmacognosy, 3Department of Pharmaceutical Chemistry, Jeypore College of Pharmacy Rondapalli, (K) Orissa- 764002 India
  • P.K. Jena Department of Pharmacognosy, Bharat Institute of Technology-School of Pharmacy, Mangalpally, Ibrahimpatnam, RR Dist- 501510, AP, India.


Anthelmintic activity, Eupatorium Odoratum, Pheretima posithuma, Piperazine citrat


Successive extracts from the Whole plant of Eupatorium Odoratum. L (Asteraceae) were investigated for their anthelmintic activity against Pheretima posthuma and three concentrations (10, 50 and 100 mg/ml) of each extracts were studied in activity, which involved the determination of time of paralysis and time of death of the worm. Ethanolic extract exhibited significant anthelmintic activity at highest concentration of 100 mg/ml. Piperazine citrate in 10 mg/ml concentration as that of extract was included as standard reference and 1% Gum acacia in normal saline as control. The anthelmintic activity of ethanloic extract was significant followed by hydroalcoholic extract of Eupatorium Odoratum.

Author Biography

Jitendra Patel, Department of Pharmacognosy, Bharat Institute of Technology-School of Pharmacy, Mangalpally, Ibrahimpatnam, RR Dist- 501510, AP, India.



Bundy DA: Immunoepidemiology of

intestinal helmintihc infection, The global

burden of intestinal nematode disease.

Trans. Royal. Soc. Trop. Med. Hyg.


Coles GC:. Anthelmintic resistance and the

control of worms. J Med. Microb


Geerts S, Gryseels B: Drug resistance in

human helminths: current situation and

lessons from the livestock. Clin. Microbiol.


Sangster NC: Anthelmintic resistance: past,

present and future. Intl. J.


Padilha T: Resíduos de Anti-helmínticos na

Carne e Leite. In: Controle dos

Nematóides Gastrintestinais em

Ruminantes. Padilha, T., Ed., General

Pacheco, Embrapa-CNPGL.1996,258.

Turnipseed SB, Roybal JE, Rupp HS,

Gonzalez SA, Pfenning AP, Hurlbut JA:

Confirmation of avermectin residues in

food matrices with negative-ion

atmospheric pressure chemical ionization

liquid chromatography / mass spectrometry.

Rapid. Comm. Mass. Spec.1999,13:493-

Hamond JA, Fielding D, Bishop SC:

Prospects for plant anthelmintics in tropical

veterinary medicine. Vet. Res.


Schmidt GJ, Schilling EE: Phylogeny and

Biogeography of Eupatorium (Asteraceae:

Eupatorieae) Based on Nuclear ITS

Sequence. Amer. J. Bot.2000, 87(5):716-

Sasaki Yohei, Matsumoto Atsushi, Takido

Michio, Yoshimura Mamoru, Nagumo

Seiji: "Study on Eupatorium Plants Called

"Fujibakama". Jap. J.


Rejitha Gopinath:

Diuretic activity of Eupatorium odoratum L

inn. J. Pharm. Res, 2009;2(5): 844-846.

Victor B Owoyele, Joseph O Adedij,

Ayodele O Soladoy: Anti-inflammatory

activity of aqueous leaf extract

of Chromolaena odorata.

Inflammopharmacology. 2005,13(5-


Biswal PR, Sardar KK, Parija SC, Mishra

PR, Mishra SN: Wound healing effect of

eupatorium odoratum linn, and himax in

rabbits. Indi. J. of Indige. Medi..


Lakshman Lal: Studies on natural

repellents against potato tuber moth

(Phthorimaea operculella Zeller) in country

stores. Potato Research. 1987,30( 2): 329-

Apichart Suksamrarn, Apinya Chotipong,

Tananit Suavansri, Somnuk Boongird,

Puntip Timsuksai, aovaluk Vimuttipong and

Aporn Chuaynugul: Antimycobacterial

activity and cytotoxicity of flavonoids from

the flowers of Chromolaena odorata. Arch.

of Pharmaco. Res.2004,27(5):507-511.

Prasad S, Narayana K, Jayakumar K:

Phytochemical analysis of toxic plant

Chromolaena odorata (Eupatorium

odoratum). J. of Indi. Soci. of Toxic.


Kumar GS, Jayaveera KN, Kumar CK

Ashok, Umachigi P Sanjay,Vrushabendra

Swamy BM, Kumar DV Kishore:

Antimicrobial effects of Indian medicinal

plants against acne-inducing bacteria. Tropi.

J. of Ph. Res. June .2007,6 (2):717-723.

Vidyarthi RD: A Textbook of Zoology.

th ed. New Delhi: Chand and Co.


Thorn GW, Adams RD, Brunwald E,

Isselbacher KJ, Petersdorf RG: Harrison’s

Principles of Internal Medicine. New York;

Mc Grew Hill.1977,1088-90.

Vigar Z: Atlas of Medical Parasitology. 2nd

ed. Singapore:Publishing House;


Ghosh T, Maity Tk, Bose A and Dash GK:

Anthelmintic activity of Bacopa monierri,

Indi. J.Nat Pro.2005,21:16-19.

Mathew AS, Patel KN, Shah BK: Indi. J.

Nat.Prod.1995,14 (1):11.

Vagdevi HM, Latha KP, Vaidya VP,

Vijayakumar M, Pai KS: Synthesis and

Pharmacological screening of some novel

naphtha (2, 1-b) Furo-pyrazolines,

isoxazoles and isoxazolines, Indi. J. harma.

Sci.2001, 63: 286-291.

Bolton S: In Pharmaceutical StatisticsPractical and Clinical Applications. New

York: Marcel Dekker. 1997,69-78.

Bate-Smith EC: The phenolic constituents

of plants and their taxonomic

significance 1. Dicotyledons. J. Linn. Soc.

Bot. 1962,58:95-173.

Martin RJ: Mode of action of Anthelmintic

drugs. Vet. J.1997, 154:11-34.

Gamenara DE, Pandolfi, Saldana J,

Dominguez L, Martinez MM, Seoane G:

Nematocidal activity of natural polyphenols

from bryophytes and their derivatives.


Athnasiadou S, Kyriazakis I, Jackson F,

Coop RL: Direct anthelmintic effects of

condensed tannins towards different

gastrointestinal nematodes of sheep: In vitro

and in vivo studies. Vet.


Thompson DP, Geary TG: The structure

and function of helminth surfaces. In:

Biochemistry and Molecular Biology of

Parasites (J. J. Marr, Ed.), 1st ed. Academic

Press, New York.1995,203-232.

Coop RL, Holmes PH: Nutrition and

parasite interaction. Int. J. Parasitol.


Van houtert MFJ, Sykes AR: Implications

of nutrition for the ability of ruminants to

withstand gastrointestinal nematode

infections. Int. J. Parasitol. 1996,26:1151-

Donaldson J, Van houtert MFJ, Sykes AR:

The effect of protein supply on the

peripaturient parasite status of the mature

ewe. Proc. New Zealand Soc. An.


Waller PJ, Bernes G, Thomsborg SM,

Sukur A, Richter SH, Ingebrigtsen K,

Hoglund J: Plants as de-worming agents of

livestock in Nordic countries: historical

perspective,popular beliefs and prospects

for the future. Acta Vet.Scand.2001,42:31-

Wang Y, Waghorn GC, Douglas GB, Barry

TN, Wilson GF: The effect of condensed

tannins in Lotus corniculatus upon nutrient

metabolism and upon body and wool

growth in grazing sheep. Proc. New

Zealand Soc. of An. Prod. 1994,54:219-


Pessoa LM, Morais SM, Bevilaqua CM,

Luciano JH: Anthelmintic activity of

Essential oil of Ocimum gratissimum Linn.

and eugenol against Haemonchus

contortus. Vet. Parasitol.2002,109:59-63.

Lahlou M: Potential of Origanum

compactum as a cercaricide in Morocco.

Ann. Trop. Med. Parasitol.2002,96:587-




How to Cite

Jitendra Patel, G.S. Kumar, Md. Shamim Quresh, P.K. Jena. Anthelmintic activity of Ethanolic extract of whole plant of Eupatorium Odoratum. L. ijp [Internet]. 2010 Jun. 30 [cited 2024 Jun. 21];2(2):127-32. Available from:



Original Research Articles