Antioxidative and antiproliferative activities of isolated compounds from Prunus domestica: an in vitro study

Authors

  • Naveen Dhingra School of Life Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore-452001 India.
  • Rajesh Sharma School of Pharmacy, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore-452001 India.
  • Anand Kar School of Life Sciences, Devi Ahilya University, Takshashila Campus, Khandwa Road, Indore-452001 India.

Keywords:

Prunus domestica, antioxidant, antiproliferative, DPPH, human breast cancer cell lines

Abstract

In this investigation the antioxidant as well as antiproliferative activities of different isolated compounds from ethyl acetate fraction of Prunus domestica (peel + flesh) were studied in two human breast cancer cell lines, MCF-7 and MDA-MB-468. Free radical scavengering as done with 2, 2-diphenyl-1-picrylhydrazyl (DPPH) study indicated different degrees of antioxidative activity of the isolated compounds such as chlorogenic acid, protocatechuic acid, vanillic acid, ferulic acid, p-coumaric acid and rutin. However maximum antioxidative activity was observed in chlorogenic acid with IC50 of 0.115 mg/ml. With respect to antiproliferative potential, chlorogenic acid also exhibited the maximum antiproliferative activity on MCF-7 and protocatechuic acid on MDA-MB-468 human breast cancer cell lines. This appears to be the first report that provides a comparative account on the antioxidant and antiproliferative property of some isolated active compounds of the Indian variety of fruit, Prunus domestica.

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Published

30-09-2013

How to Cite

1.
Naveen Dhingra, Rajesh Sharma, Anand Kar. Antioxidative and antiproliferative activities of isolated compounds from Prunus domestica: an in vitro study. ijp [Internet]. 2013 Sep. 30 [cited 2024 Oct. 8];5(3):341-6. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/270

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Original Research Articles