The Botany, Chemistry, Pharmacological and Therapeutic Application of Psoralea corylifolia L. – A Review
Keywords:
Psoralen, Isopsoralen, Pharmacological activities, Psoralea corylifolia Linn.Abstract
Psoralea corylifolia Linn. is an endangered and medicinally important plant indigenous to tropical and subtropical regions of the world. Its medicinal usage is reported in Indian pharmaceutical codex, the Chinese, British and the American pharmacopoeias and in different traditional system of medicines such as Ayurveda, Unani and Siddha. The review reveals that wide ranges of phytochemical constituents have been isolated from the plant and it possesses important activities like antibacterial, antiinflammatory and antitumer. Various other activities like hepatoprotective, antioxidants and antithelminitic have also been reported. These repots are very encouraging and indicate that herb should be studied more expensively for its therapeutic benefits. This article briefly reviews the botany, pharmacology, biochemistry and therapeutic application of the plant. This is an attempt to compile and document information on different aspects of Psoralea corylifolia and highlight the need for research and development.
References
WHO, IUCN and WWF, Guidance on the
conservation of medicinal plant (IUCN
Gland Switzerland), 1993.
Kotnis MS, Patel P, Menon SN, Sane RT,
Reneprotective effect of Hemisdesmus
indicus a herbal drug used in gentomicininduced renal toxicity. Nephrology
(Carlton). 2004;3:142-152.
Uniyal B, Utilization of medicinal plants
by the rural women of kulu, Himachal
Pradesh. Indian J. of Traditional
Knowledge. 2003; 2(4): 366 –370.
Dahaukar SA, Kulkarni AR, Rege NN,
Pharmacology of medicinal plants and
natural products, Indian J. of
Pharmacology.2000;32:81-118.
Harsha VH, Hebbar SS, Hegde GR,
Shripatti V, Ethanomedical knowledge of
plants used by Kunabi tribs of Karnataka
in India,Fitoterapia.2002;73(4):281 –287.
Ashis G, Herbal folk remedies of Bankura
and Medinipur district, West Bengal.
Indial J. of Traditional Knowledge, 2003;
(4): 393-396.
Bhattacharjee SK. (ed.), in Hand Book of
Medicinal Plants,Pointer Publishers,
Jaipur. 1998; 287 –288.
In The Wealth of India: A Dictionary of
Indian Raw Materials andIndustrial
Products, Raw Materials, Publication and
Information Directorate, CSIR, New
Delhi, 1989; 8:296–297.
Sahrawat AK, Chand S. Continuous
sometic embryogenesis and plant
regeneration from hypocotyle segment of
Psoralea corylifolia L. an endangered and
medicinally important plant.Curr.sci.
; 81:10 -25.
Sharma PV. Hand book of Ayurveda
(dravyagun) 2005;2 :175 -178.
Hyo JA, Seo JM, Choi Y, Park RK, Jeong
S, Lee JY, Kim HM, Um JY, Hong SH.,
Induction of nitric oxide and tumor
necrosis factor - ∝ by Psoralea corylifolia
,Indian J. Med. Res. 2008;128:752-758.
Liu R, Aifeng LI, Sun A, Kong L.
Preprative isolation and purification from
Psoralea corylifolia by high speed
counter current chromatography.J. of
chro.2004;1057:225 -228.
Oudhiya P. Traditional medicinal
knowledge about herb Bemchi(Psoralea
corylifolia) in chhatisgarh, India.
Pharmacy. 2001; 61(7): 312-332.
Chand S, Sahrawat AK. Sometic
emriogenesis and plant regeneration from
root segment of Psoralea corylifolia L.
An endangered medicinal plant., In vitro.
Cell. Dev. Biol. 2002; 33-38.
Jeyakumar M, Jayabalan N., In vitro plant
regeneration from cotyledonary node of
Psoralea corylifolia L. Plant Tissue
cult.2002; 12(2): 125-129.
Yin S, Fan CQ, Wang Y, Dong L, Yue
JM., Antibacterialprenylflavone
derivatives from Psoralea corylifolia, and
theirstructure-activity relationship study.
Bioorg Med Chem. 2004.
Rajput SJ, Vijaya Z, Pallavi R., Studies
on extraction ,isolation and estimation of
Psoralea corylifolia, Pharmaco.Magazine,
;4 :13 Jan-Mar.
Shinde AN, Malpathak N, Fulzele DP.,
Induced high frequency shoot
regeneration and inhanced isoflevonces
productin in Psoralia
corylifolia.Rec.Nat.Prod. 2009; 3:38-45.
Zhao LH, Wu MH, Xiang BR., Analysis
of Psoralea corylifoliaL. fruits in
different regions. Chem Pharm Bull
(Tokyo). 2005.
Xu J. Chinese Journal of Disinfection,
; 13: 92—96.
Jeyakumar M, Jayabalan N., An efficient
method for regeneration of plantletsfrom
nodal explants of Psoralea corylifolia L.
Plant. Cell Biotech. Mol. Biol.2000;
(1&2): 37.
Sun NJ, Woo SH, Cassady JM, Snapka
RM., DNA polymerase and
topoisomerase II inhibitorsfrom Psoralea
corylifolia. J. Nat. Prod.1998; 61: 362-
Xiong Z, Wang D, Xu Y, Li F.,
Osteoblastic differentiation bioassay and
its application to investigating the activity
of fractions and compounds from
Psoralea corylifolia L.,Electronic J.
;58:925-928.
Sheng Y, Fan CQ, Wang Y, Dong L, Yue
JM. antivacterial prenylflavone
derivatives from Psoralea corylifolia and
their structure. Activity relationship study.
Biooranii is medicinal chemistry 2004;
: 4387-4392.
Jiangning G, Xinchu W, Hou W,
Qinghua L, Kaishun B. Antioxidants from
a Chinese medicinal herb-Psoralia
corylifoliaL. Phyto-therapy research 2004;
: 539-544.
Prasad R, Anandi C, Balasubramanian S,
Pugalendi KV. Antidermatophytic activity
of extracts from Psoralea corylifolia
(fabaceae) correlated with the presence of
a flavonoid compound. Journal of
ethanopharmacology. 2004; 91: 21-24.
Ryu SV., Choi SU., Lee CO. and Zee
OP., Antitumor activity of psoralea
corylifolia. Archives of pharmacal
research 2008; 15: 356-359.
Khatune NA, Islam ME., Rahman MAA.
Baki MA., Gadik G. Haque ME.,
Pesticidal activity of a novel coumestan
derivative isolated from psoralea
corylifolia L. Against Tribolium
casteneum Herbst. Adults and Larvae
(coleptera : Tenebrionidae) Pakistan
journal of agronomy. 2002;(4): 112-115.
Forestieri A M., Monfortre MT., Ragusa
S. Trovato A, Lauk L., Antiinflammatory
Analgesic and antipyretic activity in
rodents of plant extract used in African
medicine, phytother Res, 1996; 10 (2):
-103.
Shilaskar DV, Parasar GC., Studies on
effect of psoralea corylifolia nd piper
bettle on cholinesterase and succinil
dehydrogenase. Enzymes as possible
targets of their anthelmintic action. planta
med.2001; 62(7): 557-62.
Cho H, Jun JY, Song EK, Kang KH, Baek
HY, Kd YS, Kim YC., Bakuchiol : A
hepatoprotective compound of Psoralea
corylifolia on tacrine – induced
cytotoxicity in Hep G2 cells. Planta med
; 67: 784 -749.
Wand D, Famei H, Jiang Z., Osteoblastic
proliferation stimulatin activity of
Psoralea corylifolia extracts and two of
its flavonoids. International
immunopharmacology. 2001; 1: 1849 -
Sun NJ, Woo SH, Cassady JM, Snapka
RM., DNA polymerase and
Topoisomerase II inhibitors from
Psoralea corylifolia. J. Nat. prod., 1998;
(3): 362-366.
