Hepatoprotective activity of aqueous extract of Balanites aegyptiaca L. Delile (Balanitaceae) roots bark

Authors

  • TRAORE Tata Kadiatou 1 : Laboratoire de Développement du Médicament (LADME), Ecole Doctorale de la Santé, Université Joseph Ki-Zerbo, 03 BP 7021, Ouagadougou 03, Burkina Faso. 2 : Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
  • Noufou Ouédraogo Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso. Unité Mixte de Recherche Internationale – Environnement (UMI), Santé, Sociétés (UMI 3189, ESS), CNRST/CNRS/UCAD/UGB/USTTB, Burkina Faso.
  • Geoffroy G. Ouédraogo Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
  • Gilchrist A. L. Boly 1 : Laboratoire de Développement du Médicament (LADME), Ecole Doctorale de la Santé, Université Joseph Ki-Zerbo, 03 BP 7021, Ouagadougou 03, Burkina Faso. 2 : Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
  • Leïla M. E. W. Kabré Laboratoire de Développement du Médicament (LADME), Ecole Doctorale de la Santé, Université Joseph Ki-Zerbo, 03 BP 7021, Ouagadougou 03, Burkina Faso. Laboratoire de Biochimie et de Chimie Appliquée (LABIOCA), Université Joseph Ki-Zerbo, 03 BP 848 Ouagadougou 03, Burkina Faso
  • Ernest N Sombié Laboratoire de Biochimie et de Chimie Appliquée (LABIOCA), Université Joseph Ki-Zerbo, 03 BP 848 Ouagadougou 03, Burkina Faso
  • Jotham Y. N’Do Laboratoire de Biochimie et de Chimie Appliquée (LABIOCA), Université Joseph Ki-Zerbo, 03 BP 848 Ouagadougou 03, Burkina Faso
  • Salfo Ouédraogo Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
  • Marius Lompo Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
  • Sylvin Ouédraogo Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
  • André Tibiri Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso.
  • Innocent Pierre Guissou Département Médecine et Pharmacopée Traditionnelles – Pharmacie (MEPHATRA-PH), Institut de Recherche en Sciences de la Santé (IRSS/CNRST), 03 BP 7192 Ouagadougou 03, Burkina Faso. Faculté des sciences de la santé, Université Saint Thomas d’Aquin (USTA), 06 BP: 10212 Ouagadougou 06, Burkina Faso.

Keywords:

Balanites aegyptiaca, Aqueous extract, Acute toxicity, Hepatotoxicity, Carbon tetrachloride

Abstract

Balanites aegyptiaca (L.) Del (Balanitaceae) is traditionally used for the treatment of various ailments such as syphilis, jaundice and liver disorders, epilepsy, ... This study was designed to evaluate acute toxicity and hepatoprotective effect of aqueous extract of Balanites aegyptiaca on CCl4 induced hepatotoxicity in rats. Methods: Acute toxicity was assessed with the extract at a dose of 2000 mg / kg bw. The extract at doses of 25, 50 and 100 mg / kg b.w. was orally administered respectively to CC14-induced hepatotoxicity (0.5 ml / kg) animals. Silymarin (100 mg / kg) was given as a reference. Biochemical parameters such as ALT, AST, PT, ALB and ALP were assayed as well as enzymatic antioxidant activities SOD, CAT and MDA. Nitrogen monoxide (NO) involved in inflammation was also measured. Results: Activities of liver marker enzymes, ALT, AST and ALP, total protein, albumin and showed a significant hepatoprotective effect. Regarding antioxidant enzymatic activities in vivo (SOD, CAT and MDA) of aqueous extract exhibited a significant effect showing increasing levels of SOD, CAT and reducing malondialdehyde (MDA) levels. The production of NO is significantly reduced compared to the batch intoxicated by CCl4. Conclusion: Balanites aegyptiaca is endowed with hepatoprotective properties that can be attributed to antioxidant potential which could justify its use in traditional medicine in liver disorders.

References

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Published

30-09-2020

How to Cite

1.
TRAORE Tata Kadiatou, Noufou Ouédraogo, Geoffroy G. Ouédraogo, Gilchrist A. L. Boly, Leïla M. E. W. Kabré, Ernest N Sombié, Jotham Y. N’Do, Salfo Ouédraogo, Marius Lompo, Sylvin Ouédraogo, André Tibiri, Innocent Pierre Guissou. Hepatoprotective activity of aqueous extract of Balanites aegyptiaca L. Delile (Balanitaceae) roots bark. ijp [Internet]. 2020 Sep. 30 [cited 2024 Dec. 5];12(3):54-9. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/637

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