In- vivo diuretic and antiulcer activity in fruits of Buchanania lanzan
Keywords:
Antiulcer, diuretic activityAbstract
Ethnopharmacological relevance: The fruits of Buchanania lanzan are used traditionally in the treatment of skin afflictions, sores, ulcers, inflammation and as diuretic (1,21,35,42). The aim of the study was to investigate the antiulcer and diuretic activity of the crude ethanolic and pet. ether extract from the fruits of Buchanania lanzan. Materials and methods: The antiulcer activity of the crude extracts was evaluated in ethanol and pylorus ligation induced model for gastric lesions in Wister albino rats (2,8,12,19). Parameters such as gastric volume, pH and acidity were determined in the pylorus ligation model. Furthermore the diuretic activity was evaluated in comparison of Standard drug i.e. Furosemide. Results: The acute toxicity studies revealed that LD50> 2000mg/kg for the extract. The extract caused a significant (p<0.05) dose-dependent inhibition of ulcer in the ethanol and pylorus ligation induced ulcer models at the dose of 250mg/kg, respectively. And the diuretic activity of extract also found significant (p<0.01) dose dependent increase in urine volume. Both ethanol and aqueous extracts have showed a significant dose-dependent increase in the excretion of electrolytes when compared to the control group. Conclusion: Our data provide a rational base for the folkloric use of Buchanania lanzan in the treatment of ulcers and as diuretic.
References
Jain E, Basal A. Inhibition of Propionibacterium acnes-induced mediators of inflammation by Indian herbs. Phytomedicine. 2003;10:34–8.
Shirwaikar A, Prabhu KS, Punitha IS. In vitro antioxidant studies of Sphaeranthusindicus (Linn) Indian J Exp Biol. 2006;44:993–6.
Tiwari A, Saxena RC. Repellent and feeding deterant activity of Sphaeranthusindicus against Triboliumcastanum. Bio-research Bull. 2003;1:179–284.
Anon. Current European concepts in the management of Helicobacter pylori infection. The Maastricht Consensus Report. European Helicobacter pylori Study Group. Gut 1997;41:8–13
Chatterjee SC. Pakrashi.1st ed. Vol-5. New Delhi: National Institute of Science communication and information resources. The treatise on Indian medicinal plants. 2003;177.
Anon. NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in Peptic Ulcer Disease. JAMA 1994;272:65–69.
Antimicrobial activity of Medicinal plant Sphaeranthusindicus. International conference on modern trends in plant sciences with special reference to the role of biodiversity in conservation. 96.
Bafna AR, Mishra SH. Immunomodulatory activity of methanol extract of flower heads ofSphaeranthusindicus Linn. ArsPharmaceutica. 2004;45:281–91.
Marshall BK, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration, Lancet.1984;1:1311–15.
Nanda BK, Jena J, Rath B, Behera BR. Analgesic and Antipyretic activity of whole parts of Sphaeranthus indicus Linn. J ChemPharma Res. 2009;1:207–12.
Tiwari BK, Khosa RL. Hepatoprotective and antioxidant effects of Sphaeranthusindicus against acetaminophen induced hepatotoxicity in rats. J PharmaSci Res. 2009;1:26–30.
Naqvi BS, Hashmi K, Sheikh D, Mahdi A. Antibacterial activity in fruits and vegetables. Pak J Pharmacol. 1998;15:7–11.
Shaikh D, Naqui BS, Shaikh R. The antimicrobial principles of Sphaeranthusindicus: Isolation, purification and antimicrobial action. Pak J Scientific Ind Res. 1986;29:366–71.
Sadaf F, Saleem R, Ahmed M, Ahmad SI. Navaid-ul-Zafar Healing potential of cream containing extract of Sphaeranthusindicus on dermal wounds in guinea pigs. J Ethnopharmacol. 2006;107:161–3.
Chan FK. Helicobacter pylori and non-steroidal anti-inflammatory drugs. GastroenterolClin North Am 2001;30:937–52
Singh G, Triadafilopoulus G; Epidemiology of NSAID-induced GI complications. J Rheumatol 1999;26(26):18–24.
Higham J, Kang JY, Majeed A. Recent trends in admissions and mortality due to peptic ulcer in England: increasing frequency of haemorrhage among older subjects. Gut. 2002;50:460–64.
Mathew JE, Srinivasan KK, Dinakaran V. A Joseph Mast cell stabilizing effects of Sphaeranthusindicus. J Ethnopharmacol. 2009;122:394–6.
Kurata JH. Epidemiology of peptic ulcer disease. ClinGastroenterol 1984;13:289.
Vijaya K, Anathan S. Microbiological screening of Indian Medicinal plants with special reference to enteropathogens. J Altern Comp Med. 1997;3:13–20.
Tripathi KD. Essential of Medical Pharmacology, Diuretics, Pub. Jaypee, 2009;218-25.
Kirtikar KR, Basu BD. Indian medicinal plants. In: Blatter E, Caius JF, Mhaskar KS, editors. 2nd ed. Vol-2. Allahabad India: Lalit Mohan Basu. 1981;1346–8.
Dubey KS, Ansari AH, Harduha M. Antimicrobial activity of the extract of Sphaeranthusindicus. Asian J Chem. 2000;12:577–8.
Prabhu KS, Lobo R, Shirwaikar A. Antidiabetic properties of the alcoholic extract of Sphaeranthusindicus in streptozotocin - nicotinamide diabetic rats. J Pharm Pharmacol. 2008;60:909–16.
Heinrich M, Robles M, West JE, Ortiz de Montellano BR, Rodriguez E . Ethnopharmacology of Mexican Asteraceae (Compositae) Annu Rev Pharmacol Toxicol. 1998;38:539–65.
Nisha M, Kalyanasundaram M, PailyAbidha KP, Vanamail P, Balaraman K. In vitro screening of medicinal plant extracts for macrofilaricidal activity. Parasitol Res. 2007;100:575–9.
Sharma M, Saxena RC. Sphaeranthusindicus as mosquito larvicide. J Appl Zool Res. 1996;7:87–8.
Ali MA, Mikage M, Kiuchi F, Tsuda Y, Kondo K. Screening of crude drugs used in Bangladesh for nematocidal activity on the larva of toxocaracanis. ShoyakugakuZasshi. 1991;45:206–14.
Marck Manuals, Home health handbook for patients & caregivers, Oct 2006.
Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN, Ray C. Screening of Indian plants for biological activity. Indian J Exp Biol. 1968;6:232–47.
Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs. N Engl J Med 1999;340: 1888–99.
Shekhani M S, Shah P M, Yasmin A, Siddiqui R, Perveen S, Mohammed K. et al. An immune stimulant sesquiterpene glycoside from Spharanthusindicus. Phytochemistry.1990;29:2573–6.
Mhetre NA, Ambavade SD, Bodhankar SL. Neuroleptic activity of extract of Sphaeranthusindicus in mice. Indian J Nat Prod. 2006; 22:24–7.
Nanba Y, Hatsutori K, Shimomura Nakamura Masami. (Mikimoto Seiyaku Kk; Nanba Tsuneo) Jpn. KokaiTokkyoKoho 1995; JP 07, 138, 180[95,138,180] ChemAbstr. 1995;123:92919r. as cited in J Ethnopharmacol 2006;107:161-3.
Sravani P, Lakshmi SM, Saravana AK. A review on natural diuretics ,International Journal of Pharmacy & Therapeutics. 2010;1(1):1-5.
Lalla PM, Deshpande AR, Musaddip M, Shahare NH, Ukesh CS. Maharashtra: Amravati. 2005.
Jha RK, Garud N, Nema RK . Excision and incision wound healing activity of flower head alcoholic extract of Sphaeranthusindicus Linn.in albino rats. Global J Pharmacol. 2009;3:32–7.
Sarpate RV, Deore TK, Tupkari SV. Bronchodilatory effect of Sphaeranthusindicus Linn against allergen induced bronchospasm in guinea pigs. Pharmacog Mag. 2009;5:74–7.
Vimalanathan S, Ignacimuthu S, Hudson JB. Medicinal plants of Tamil Nadu (Southern India) are a rich source of antiviral activities. Pharma Biol. 2009;47:422–9.
Garg SC, Kasera HL. Antifungal activity of the essential oil of Sphaeranthusindicus Linn. Pafai J.1982;4:23–4.
Garg SC, Kasera HL. In vitro antibacterial activity of the essential oil of Spharanthusindicus L. Fitoterapia. 1983;54:37–9.
Srivastav SC, Khan MS, Vohra SB. Pharmacological and haemostatic investigation onSphaeranthusindicus Linn. Indian J Physiol Pharmacol. 1971;15:27–33.
Ambavade SD, MhetreNA, Tate VD, Bodhankar SL. Pharmacological evaluation of the extracts of Sphaeranthusindicus flowers on anxiolytic activity in mice. Indian J Pharmacol. 2006;38:254–9.
Singh SK, Saroj KM, Tripathi VJ, Singh AK, Singh RH. An Antimicrobial Principle from Sphaeranthusindicus L. (Family Compositae) Int J Crude Drug Res. 1988;26:235–9.
Nayak SS, Maity TK, Maiti BC. Hepatoprotective activity of Sphaeranthusindicus Linn. Int J Green Pharm. 2007;1:32–6.
Hameed SVS, Shah DS. Effect of aqueous extracts of S. indicus against Calexfatigans, weid (Diptera; calicidae) J Exp Zool. 2003;6:279–84.
Duraipandiyan V, Kannan P, Ignacimuthu S. Antimicrobial Activity of Sphaeranthusindicus L. Ethnobotanical Leaflets. 2009;13:320–5.
Galani VJ, Patel BG. Effect of hydroalcoholic extract of Sphaeranthusindicus against experimentally induced anxiety, depression and convulsions in rodents. Int J Ayu Res. 2010;2 In press.
Galani VJ, Patel BG. Psychotropic activity of Sphaeranthusindicus Linn.in experimental animals. Pharmacog Res. 2009;1:307–13.
Srinivasan VM, Jessy KK, Anand Alex EM. Effect of Sphaeranthusindicus Linn. On Gentamicin induced acute renal failure in rats. Indian J Pharmacol. 2008;40:71.
Pande VV, Dubey S. Antihyperlipidemic activity of Sphaeranthusindicus on atherogenic diet induced hyperlipidemia in rats. Int J Green Pharm. 2009;3:159–61.
