Medicinal uses and pharmacological properties of Moringa oleifera

Authors

  • P. Sudhir Kumar School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Orissa, India
  • Debasis Mishra School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Orissa, India
  • Goutam Ghosh School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar, Orissa, India
  • Chandra S. Panda NISER, Institute of Physics, Bhubaneswar, Orissa, India.

Keywords:

Moringa oleifera, β –carotene, anitumor

Abstract

Moringa oleifera Lam [Moringaceae] is a highly valued plant, distributed in many countries of the tropics and subtropics. It has an impressive range of medicinal uses with high nutritional value. Different parts of this plant contain a profile of important minerals, and are a good source of protein, vitamins, β -carotene, aminoacids and various phenolics. In addition to its compelling water purifying powers and high nutritional value, M. oleifera is very important for its medicinal value. Various parts of this plant such as the leaves, roots, seed, bark, fruit, flowers and immature pods act as cardiac and circulatory stimulants, possess anitumor, antipyretic, antiepileptic, antiinflammatory, antiulcer, antispasmodic, diuretic, antihypertensive, cholesterol lowering, antioxidant, antidiabetic, hepatoprotective, antibacterial and antifungal activities, and are being employed for the treatment of different ailments in the indigenous system of medicine. This review focuses on the detailed phytochemical composition, medicinal uses, along with pharmacological properties of different parts of this multipurpose tree.

References

Oliveira JTA, Silveira SB, Vasconcelos IM,

Cavada BS, Moreira RA. 1999.

Compositional and nutritional attributes of

seeds from the multipurpose tree Moringa

oleifera Lamarck. J Sci Food Agric 79:

–820.

Nikkon F, Saud ZA, Rehman MH, Haque

ME. 2003. In vitro antimicrobial activity of

the compound isolated from chloroform

extract of Moringa oleifera Lam. Pak J Biol

Sci 22: 1888–1890.

Mughal MH, Ali G, Srivastava PS, Iqbal M.

Improvement of drumstick [Moringa

pterygosperma Gaertn.] – a unique source

of food and medicine through tissue culture.

Hamdard Med 42: 37–42.

Dahot MU. 1988. Vitamin contents of

flowers and seeds of Moringa oleifera. Pak

J Biochem 21: 1–24.

Faizi S, Siddiqui B, Saleem R, Saddiqui S,

Aftab K. 1994a. Isolation and structure

elucidation of new nitrile and mustard oil

glycosides from Moringa oleifera and their

effect on blood pressure. J Nat Prod 57:

–1261.

Faizi S, Siddiqui B, Saleem R, Siddiqui S,

Aftab K, Gilani A. 1994b. Novel

hypotensive agents, niazimin A, niazimin

B, niazicin A and niazicin B from Moringa

oleifera; Isolation of first naturally

occurring carbamates. J Chem Soc Perkin

Trans I: 3035–3640.

Faizi S, Siddiqui BS, Saleem R, Siddiqui S,

Aftab K, Gilani AH. 1995. Fully acetylated

carbamate and hypotensive thiocarbamate

glycosides from Moringa oleifera.

Phytochemistry 38:957–963.

Gilani AH, Janbaz KH, Lateef A, Zaman

M. 1994b. Cachannel blocking activity of

Artemisia scoparia extract. Phytother Res 8:

–165.

Faizi S, Siddiqui BS, Saleem R, Aftab K,

Shaheen F, Gilani AH. 1998. Hypotensive

constituents from the pods of Moringa

oleifera. Planta Med 64: 225–228.

Caceres A, Saravia A, Rizzo S, Zabala L,

Leon ED, Nave F. 1992.Pharmacologic

properties of Moringa oleifera: 2:

ScreeningCopyright © 2006 for

antispasmodic, anti-inflammatory and

diuretic activity.J Ethnopharmacol 36: 233–

Morton JF. 1991. The horseradish tree,

Moringa pterigosperma [Moringaceae]. A

boon to arid lands. Econ Bot 45: 318–333.

Ghasi S, Nwobodo E, Ofili JO. 2000.

Hypocholesterolemic effects of crude

extract of leaf of Moringa oleifera Lam in

high-fat diet fed Wistar rats. J

Ethnopharmacol 69: 21–25.

Mehta LK, Balaraman R, Amin AH, Bafna

PA, Gulati OD. 2003. Effect of fruits of

Moringa oleifera on the lipid profile of

normal and hypercholesterolaemic rabbits. J

Ethnopharmacol 86: 191–195.

Gilani AH, Aftab K, Shaheen F et al. 1992.

Antispasmodic activity of active principle

from Moringa oleifera. In Natural Drugs

and the Digestive Tract, Capasso F,

Mascolo N [eds]. EMSI: Rome, 60–63.

Dangi SY, Jolly CI, Narayana S. 2002.

Antihypertensive activity of the total

alkaloids from the leaves of Moringa

oleifera. Pharm Biol 40: 144–148.

Gilani AH, Aftab K, Suria A et al. 1994a.

Pharmacological studies on hypotensive

and spasmodic activities of pure compounds

from Moringa oleifera. Phytother Res 8:

–91.

Pal SK, Mukherjee PK, Saha BP. 1995a.

Studies on the antiulcer activity of Moringa

oleifera leaf extract on gastric ulcer models

in rats. Phytother Res 9: 463–465.

Gilani AH, Janbaz KH, Shah BH. 1997.

Quercetin exhibits hepatoprotective activity

in rats. Biochem Soc Trans 25: 85.

Das BR, Kurup PA, Rao PL, Narasimha

Rao PL. 1957. Antibiotic principle from

Moringa pterygosperma. VII. Antibacterial

activity and chemical structure of

compounds related to pterygospermin.

Indian J Med Res 45: 191–196.

Rao VA, Devi PU, Kamath R. 2001. In vivo

radioprotective effect of Moringa

Eilert U, Wolters B, Nadrtedt A. 1981. The

antibiotic principle of seeds of Moringa

oleifera and Moringa stenopetala.

PlantaMed 42: 55–61.

Bhatnagar SS, Santapau H, Desai JDH,

Yellore S, Rao TNS 1961. Biological

activity of Indian medicinal plants. Part 1.

Antibacterial, antitubercular and antifungal

action. Indian J Med Res 49: 799–805.

Caceres A, Cabrera O, Morales O,

Mollinedo P, Mendia P.

Pharmacological properties of

Moringa oleifera. 1: Preliminaryscreening

for antimicrobial activity. J Ethnopharmacol

: 213–216.

Mehta LK, Balaraman R, Amin AH, Bafna

PA, Gulati OD. 2003. Effect of fruits of

Moringa oleifera on the lipid profile of

normal and hypercholesterolaemic rabbits. J

Ethnopharmacol 86: 191–195

Nikkon F, Saud ZA, Rehman MH, Haque

ME. 2003. In vitro antimicrobial activity of

the compound isolated from chloroform

extract of Moringa oleifera Lam. Pak J Biol

Sci 22: 1888–1890.

Guevara AP, Vargas C, Sakurai H et al.

An antitumor promoter from

Moringa oleifera Lam. Mutat Res 440: 181–

Bharali R, Tabassum J, Azad MRH. 2003.

Chemomodulatory effect of Moringa

oleifera, Lam, on hepatic carcinogen

metabolizing enzymes, anti-oxidant

parameters and skin papillomagenesis in

mice. Asia Pacific J Cancer Prev4: 131–

Caceres A, Lopez S. 1991. Pharmacologic

properties of Moringa oleifera: 3: Effect of

seed extracts in the treatment of

experimental Pyodermia. Fitoterapia 62:

–450.

Murakami A, Kitazono Y, Jiwajinda S,

Koshimizu K, Ohigashi H. 1998.

Niaziminin, a thiocarbamate from the

leaves of Moringa oleifera, holds a strict

structural requirement for inhibition of

tumor-promoter-induced Epstein-Barr virus

activation. Planta Med 64: 319–323.

Pal SK, Mukherjee PK, Saha K, Pal M,

Saha BP. 1995b. Antimicrobial action of

the leaf extract of Moringa oleifera Lam.

Ancient Science of Life 14: 197–199

Tahiliani P, Kar A. 2000. Role of Moringa

oleifera leaf extract in the regulation of

thyroid hormone status in adult male and

female rats. Pharmacol Res 41: 319–323.

Makonnen E, Hunde A, Damecha G. 1997.

Hypoglycaemic effect of Moringa

stenopetala aqueous extract in rabbits.

Phytother Res 11: 147–148.

Lipipun V, Kurokawa M, Suttisri R et al.

Efficacy of Thai medicinal plant

extracts against herpes simplex virus type1

infection in vitro and in vivo. Antiviral Res

: 175–180.

Bhattacharya SB, Das AK, Banerji N. 1982.

Chemical investigations on the gum

exudates from Sonja [Moringa oleifera].

Carbohydr Res 102: 253–262.

Ndabigengesere A, Narasiah KS, Talbot

BG. 1995. Active agents and mechanism of

coagulation of turbid waters using Moringa

oleifera. Water Res 29: 703–710.

Kalogo Y, Rosillon F, Hammes F,

Verstraete W. 2000. Effect of a water

extract of Moringa oleifera seeds on the

hydrolytic microbial species diversity of a

UASB reactor treating domestic

wastewater. Lett Appl Microbiol 31: 259–

Muyibi SA, Evison LM. 1995b. Optimizing

physical parameters affecting coagulation

of turbid water with Moringa oleifera seeds.

Water Res 29: 2689–2695.

Crapper DR, Krishnan SS, Dalton AJ. 1973.

Brain aluminum distribution in Alzheimer’s

disease and experimental neurofibrillary

degeneration. Science 180: 511–513

Martyn CN, Barker DJP, Osmond C, Harris

EC, Edwardson JA, Lacey RF. 1989.

Geographical relation between Alzheimer’s

disease and aluminum in drinking water.

Lancet 1: 59–62.

Miller RG, Kopfler FC, Kelty KC, Stober

JA, Ulmer NS. 1984 . The occurrence of

aluminum in drinking water. J Am Water

Works Assoc 76: 84–91.

Obioma UN, Adikwu MU. 1997.

Investigation on some physiochemical

antioxidant and toxicological properties of

Moringa oleifera seed oil. Acta Pharm 47:

–290.

Jahn SAA. 1984. Effectiveness of

traditional flocculants asprimary coagulants

and coagulant aids for the treatment of

tropical waters with more than a thousand

fold flocculation in turbidity. Water Supply

: 8–10.

Okuda T, Baes AU, Nishijima W, Okada

M. 1999. Improvement of extraction

method of coagulation active components

from Moringa oleifera seed. Water Res 33:

–3378.

Gassenschmidt U, Jany KD, Tauscher B,

Niebergall H. 1995. Isolation and

characterization of a flocculating protein

from Moringa oleifera Lam. Biochim

Biophys Acta 1243: 477– 481.

Muyibi SA, Evison LM. 1995a. Moringa

oleifera seeds for softening hard water.

Water Res 29: 1099–1104.

Broin M, Santaella C, Cuine S, Kokou K,

Peltier G, Joet T. 2002. Flocculent activity

of a recombinant protein from Moringa

oleifera Lam. seeds. Appl Microbiol

Biotechnol 60: 114–119.

Madsen M, Schlundt J, Omer El-FE. 1987.

Effect of water coagulation by seeds of

Moringa oleifera on bacterial concentration.

J Trop Med Hyg 90: 101–109

Olsen A. 1987. Low technology water

purification by bentonite clay and Moringa

oleifera seed flocculation as performed in

Sudanese villages: effects on Schistosoma

mansoni cercariae. Water Res 21: 517–522.

Casey TJ. 1997. Unit Treatment Processes

in Water and Wastewater Engineering. John

Wiley & Sons: London.

Silvestro L, Weiser JN, Axelsen PH. 2000.

Antibacterial and antimembrane activities

of cecropin A in Escherichia coli.

Antimicrob Agents Chemother 44: 602–

Suarez M, Entenza JM, Doerries C et al.

Expression of a plant-derived peptide

harbouring water-cleaning and

antimicrobial activities. Biotechnol Bioeng

: 13–20.

Sutherland JP, Folkard G, Grant WD. 1990.

Natural coagulants for appropriate water

treatment: a novel approach. Waterlines 8:

–32.

Eilert U, Wolters B, Nadrtedt A. 1981. The

antibiotic principle of seeds of Moringa

oleifera and Moringa stenopetala.

PlantaMed 42: 55–61.

Sharma P, Kumari P, Srivastava MM,

Srivastava S. 2006. Removal of cadmium

from aqueous system by shelled Moringa

oleifera Lam. seed powder. Bioresour

Technol 97: 299–305.

Brostlap AC, Schuurmans J. 1988. Kinetics

of valine uptake in tobacco leaf disc.

Comparison of wild types the digenic

mutant and its monogenic derivatives.Planta

: 42–50.

Sharma P, Kumari P, Srivastava MM,

Srivastava S. 2006. Removal of cadmium

from aqueous system by shelled Moringa

oleifera Lam. seed powder. Bioresour

Technol 97: 299–305.

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Published

30-09-2010

How to Cite

1.
P. Sudhir Kumar, Debasis Mishra, Goutam Ghosh, Chandra S. Panda. Medicinal uses and pharmacological properties of Moringa oleifera. ijp [Internet]. 2010 Sep. 30 [cited 2024 Nov. 23];2(3):210-6. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/39

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