Neuropharmacological and biological activities of Fumaria indica

Authors

  • Mansoor Ahmad Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy University of Karachi, Karachi-75270, Pakistan
  • Meh jabeen Federal Urdu Unversity Pakistan.
  • S. Mahboob Alam Department of Pharmacology, Jinnah Post Graduate Medical Center Karachi Pakistan.
  • Noor Jahan Department of Pharmacology and Pharmacognosy, Dow college of Pharmacy, Dow University of Health Sciences Karachi, Pakistan.
  • Farah saeed Department of Pharmacology and Pharmacognosy, Dow college of Pharmacy, Dow University of Health Sciences Karachi, Pakistan.
  • Zahid Khan Department of Pharmacology & Pharmacognosy, Faculty of Pharmacy Federal Urdu University of Arts, Science & Technology, Karachi-75300, Pakistan.

Keywords:

Fumaria indica, FTIR, HPLC, Neuropharmacology

Abstract

Crude extract of Fumaria indica was assessed for neuro-pharmacological, analgesic antimicrobial and cytotoxic activities. It decreases muscle tone as indicated by swimming induced depression test (2.41/6 min, 2.56/6 min; at the dose of 500 and 300 mg/kg respectively), it also produces dose dependant (200, 300, 500 mg/kg) increase in traction time and reduces exploratory behaviour therefore, has significant muscle relaxant and anxiolytic effect (p≤0.05) as compared to standard drugs diazepam and imipramine. The results of analgesic activity (writhing and hot plate test) were highly significant as the mean number of writhes for drug treated animals was reduced (62.7% at 500 mg/kg) as compared to the control group and reference drug aspirin. The present study also revealed that the extract of F. indica has potential to inhibit the growth against different pathogenic bacteria and fungi in vivo. Over all the F. indica has significant CNS depressant action with moderate analgesic and antifungal effects.

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Published

31-03-2015

How to Cite

1.
Mansoor Ahmad, Meh jabeen, S. Mahboob Alam, Noor Jahan, Farah saeed, Zahid Khan. Neuropharmacological and biological activities of Fumaria indica. ijp [Internet]. 2015 Mar. 31 [cited 2024 Jun. 16];7(1):62-8. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/387

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