Pharmacognostic and antihyperglycemic study of Coccinia indica

Authors

  • Manish Gunjan Shri shankaracharya institute of Pharmaceutical science, Junwani, Bhilai (C.G) India.
  • Goutam K. Jana Shri shankaracharya institute of Pharmaceutical science, Junwani, Bhilai (C.G) India.
  • A. K Jha Shri shankaracharya institute of Pharmaceutical science, Junwani, Bhilai (C.G) India.
  • Umashanker Mishra Shri shankaracharya institute of Pharmaceutical science, Junwani, Bhilai (C.G) India.

Keywords:

Diabetes, Coccinia indica, Hypoglycemic activity, Chronicle administration, Indigenous herbs

Abstract

A comprehensive herbal drug therapeutic regimen offers time tested safe and effective support to conventional therapy in the management of diabetes. This is combination with adequate dietary management and physical activity would provide an integrated approach to the management of this deadly disease, particularly Type 2 diabetes. Additionally, due to unlimited potential of herbal drugs for innovative bioactive molecules, all efforts should be made to adopt a package of best practices encompassing conservation, cultivation, quality control, standardization and research and development for medicinal plants and herbals. Chronic administration of kundru fruit extracts (200mg/kg)for 14 days reduces the blood glucose level of the diabetes induced animals as compared to diabetic control group. There was significant decrease in the blood glucose level in the 7th[p<0.01] and 14th [p<0.001] days of the diabetes induction, showing antidiabetic effect of the concern fruit. The effect was comparable to that of standard antidiabetic drug Glibenclamide. The hypoglycemic effect of orally administered extracts of leaves and roots of Coccinia indica has been reported earlier but none of the literatures or paper shows the antidiabetic activity of fruit of the above plant as in crude extract while the whole fruit extract shows significant anti diabetic activity.

References

Mukerjee S.K. and Mukherjee S. Therapeutic

advances in diabetes mellitus through ages. J

Rev Indian Med. 1966; 1: 9.

Chaudhary R.R. , Udupa K.N., Chaturvedi

G.N. , Tripathi S.N. and Vohora S.B. Plants

with possible hypoglycemic activity in

advances in Research in Indian Medicine,

Banaras Hindu University, Varanasi (India);

; 57.

Karnick C.R.. Some aspects of crude Indian

drugs plants used in Ayurvedic system of

medicine (Madhumeha). Acta Phytother

Amst. 1972; 19: 141.

Satavati G.V., Raina M.K. and Sharma M.

Medicinal Plants of India, (Indian Council of

Medical Research) 1976; Vol 1.

Satyavati,G.V. Gupta A.K. and Tandon N.

Medicinal Plants of India, (Indian Council of

Medical Research, New Delhi). 1987; Vol 2.

Satyavati.G.V. Pharmacology of medicinal

plants and other natural products in current

research in Pharmacology in India.

Pharmacognosy Rev 2008; 2; 284-301.

Mukherjee S.K. Indigenous drugs in diabetes

mellitus. J Diabetic Asso India (Suppl). 1981;

: 97.

Mehta K.C. Indian herbal drugs in the

treatment of diabetes. Current Med Pract.

; 26: 305.

Nagarajan S., Jain H.C. and Aulakh G.S.

Indigenous plants used in the control of

Diabetes in ‘Cultivation and Utilization of

Medicinal Plants. Regional Research

Laboratory Jammu (India); 1982; 584.

Patnaik G.K. and Dhawan B.N.

Pharmacological studies on Indian Medicinal

plants in Current Research on Medicinal

Plants in India. Indian National Academy,

New Delhi; 1986; 45.

Das P.K., Dasgupta G. and Mishra

A.KClinical studies on Medicinal Plants of

India in Current Research of Medicinal Plants

in India. New ; 1986; 72.

Jenkins A. and Josse R.G. Effects of

processing/preparation as the blood glucose

response to potatoes in diabetic patients.

Diabetes (Suppl). 1985; 34: 32A.

Tiwari A. K., Rao M. Diabetes mellitus and

multiple therapeutic approaches of

phytochemicals: present status and future

prospects. J. Curr Sci. 2002; 83: 30.

Grover J. K, Yadav S., Vats V. Medicinal

plants of India with anti-diabetic potential. J.

Ethnopharmacol, 2002; 81: 81-100.

Tulp M., Bruhn J. G. and Bohlin LFood for

thought. Drug Discov. Today, 2006; 11:

-1121.

Zhang H.-Y. Can food-derived multipotent

agents reduce the risk of Alzheimer’s

disease? Trends Food Sci.Technology, 2007;

: 492-495.

Kumar G.P, Sudheesh,S. S. Hypoglycaemic

effect of Coccinia indica. Planta medica 1993;

: 330.

Dhawan D., Bandhu H.K., Singh Ajaib, &

Nagpal. Indian J.Pharmacol. 1996; 28: 224.

Sharma, S.R. Dwivedi S.K., Swarup D.

Journal of Ethnopharmacology 1997; 58: 39-

Snedeeor, G.W, Cochran W.G. in “Statistical

Methods”. Oxford and IBH Publishing Co.,

New Delhi, 1967; 33.

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Published

09-02-2022

How to Cite

1.
Manish Gunjan, Goutam K. Jana, A. K Jha, Umashanker Mishra. Pharmacognostic and antihyperglycemic study of Coccinia indica. ijp [Internet]. 2022 Feb. 9 [cited 2024 Apr. 19];2(1):36-40. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/14

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