A Review on Some Potential Traditional Phytomedicine with Antidiabetic Properties

Authors

  • Manish Gunjan MUCH,Ipoh, Malaysia
  • Ravindran M MUCH,Ipoh, Malaysia
  • Goutam K. Jana GCP, Sambalpur, Orissa, India

Keywords:

Diabetes, herbs, hypoglycemic agents, traditional medicines

Abstract

Diabetes is a chronic disorder of carbohydrate, fat and protein metabolism characterized by increased fasting and post prandial blood sugar levels. The global prevalence of diabetes is estimated to increase, from 4% in 1995 to 5.4% by the year 2025. WHO has predicted that the major burden will occur in developing countries? Since ancient times, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mention the use of plants in treatment of various human ailments. India has about 45000 plant species and among them, several thousands have been claimed to possess medicinal properties. Research conducted in last few decades on plants mentioned in ancient literature or used traditionally for diabetes has shown antidiabetic property. In the last few years there has been an exponential growth in the field of herbal medicine and these drugs are gaining popularity both in developing and developed countries because of their natural origin and less side effects. The present paper reviews some of such plants and their products (active, natural principles and crude extracts) that have been mentioned/used in the Indian traditional system of medicine and have shown experimental or clinical anti-diabetic activity. We believe that the list of medicinally important families and plants presented in this review is useful to researchers, as well as practitioners.

References

Grover JK, Yadav S, Vats V. Medicinal plants of

India with antidiabetic potential. J.

Ethnopharmacol. 2002;81:81–100.

Scartezzini P, Sproni E. Review on some plants

of Indian traditional medicine with antioxidant

activity. J. Ethnopharmacol. 2000;71:23–43.

Seth SD, Sharma B. Medicinal plants of India.

Indian J. Med. Res. 2004;20:9–11.

Ramachandran A, Snehalatha C, Viswanathan

V. Burden of type 2 diabetes and its

complications- the Indian scenario. Curr. Sci.

;83:1471–1476.

Matteucci E, Giampietro O. Oxidative stress in

families of type 1 diabetic patients. Diabetes

Care. 2000;23:1182–1186.

Oberlay LW. Free radicals and diabetes. Free

Radic. Biol. Med. 1988;5:113–124.

Baynes JW, Thorpe SR. The role of oxidative

stress in diabetic complications. Curr. Opin.

Endocrinol. 1997;3:277–284.

Lipinski B. Pathophysiology of oxidative stress

in diabetes mellitus. J. Diabet. Complications.

;15:203–210.

Kubish HM, Vang J, Bray TM, Phillips JP.

Targeted over expression of Cu/Zn superoxide

dismutase protects pancreatic beta cells

against oxidative stress. Diabetes.

;46:1563–1566.

Naziroglu M, Cay M. Protective role of

intraperitoneally administered vitamin E and

selenium on the oxidative defense mechanisms

in rats with diabetes induced by streptozotocin.

Biol. Stress Elem. Res. 2001;47:475–488.

Glugliano D, Ceriello A, Paolisso G. Oxidative

stress and diabetic vascular complications.

Diabet. Care. 1996;19:257–267.

Brownlee M. Advanced protein glycosylation in

diabetes in diabetes and ageing. Ann. Rev.

Med. 1996;46:223–234.

Elgawish A, Glomb M, Friendlander M, Monnier

VM. Involvement of hydrogen peroxide in

collagen cross-linking by high glucose in vitro

and in vivo. J. Biol. Chem. 1999;271:12964–

Dey L, Anoja SA, Yuan C-S. Alternative

therapies for type 2 diabetes. Alternative Med.

Rev. 2002;7:45–58.

Mukherjee SK and Mukherjee S. Therapeutic

advances in Diabetes mellitus through ages. J

Res Indian Med. 1966;1( 0:9).

Mehta KC. Indian herbal drugs in the treatment

of diabetes. Current Med Pract.

;26(10):305.

Aiman R. Recent research on indigenous

antidiabetic medicinal plants—an overall;

assessment. Indian J Physiol & Pharmacol.

;14(2):65.

Chaudhury RR and Vohora SB. Plants with

possible hypoglycaemic activity in advances in

Research in Indian Medicine, Udupa, K.N.,

Chaturvedi, G.N. and Tripathi, S.N. (Eds)

Banaras Hindu University, Varanasi (India).

;p. 57.

Karnick CR. Some aspects of crude Indian

drugs plants used in Ayurvedic system of

medicine (Madhumeha) (Diabetes). Acta

Phytother Amst. 1972;19:141.

Satyavati GV, Raina MK and Sharma M.

Medicinal Plants of India Vol. 1, Indian Council

of Medical Research. 1976.

Mukherjee SK. Indigenous drugs in Diabetes

mellitus. J Diabetic Asso India.

;21(Suppl):97.

Nagarajan S, Jain HC and Aulakh GS.

Indigenous plants used in the control of

Diabetes in 'Cultivation and Utilization of

Medicinal Plants'. Atal, C.K. and Kapur, B.M.

(Eds). Regional Research Laboratory, Jammu

(India). 1982;p. 584.

Satyavati GV. Pharmacology of medi cinal

plants and other natural products in Current

Research in Pharmacology in India (1975-

, Das, P. K. and Dhawan, B.N. (Eds),

Indian National Science Academy, New Delhi.

;p. 119

Patnaik GK and Dhawan BN. Phar macological

studies on Indian Medicinal plants in Current

Research on Medicinal Plants in India.

Dhawan, B.N. (Ed), Indian National Science

Academy, New Delhi. 1986;p. 45.

Das PK, Dasgupta G and Mishra AK. Clinical

studies on Medicinal Plants of India in Current

Research of Medi cinal Plants in India.

Dhawan, B.N. (Ed), INSA, New Delhi.

;p.72.

Satyavati GV, Gupta AK, Tandon N. Medicinal

Plants of India Vol. 2, Indian Council of Medical

Research, New Delhi. 1987.

Sever BO. Oral hypoglycemic plants in West

Africa. J Ethnopharmacol. 1980;2:109.

Handa SS, Chawla AS and Maninder.

Hypoglycemic plants—A review. Fitoterapia.

;60(3):195.

Atta-ur-Rahman and Khurshid Zaman.

Medicinal plants with hypoglycemic activity. J

Ethnopharmacol. 1989;26(2):1.

Singh KN, Chandra V and Barthwal KC.

Hypoglycemic activity of Acacia arabica, Acacia

ben.hani and Acacia modesta leguminous seed

diets in normal young albino rats. Indian J

Physiol Pharmacol. 1975;19(3):167.

Singhal PC and Joshi LD. Role of gum arabica

and gum catechu in glycaemia and

cholesterolemia. Curr Sci 1984;53:91.

Shrotri DS, Kelkar M, Deshmukh VK and Aiman

R. Investigations of hypoglycaemic properties

of Vinca rosea. Cassia aurticulata and Eugenia

jambolana. Indian J Med Res. 1963;51(3):464.

Gupta SS. Experimental studies on pituitary

diabetes Part III. Effect of indigenous

antidiabetic drugs against the acute

hyperglycaemic response of anterior pituitary

extract in glucose fed albino rats. Indian J Med

Res. 1963;51:716.

Mukherjee K, Ghosh NC and Datta T. Coccinia

indica Linn. - a potential hypoglycaemic agent.

Indian J Exp Biol. 1972;10(5):347.

Brahmachari HD and Augusti KT.

Hypoglycaemic agents from Indian indigenous

plants J Pharm (London). 1961;13(6.):381.

Rathi AN, Viswanathan A and Sundaran VKR.

Studies on the protein bound polysaccharide

components in experimental diabetes—Effect

of Gymnema Sylvestre R. Br. Indian J Exp Biol

;19:715.

Gupta SS. Effect of Gymnema sylvestre and

Pterocarpus marsupium on glucose tolerance in

albino rats. Indian J Med Sci 1963;17(6):501.

Sharma VN, Segani RK and Arora RB. Some

observations on hypogly caemic activity of

Momordica charantia. October. 1960;48(4):471.

Pabrai PR and Sehra K-B. Effect of Momordica

charantia on blood sugar in rabbits. Indian J

Pharm 1962;24:209.

Jose MP, Cheeran JV and Nair KPD. Effect of

selected indigenous drugs on the blood sugar

level in dogs. Indian J Pharmacol 1976;8:86.

Lai BN and Chaudhuri KD. Obser vations on

Momordica charantia, Linn. (Kanvelak) and

Eugenia jambolana (Jamboo) as oral

antidiabetic remedies. J Res Indian Med

(2):161.

Lotlikar MM and Rajaram Rao MR.

Pharmacology of a hypoglycaemic principle

isolated from the fruits of Momordica charantia.

Indian J Pharm 1986;28(5):129.

Khanna P, Jain SC, Panigariya and Dixit VP.

Hypoglycaemic activity of polypeptide—p from

a plant source. J Nat Prod 1981;44:648.

Shah DS. A preliminary study of the

hypoglycaemic action of heart wood of

Pterocarpus marsupium Roxb. Indian J. Med

Res 1967;55(2):166.

Pandey MC and Sharma PV. Hypoglycaemic

effect of bark of Pterocarpus marsupium Roxb

(Bijaka) an alloxan induced diabetes. Med &

Surg 1976;16(7):9.

Gupta SS and Seth CB. Experimental studies

on pituitary diabetes Part II. Comparison of

blood sugar level in normal and anterior

pituitary extract induced hyperglycaemic rats

treated with a few Ayurvedic remedies. Indian J

Med Res. 1962;50(5):708.

Gupta SS, Seth CB and Mathur VS. A few

observations in the inhibitory effect Gurmur

(Gymnema sylvestre) and Tribulus Bhasma on

anterior pituitary extract induced hypoglycaemia

in rats. Indian J Physiol Pharmacol.

;5(2):23.

Shanmugosundaram KR, Pannerselvam C,

Samudran P and Panneevselvam ERB.

Enzyme changes., and glucose utilisation in

diabetic rabbits : .The effect of Gymnema

sylvestre RBr. J Ethnopharmaol. 1983;7:205.

Chakravarthy BK, Gupta S, Gambhir SS and

Gode KD. 1-Epicatechin, a novel antidiabetic

drug. Indian Drugs 981;18:184.

Chakravarthy BK, Gupta S, Gambhir SS and

Gode KD. The psophylactic action of (—)

epicatechin against alloxan induced diabetes in

rats. Life Sci. 1981;29:2043.

Chakravarthy BK, Gupta S, Gambhir SS and

Gode KD. Pancreatic Beta cell regeneration in

rats by (—) epicatechin. Lancet

;II(8249):759.

Chakravarthy BK, Gupta S and Gode KD.

Functional beta cell regeneration in the islets of

pancreas in alloxan induced diabetic rats by

(—)-epicatechin Life Sci. 1982;31:2693.

Giri J, Sakhidevi TK and Dashyanthy N. Effect

of Jamun extract on alloxan induced diabetes in

rats J Diab Assoc India 1985;25:115.

Bhaskaran R and Santhakumari G. Antidiabetic

activity of the seed kernel of Syzygium Cumini

Ancient Sci Life. 1986;6:80.

Baldwa VS, Goyal RK, Bhandari CM and

Panagariya A. A clinical trial of insulin obtained

from vegetable source (plant insulin) in patients

with diabetes mellitus. Rajasthan Med J

;15(1):54.

Rastogi RP and Dhawan BN. Research on

medicinal plants at CDRI, Lucknow. Indian J

Med Res 1982;76 (Suppl):27.

Kulkarni RD and Gaitonde BB. Potentiation of

tolbutamide action by Jased Bhasma and

Karela (Momordica charantia). Indian J Med

Res 1962;50:715.

Kolb H, Kiesel U, Greulich B and VanDer Bosh.

Lack of antidiabetic effect of (—)-epicatechin.

Lanbet 1982;I(8284):1303.

Sheehan EW, Stiff DD, Duah F, Slatkin DJ,

Schiff PL. (Jr) and Zemaitis, M.A. The lack of

effectiveness of (—) epicatechin against alloxan

induced diabetes in Wistar rats. Life Sci.

;33:593.

Kyle PR, Barker J, Gaines PA, Thomson AD

and Chakraborty J. Alloxan-induced diabetes in

the rat. Protective action of (—)-epicatechin.

Life. Sci. 1984;34:591.

Pillai NR, Seshadri S and Santhakumari S.

Hypoglycaemic activity of Salacia prenodes.

Indian J Exp Biol.1979;17:1279.

Downloads

Published

31-12-2011

How to Cite

1.
Manish Gunjan, Ravindran M, Goutam K. Jana. A Review on Some Potential Traditional Phytomedicine with Antidiabetic Properties. ijp [Internet]. 2011 Dec. 31 [cited 2024 Jun. 13];3(4):448-5. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/125

Issue

Section

Review Article