A Brief Review on Phytoconstituents and Ethnopharmacology of Scoparia Dulcis Linn. (Scrophulariaceae)
Keywords:
Scoparia dulcis, scoparic acid, ammelin, medicinal effectAbstract
Scoparia dulcis Linn.(S. dulcis)or sweet broom weed commonly known as Mithipatti and Bana Dhania in Western Orissa, it is also known as ‘GhodaTulsi’in Hindi. The present review attempts to narrate the chemical constituents of S.dulcis and their uses. S.dulcis is rich in flavones, terpenes and steroids. Main chemical constituents such as scoparic acid A-C, scopadulcic acid A and B, scopadulciol, scopadulin and ammelin have been shown to contribute to the observed medicinal effect of the plant. In this review we have composed the structure and functions of those active ingredients with their melting point and other physical properties individually.Some aspects of the several speculated pharmacological properties of S. dulcis have been validated by scientific research, which includes the presence of hypoglycaemic and antitumour promoting compound. It also has antimicrobial and antifungal effects as well as antihyperlipidemic action.
References
Branch LC, IMF da Silva. Folk medicine of Alter
does chao, para. Branza Acta Amazonica.
;(13):737-767.
Satyanarayana K. Chemical examination of
Scoparia dulcis (Linn.) Part-I.J. Indian Chem. Soc.
;(46):765-766.
Edeoga HO, Okwu DE and Mbaebie BO.
Phytochemical constituents of some Nigerian
medicinal Plants. African Journal of Biotechnology
July 2005;Vol. 4(7):pp. 685-688.
Chow SY, S.M.Chen, C.M. Yang. H.Hsu.
Pharmacological studies on Chinese herbs. 1.
Hypotensive effect of 30 Chinese herbs. Taiwan Yi
Xue Za Zhi. 1974;(73):729-739.
Hayashi K, Toshimitsu H, Naokata M. Cytotoxic
and antitumor activity of scopadulcic acid from
Scoparia dulcis L. Phytother Res 1992;6:6-9.
Asano S, Mizutani M, Hayashi T, Morita N,
Takeguchi N. Reversible inhibitions ofgastric H+
K+ ATPase by scopadulcic acid B and diacetyl
scopadol: Newbiochemical tools of H+ K+ ATPase.
J Biol Chem 1990;265:22167-22173.
Hayashi K, Jung BL, Yoshie M, Naoki T, Hideo N,
Toshimitsu Hayashi. The role ofa HSV thymidine
kinase stmulating substance scopadulciol in
improving the efficacyof cancer gene therapy. J
Gene Med 2006;8:1056-1062.
The Wealth of India. A Dictionary of Indian
Medicinal and Industrial Product. First supp. Series
(Raw materials) 5V, National Institute of science
communication and information resources, CSIR,
New Delhi. 2004; p. 87.
Ayurvedic Pharmacopoeia of India, 2001. Indian
system of Medicine & Homeopathy, Govt. of India
Ministry of Health and Family Welfare, The
Controller of Publication Civil Lines, Delhi, I ed.
;V –III: p.234.
Branch LC, daSilva IMF. Folk medicine of Alter do
chao, Para, Brazil, Acta Amazonica,
;13(5/6):737-797.
Denis P. Herbal Medicine among the Miskito of
Eastern Nicaragua. Econ.Bot. 1988;42(1):16-28.
Hayashi T., Kishi M., Kawasaki M., Arisawa M.,
Shimizu M., Suzuki S., Yoshizaki M., Morita N,
Tezuka Y, Kikuchi T, Berganza LH, Ferro E,
Basualdo I. Scopadulcic acid-A and -B, new
diterpenoids with a novel skeleton, from a
Paraguayan crude drug “typychá kuratũ” (Scoparia
dulcis L.).Tetrahedron Lett. 1987;(28):3693–3696.
Hayashi T, Okamura K, Kakemi M, Asano S,
Mizutani M, Takeguchi N, Kawasaki M, Tezuka Y,
Kikuchi T, Morita N, Chem. Pharm. Bull.
;38(10):2740–2745.
Kawasaki M, Hayashi T, Arisawa M, Shimizu M,
Horie S, Ueno H, Syogawa H, Suzuki S, Yoshizaki
M, Morita N, Tezuka Y, Kikuchi T, Berganza LH,
Ferro E, Basualdo I, Structure of scoparic acid A, a
new labdane-type diterpenoid from a paraguayan
crude drug "typycha kurata" (Scoparia dulcis l.).
Chem. Pharm. Bull. 1987;(35)3963–3966.
Hayashi T, Kawasaki M, Okamura K, Tamada Y,
Morita N, Tezuka Y, Kikuchi T, Miwa Y, Taga T,
Scoparic acid A, a beta-glucuronidase inhibitor
from Scoparia dulcis. J. Nat. Prod.,
;(55)1748–1755.
Hee-Kap Kang, Diane Ecklund, Michael
Liu,Syamal K Datta http://arthritisresearch.com/content/11/2/R59. 09/02/12
naturactiva.net/articles/benefits_shea_butter.doc .
/02/12
http://www.alibaba.com/showroom/acacetin.ht
ml. 09/02/12
Hashimoto N, Yamashita T, Tsuruzoe N.
Tertiapin, a selective IKACh blocker, terminates
atrial fibrillation with selective atrial effective
refractory period prolongation. Pharmacol Res.
;(54):136 –141.
http://circ.ahajournals.org/cgi/content/full/CIRC
ULATIONAHA.108.769554/DC1
Faujan NH, Alitheen NB, Yeap SK, Ali AM, Muhajir
AH, Ahmad FBH. Cytotoxic effect of betulinic acid
and betulinic acid acetate isolated from Melaleuca
cajuput on human myeloid leukemia (HL-60) cell
line. African Journal of Biotechnology.
;9(38):6387-6396.
Perumal Yogeeswari,Dharmarajan Sriram.
Betulinic Acid and Its Derivatives: A Review on
their Biological Properties . Current Medicinal
Chemistry. 2005;(12):657-666.
Simone Fulda. Betulinic Acid for Cancer Treatment
and Prevention. .Int. J. Mol. Sci. 2008;(9):1096-
Zikmundova M., Drandarov K., Bigler L., Hesse M.,
Werner C. Biotransformation of 2-Benzoxazolinone
and 2-Hydroxy-1,4-Benzoxazin-3-one by
Endophytic Fungi Isolated from Aphelandra
tetragona. Applied And Environmental
Microbiology. 2002;68(10):4863–4870.
http://www.znaturforsch.com/ac/v59c/s59c017
pdf. 09/02/12
Girotti C., Ginet M., Demarne F.C., Lagarde M.,
Géloën A. Lipolytic activity of cirsimarin extracted
from Microtea debilis.Planta Med.
;71(12):1170-2.
www.chemblink.com/products/13020-19-
htm. 09/02/12
Saikat Sen, Raja Chakraborty, Biplab De, Joydeep
Mazumder. Plants and phytochemicals for peptic
ulcer: An overview. Phcog Rev. 2009;3:(6):270-
Park JC, Park JG, Kim HJ, Hur JM, Lee JH,
Sung NJ, Chung SK, Choi JW. Effects of extract
from Angelica keiskei and its component,
cynaroside, on the hepatic bromobenzenemetabolizing enzyme system in rats. Phytother
Res. 2002;16 1:S24-7.
Xiao Sun, Gui-boSun, MinWang,Jing Xiao,Xiao-bo
Sun. Protective effects of cynaroside against
H2O2-induced apoptosis in H9c2 cardiomyoblasts.
Journal of Cellular Biochemistry.
;112(8)2019–2029.
Ferguson LR, Shuo-tun Z, Harris PJ. Antioxidant
and antigenotoxic effects of plant cell wall
hydroxycinnamic acids in cultured HT-29.
Molecular Nutrition & Food Research.
;49(6)585–693.
www.chemblink.com/products/608-66-2.htm.
/02/12
Lee JH, Lee JY, Park JH, Jung HS, Kim JS,
Kang SS, Kim YS, Han Y. Immunoregulatory
activity by daucosterol, a beta-sitosterol glycoside,
induces protective Th1 immune response against
disseminated Candidiasis in mice. Vaccine,
;25(19):3834-40.
Moore WE, Bope FW, Christensens BV. Some
new derivatives of gentisic acid. II.
Pharmacological tests upon some new derivatives
of gentisic acid. Journal of the American
Pharmaceutical Association. 1954:6(43):334–337.
www.chemblink.com/products/559-74-0.htm.
/02/12
www.molecularnetworks.com/biopath3/biopath/mols/Glutinol.
/02/12
Kamaliah Mahmood, Hapipah Mohd Ali, Rohana
Yusof, Hamid Hadi A, Mary Pais. Chemical
Components from the Light Petroleum Soluble
Fraction of Uvaria cordata (Dunal) Alston.
Pertanika J. Sci. & Techno. 1995;3(2):197-202.
Watson WH, Kashyap RP, Gao F, Mabry TJ.
Structure of the flavone hymenoxin.
ActaCrystallogr C. 1991;15(47)(Pt 2):459-61.
Atta-ur- Rahman, Studies in Natural Products
Chemistry, Bioactive Natural Products, 1st Edn.
Elsevier. 2005;Volume 32:pp.1127-1201.
www.tradingchem.com/Ifflaionic_acid/6805-19-
html. 09/02/12
Atta-ur- Rahman, Studies in Natural Products
Chemistry, Bioactive Natural Products (Part B),
Part 2, 1st Edn. Elsevier. 2000;pp.690-693.
Sebastián Fernández, Cristina Wasowski,
Alejandro C Paladini, Mariel Marder. Sedative and
sleep-enhancing properties of linarin, a flavonoidisolated from Valeriana officinalis. Pharmacology
Biochemistry and Behavior. 2004;77(2):399-404.
Chowdhury AR, Sharma S, Mandal S, Goswami A,
Mukhopadhyay S, Majumder HK. Luteolin, an
emerging anti-cancer flavonoid, poisons eukaryotic
DNA topoisomerase Biochem. J. 2002;366:653-
en.wikipedia.org/wiki/Luteolin. 09/02/12
Kelley KW, Johnson RW. Luteolin reduces IL-6
production in microglia by inhibiting JNK
phosphorylation and activation of AP-1. Proc. Natl.
Acad. Sci. U.S.A. 2008;105(21):7534–9.
Mann John., Secondary Metabolism. 2nd Edn,
Oxford, UK: Oxford University Press.
;pp.279–280.
Ikeda M, Bhattacharjee AK, Kondoh T, Nagashima
T, Tamaki N. Synergistic Effect of Cold Mannitol
and Na+/Ca2+ Exchange Blocker on Blood–Brain
Barrier Opening Biochem. Biophys. Res. Commun.
;291:669-674.
http://en.wikipedia.org/wiki/Mannitol. 09/02/12
http://www.chemicalbook.com/Search_EN.asp
x?keyword=Scutellarein. 09/02/12
www.chemfaces.com/manual/ScoparinolCFN99397.pdf. 09/02/12
Bouic PJ. The Role of Phytosterols and
Phytosterolins in Immune Modulation: A Review of
the Past 10 Years. CurrOpinClinNutrMetabCare.
; 4 :471-475.
www.selleckchem.com/products/Stigmasterol(
Stigmasterin).html. 09/02/12
Panda S, Jafri M, Kar A and Meheta BK. Thyroid
inhibitory, antiperoxidative and hypoglycemic
effects of stigmasterol isolated from Butea
monosperma. Fitoterapia. 2009;80(2):123-126.
http://www.drugfuture.com/chemdata/luteolin.h
tml. 09/02/12
Nagaprashantha LD, Vatsyayan R, Singhal J, Fast
S, Roby R, Awasthi S, Singhal SS. Anti-cancer
effects of novel flavonoid vicenin-2 as a single
agent and in synergistic combination with
docetaxel in prostate cancer. BiochemPharmacol,
;82(9):1100-9
http://pubchem.ncbi.nlm.nih.gov/summary/sum
mary.cgi?sid=12381. 09/02/12
http://www.jstage.jst.go.jp/article/cpb/51/10/51
_1204/_article/-char/en. 09/02/12.
Kim JH, Lee BC, Kim JH, Sim GS, Lee DH, Lee
KE, Yun YP, Pyo HB. The isolation and
antioxidative effects of vitexin from Acer
palmatum. Arch Pharm Res. 2005;28(2):195-202.
en.wikipedia.org/wiki/Vitexin. 09/02/12
Freire SMF, Torres LMB, Roque NF, Souccar C.
Analgesic activity of a triterpene isolated from
ScopariadulcisL. (Vassourinha). Memórias do
InstitutoOswaldo Cruz. 1991;(86):149-151.
FariasFreie SM, Silva Emin JA, Lapa AJ, Souccar
C &Brandao Torres LM. Analgesic and antiinflammatory properties of Scoparia dulcis L.
extract and glutinol in rodents. Phytotherapy
Research. 1993;(7):408-414.
Ahmed M, Shikha HA, Sadhu SK, Rahman MT,
Datta BK. Analgesic, diuretic, and antiinflammatory principle from Scopariadulcis.
Pharmazie, 2001;56(8):657-660
Latha M, Pari L, Sitasawad S, Bhonde R. Insulin
secretagogue activity and cytoprotective role of the
traditional antidiabetic plant Scoparia dulcis ,Life
Sci. 2004;75(16):2003-2014.
Pari L, Latha M. Antihypoglycaemic activity of
Scopariadulcis: effect on key metabolic enzymes
of carbohydrate metabolism in streptozotocininduced diabetes. Pharm. Biol. 2004;42(8):570-
Pari L, Venkateswaran. Hypoglycaemic activity of
Scopariadulcis L. extract in alloxan-induced
hyperglycaemic rats, PPhytotherapy Research.
;16(7):662- 664.
Nishino H Anti-tumor promoting activity of
Scopadulcic Acid B, Isolated from the medicinal
plant Scoparia dulcis. L. Oncology.
;50(2):100-103.