A Brief Review on Phytoconstituents and Ethnopharmacology of Scoparia Dulcis Linn. (Scrophulariaceae)


  • Manas Ranjan Mishra Associate Professor, Gayatri College of Pharmacy,Jamadarpali, Sason, Sambalpur, Odisha-768200
  • R.K. Behera Gayatri College of Pharmacy,Jamadarpali, Sason, Sambalpur, Odisha-768200
  • S. Jha Birla Institute of Technology, Mesra, Ranchi, Jharkhand.
  • A. Mishra Gayatri College of Pharmacy,Jamadarpali, Sason, Sambalpur, Odisha-768200
  • D.K. Pradhan Gayatri College of Pharmacy,Jamadarpali, Sason, Sambalpur, Odisha-768200
  • P.R. Choudary The Pharmaceutical College, Barpali, Bargarh, Odisha.


Scoparia dulcis, scoparic acid, ammelin, medicinal effect


Scoparia dulcis Linn.(S. dulcis)or sweet broom weed commonly known as Mithipatti and Bana Dhania in Western Orissa, it is also known as ‘GhodaTulsi’in Hindi. The present review attempts to narrate the chemical constituents of S.dulcis and their uses. S.dulcis is rich in flavones, terpenes and steroids. Main chemical constituents such as scoparic acid A-C, scopadulcic acid A and B, scopadulciol, scopadulin and ammelin have been shown to contribute to the observed medicinal effect of the plant. In this review we have composed the structure and functions of those active ingredients with their melting point and other physical properties individually.Some aspects of the several speculated pharmacological properties of S. dulcis have been validated by scientific research, which includes the presence of hypoglycaemic and antitumour promoting compound. It also has antimicrobial and antifungal effects as well as antihyperlipidemic action.


Branch LC, IMF da Silva. Folk medicine of Alter

does chao, para. Branza Acta Amazonica.


Satyanarayana K. Chemical examination of

Scoparia dulcis (Linn.) Part-I.J. Indian Chem. Soc.


Edeoga HO, Okwu DE and Mbaebie BO.

Phytochemical constituents of some Nigerian

medicinal Plants. African Journal of Biotechnology

July 2005;Vol. 4(7):pp. 685-688.

Chow SY, S.M.Chen, C.M. Yang. H.Hsu.

Pharmacological studies on Chinese herbs. 1.

Hypotensive effect of 30 Chinese herbs. Taiwan Yi

Xue Za Zhi. 1974;(73):729-739.

Hayashi K, Toshimitsu H, Naokata M. Cytotoxic

and antitumor activity of scopadulcic acid from

Scoparia dulcis L. Phytother Res 1992;6:6-9.

Asano S, Mizutani M, Hayashi T, Morita N,

Takeguchi N. Reversible inhibitions ofgastric H+

K+ ATPase by scopadulcic acid B and diacetyl

scopadol: Newbiochemical tools of H+ K+ ATPase.

J Biol Chem 1990;265:22167-22173.

Hayashi K, Jung BL, Yoshie M, Naoki T, Hideo N,

Toshimitsu Hayashi. The role ofa HSV thymidine

kinase stmulating substance scopadulciol in

improving the efficacyof cancer gene therapy. J

Gene Med 2006;8:1056-1062.

The Wealth of India. A Dictionary of Indian

Medicinal and Industrial Product. First supp. Series

(Raw materials) 5V, National Institute of science

communication and information resources, CSIR,

New Delhi. 2004; p. 87.

Ayurvedic Pharmacopoeia of India, 2001. Indian

system of Medicine & Homeopathy, Govt. of India

Ministry of Health and Family Welfare, The

Controller of Publication Civil Lines, Delhi, I ed.

;V –III: p.234.

Branch LC, daSilva IMF. Folk medicine of Alter do

chao, Para, Brazil, Acta Amazonica,


Denis P. Herbal Medicine among the Miskito of

Eastern Nicaragua. Econ.Bot. 1988;42(1):16-28.

Hayashi T., Kishi M., Kawasaki M., Arisawa M.,

Shimizu M., Suzuki S., Yoshizaki M., Morita N,

Tezuka Y, Kikuchi T, Berganza LH, Ferro E,

Basualdo I. Scopadulcic acid-A and -B, new

diterpenoids with a novel skeleton, from a

Paraguayan crude drug “typychá kuratũ” (Scoparia

dulcis L.).Tetrahedron Lett. 1987;(28):3693–3696.

Hayashi T, Okamura K, Kakemi M, Asano S,

Mizutani M, Takeguchi N, Kawasaki M, Tezuka Y,

Kikuchi T, Morita N, Chem. Pharm. Bull.


Kawasaki M, Hayashi T, Arisawa M, Shimizu M,

Horie S, Ueno H, Syogawa H, Suzuki S, Yoshizaki

M, Morita N, Tezuka Y, Kikuchi T, Berganza LH,

Ferro E, Basualdo I, Structure of scoparic acid A, a

new labdane-type diterpenoid from a paraguayan

crude drug "typycha kurata" (Scoparia dulcis l.).

Chem. Pharm. Bull. 1987;(35)3963–3966.

Hayashi T, Kawasaki M, Okamura K, Tamada Y,

Morita N, Tezuka Y, Kikuchi T, Miwa Y, Taga T,

Scoparic acid A, a beta-glucuronidase inhibitor

from Scoparia dulcis. J. Nat. Prod.,


Hee-Kap Kang, Diane Ecklund, Michael

Liu,Syamal K Datta http://arthritisresearch.com/content/11/2/R59. 09/02/12

naturactiva.net/articles/benefits_shea_butter.doc .



ml. 09/02/12

Hashimoto N, Yamashita T, Tsuruzoe N.

Tertiapin, a selective IKACh blocker, terminates

atrial fibrillation with selective atrial effective

refractory period prolongation. Pharmacol Res.

;(54):136 –141.



Faujan NH, Alitheen NB, Yeap SK, Ali AM, Muhajir

AH, Ahmad FBH. Cytotoxic effect of betulinic acid

and betulinic acid acetate isolated from Melaleuca

cajuput on human myeloid leukemia (HL-60) cell

line. African Journal of Biotechnology.


Perumal Yogeeswari,Dharmarajan Sriram.

Betulinic Acid and Its Derivatives: A Review on

their Biological Properties . Current Medicinal

Chemistry. 2005;(12):657-666.

Simone Fulda. Betulinic Acid for Cancer Treatment

and Prevention. .Int. J. Mol. Sci. 2008;(9):1096-

Zikmundova M., Drandarov K., Bigler L., Hesse M.,

Werner C. Biotransformation of 2-Benzoxazolinone

and 2-Hydroxy-1,4-Benzoxazin-3-one by

Endophytic Fungi Isolated from Aphelandra

tetragona. Applied And Environmental

Microbiology. 2002;68(10):4863–4870.


pdf. 09/02/12

Girotti C., Ginet M., Demarne F.C., Lagarde M.,

Géloën A. Lipolytic activity of cirsimarin extracted

from Microtea debilis.Planta Med.



htm. 09/02/12

Saikat Sen, Raja Chakraborty, Biplab De, Joydeep

Mazumder. Plants and phytochemicals for peptic

ulcer: An overview. Phcog Rev. 2009;3:(6):270-

Park JC, Park JG, Kim HJ, Hur JM, Lee JH,

Sung NJ, Chung SK, Choi JW. Effects of extract

from Angelica keiskei and its component,

cynaroside, on the hepatic bromobenzenemetabolizing enzyme system in rats. Phytother

Res. 2002;16 1:S24-7.

Xiao Sun, Gui-boSun, MinWang,Jing Xiao,Xiao-bo

Sun. Protective effects of cynaroside against

H2O2-induced apoptosis in H9c2 cardiomyoblasts.

Journal of Cellular Biochemistry.


Ferguson LR, Shuo-tun Z, Harris PJ. Antioxidant

and antigenotoxic effects of plant cell wall

hydroxycinnamic acids in cultured HT-29.

Molecular Nutrition & Food Research.




Lee JH, Lee JY, Park JH, Jung HS, Kim JS,

Kang SS, Kim YS, Han Y. Immunoregulatory

activity by daucosterol, a beta-sitosterol glycoside,

induces protective Th1 immune response against

disseminated Candidiasis in mice. Vaccine,


Moore WE, Bope FW, Christensens BV. Some

new derivatives of gentisic acid. II.

Pharmacological tests upon some new derivatives

of gentisic acid. Journal of the American

Pharmaceutical Association. 1954:6(43):334–337.





Kamaliah Mahmood, Hapipah Mohd Ali, Rohana

Yusof, Hamid Hadi A, Mary Pais. Chemical

Components from the Light Petroleum Soluble

Fraction of Uvaria cordata (Dunal) Alston.

Pertanika J. Sci. & Techno. 1995;3(2):197-202.

Watson WH, Kashyap RP, Gao F, Mabry TJ.

Structure of the flavone hymenoxin.

ActaCrystallogr C. 1991;15(47)(Pt 2):459-61.

Atta-ur- Rahman, Studies in Natural Products

Chemistry, Bioactive Natural Products, 1st Edn.

Elsevier. 2005;Volume 32:pp.1127-1201.


html. 09/02/12

Atta-ur- Rahman, Studies in Natural Products

Chemistry, Bioactive Natural Products (Part B),

Part 2, 1st Edn. Elsevier. 2000;pp.690-693.

Sebastián Fernández, Cristina Wasowski,

Alejandro C Paladini, Mariel Marder. Sedative and

sleep-enhancing properties of linarin, a flavonoidisolated from Valeriana officinalis. Pharmacology

Biochemistry and Behavior. 2004;77(2):399-404.

Chowdhury AR, Sharma S, Mandal S, Goswami A,

Mukhopadhyay S, Majumder HK. Luteolin, an

emerging anti-cancer flavonoid, poisons eukaryotic

DNA topoisomerase Biochem. J. 2002;366:653-

en.wikipedia.org/wiki/Luteolin. 09/02/12

Kelley KW, Johnson RW. Luteolin reduces IL-6

production in microglia by inhibiting JNK

phosphorylation and activation of AP-1. Proc. Natl.

Acad. Sci. U.S.A. 2008;105(21):7534–9.

Mann John., Secondary Metabolism. 2nd Edn,

Oxford, UK: Oxford University Press.


Ikeda M, Bhattacharjee AK, Kondoh T, Nagashima

T, Tamaki N. Synergistic Effect of Cold Mannitol

and Na+/Ca2+ Exchange Blocker on Blood–Brain

Barrier Opening Biochem. Biophys. Res. Commun.


http://en.wikipedia.org/wiki/Mannitol. 09/02/12


x?keyword=Scutellarein. 09/02/12

www.chemfaces.com/manual/ScoparinolCFN99397.pdf. 09/02/12

Bouic PJ. The Role of Phytosterols and

Phytosterolins in Immune Modulation: A Review of

the Past 10 Years. CurrOpinClinNutrMetabCare.

; 4 :471-475.


Stigmasterin).html. 09/02/12

Panda S, Jafri M, Kar A and Meheta BK. Thyroid

inhibitory, antiperoxidative and hypoglycemic

effects of stigmasterol isolated from Butea

monosperma. Fitoterapia. 2009;80(2):123-126.


tml. 09/02/12

Nagaprashantha LD, Vatsyayan R, Singhal J, Fast

S, Roby R, Awasthi S, Singhal SS. Anti-cancer

effects of novel flavonoid vicenin-2 as a single

agent and in synergistic combination with

docetaxel in prostate cancer. BiochemPharmacol,



mary.cgi?sid=12381. 09/02/12


_1204/_article/-char/en. 09/02/12.

Kim JH, Lee BC, Kim JH, Sim GS, Lee DH, Lee

KE, Yun YP, Pyo HB. The isolation and

antioxidative effects of vitexin from Acer

palmatum. Arch Pharm Res. 2005;28(2):195-202.

en.wikipedia.org/wiki/Vitexin. 09/02/12

Freire SMF, Torres LMB, Roque NF, Souccar C.

Analgesic activity of a triterpene isolated from

ScopariadulcisL. (Vassourinha). Memórias do

InstitutoOswaldo Cruz. 1991;(86):149-151.

FariasFreie SM, Silva Emin JA, Lapa AJ, Souccar

C &Brandao Torres LM. Analgesic and antiinflammatory properties of Scoparia dulcis L.

extract and glutinol in rodents. Phytotherapy

Research. 1993;(7):408-414.

Ahmed M, Shikha HA, Sadhu SK, Rahman MT,

Datta BK. Analgesic, diuretic, and antiinflammatory principle from Scopariadulcis.

Pharmazie, 2001;56(8):657-660

Latha M, Pari L, Sitasawad S, Bhonde R. Insulin

secretagogue activity and cytoprotective role of the

traditional antidiabetic plant Scoparia dulcis ,Life

Sci. 2004;75(16):2003-2014.

Pari L, Latha M. Antihypoglycaemic activity of

Scopariadulcis: effect on key metabolic enzymes

of carbohydrate metabolism in streptozotocininduced diabetes. Pharm. Biol. 2004;42(8):570-

Pari L, Venkateswaran. Hypoglycaemic activity of

Scopariadulcis L. extract in alloxan-induced

hyperglycaemic rats, PPhytotherapy Research.

;16(7):662- 664.

Nishino H Anti-tumor promoting activity of

Scopadulcic Acid B, Isolated from the medicinal

plant Scoparia dulcis. L. Oncology.





How to Cite

Manas Ranjan Mishra, R.K. Behera, S. Jha, A. Mishra, D.K. Pradhan, P.R. Choudary. A Brief Review on Phytoconstituents and Ethnopharmacology of Scoparia Dulcis Linn. (Scrophulariaceae). ijp [Internet]. 2011 Dec. 31 [cited 2024 Jun. 23];3(4):422-38. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/123



Review Article