Potential antioxidant and hypoglycaemic effect of the flower extract of Bougainvillea spectabilis Willd. (Nyctaginaceae)


  • Fave Yohanna Tata Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria
  • Hafsat Ali Sa’ab Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria
  • Abdulkadir Bukar Bababe Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria
  • Muhammad Mustapha Hassan Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria
  • Wazis Chama Haruna Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria
  • Cletus Anes Ukwubile Department of Pharmacognosy, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria


Alloxan, antioxidant, Bougainvillea spectabilis, DPPH, hyperglycaemia


The study evaluated the antioxidant and hypoglycaemic potentials of the ethanol flower extract of Bougainvillea spectabilis. Flower extract of Bougainvillea spectabilis were obtained by cold maceration method. The preliminary phytochemical screening and hypoglycaemic effect were carried out using standard methods. Antioxidant screening was carried out using DPPH antioxidant assay test. Five rats were used for each group; normal control, standard control, 100, 200 and 400 mg/kg b.w. doses of the crude ethanol flower extract of B. spectabilis to test the hypoglycaemic effect in alloxan-induced diabetic rats. Blood glucose levels were measured at different time intervals. The preliminary phytochemical screening revealed the presence of alkaloids, saponins, strerols, terpenoids, flavonoids, and carbohydrates. The crude ethanol fraction demonstrated least antioxidant activity while the chloroform fraction showed the highest antioxidant activity followed by the hexane fraction. The ethanol flower extract showed a significant dose dependent hypoglyceamic effect after 24 hours of administration. Of the doses tested, highest hypoglycaemic effect was observed by the ethanol flower extract of the dose 400 mg/kg at 24 hours. The findings revealed that non-polar fractions have more antioxidant activity than the polar fractions while the ethanol flower extract of Bougainvillea spectabilis possesses a delayed hypoglycaemic effect.


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How to Cite

Fave Yohanna Tata, Hafsat Ali Sa’ab, Abdulkadir Bukar Bababe, Muhammad Mustapha Hassan, Wazis Chama Haruna, Cletus Anes Ukwubile. Potential antioxidant and hypoglycaemic effect of the flower extract of Bougainvillea spectabilis Willd. (Nyctaginaceae). ijp [Internet]. 2021 Mar. 31 [cited 2024 Apr. 24];13(1):09-15. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/648



Original Research Articles