Isodon rugosus as potential source of phytopharmacological agents: A review

Authors

  • Muhammad Muneeb Ahmad Research scholar at department of chemistry, Government College University Faisalabad Pakistan

Keywords:

Isodon rugosus, bioactive compounds, pharmacological activities

Abstract

This piece of writing is aimed to attract the concern of readers and researchers toward the natural bioactive compounds hidden in the depth of natural life. Plant based bioactive compounds have become first choice as a potential source of pharmacological agents. Families of bioactive compounds such as flavonoids, polyphenols, carotenoids, diterpenes, sterols and vitamins enlist the class of naturally occurring families of organic compounds that are widely utilized for the maintenance of natural life. Isodon rugosus is one of the richest plants of Lamiaceae family which contain plenty of biological active compounds. In this review we will focus on labeling and exploring the biological importance of Isodon rugosus. Isodon rugosus plays meaningful role by performing biological activities such as antibacterial, antioxidant, antifungal, anticancer, insecticidal, analgesic and ethnobotanical activities. The strong bioactive potential of Isodon rugosus may act as a key factor to researchers for doing further research work on entire plant to introduce it in pharmacological agents to make the life more sustainable.

References

Znini M, Manssouri M, Ansari A, Costa J, Majidi L: Comparative chemical analysis of volatile compounds of Warionia saharea leaves using hydrodistillation and headspace solid-phase microextraction (HS-SPME). Moroccan Journal of Chemistry, 7(4):7-4 (2019) 2765-2773. 2. Ayaz M, Junaid M, Ullah F, Sadiq A, Subhan F, Khan MA, Ahmad W, Ali G, Imran M, Ahmad S: Molecularly characterized solvent extracts and saponins from Polygonum hydropiper L. show high anti-angiogenic, anti-tumor, brine shrimp, and fibroblast NIH/3T3 cell line cytotoxicity. Frontiers in pharmacology 2016, 7:74. 3. Khan Au, Gilani AH: Natural Products Useful in Respiratory Disorders: Focus on Side‐Effect Neutralizing Combinations. Phytotherapy Research 2015, 29(9):1265-1285. 4. Haq F, Ahmad H, Ullah R, Iqbal Z: Species diversity and ethno botanical classes of the flora of Allai valley district Battagram Pakistan. International Journal of Plant Research 2012, 2(4):111-123. 5. Khan SU, Khan A-u, Shah A-u-HA, Shah SM, Hussain S, Ayaz M, Ayaz S: Heavy metals content, phytochemical composition, antimicrobial and insecticidal evaluation of Elaeagnus angustifolia. Toxicology and industrial health 2016, 32(1):154-161. 6. Bouzidi N, Mederbal K, Bouhadi D: Chemical composition of the essential oil of Satureja calamintha subsp. Nepeta of west Algerian. MOROCCAN JOURNAL OF CHEMISTRY 2018, 6(2):213-217. 7. Ozen T, Telci I, Gul F, Demirtas I: A Comprehensive Study on Phytochemical Contents, Isolation and Antioxidant Capacities in wild mind, Mentha longifolia subsp. typhoides var. typhoides. Moroccan Journal of Chemistry 2018, 6(4):601-614. 8. Shuaib M, Khan I: Study of Medicinal Plants of Lower Dir, Timergara, Tehsil Balambat, Khyber Paktunkhaw-Pakistan. Am Eurasian J Agric Environ Sci 2015, 15:2088-2094. 9. Akhtar N, Rashid A, Murad W, Bergmeier E: Diversity and use of ethno-medicinal plants in the region of Swat, North Pakistan. Journal of ethnobiology and ethnomedicine 2013, 9(1):25. 10. Sabeen M, Ahmad SS: Exploring the folk medicinal flora of Abbotabad city, Pakistan. Ethnobotanical Leaflets 2009, 2009(7):1. 11. Ahmad M, Sultana S, Fazl-i-Hadi S, Ben Hadda T, Rashid S, Zafar M, Khan MA, Khan MPZ, Yaseen G: An Ethnobotanical study of Medicinal Plants in high mountainous region of Chail valley (District Swat-Pakistan). Journal of ethnobiology and ethnomedicine 2014, 10(1):36. 12. Adnan M, Begum S, Khan AL, Tareen AM, Lee I-J: Medicinal plants and their uses in selected temperate zones of Pakistani Hindukush-Himalaya. Journal of medicinal plants research 2012, 6(24):4113-4127. 13. Khan S: In vitro antifungal activity of Rhazya stricta. Pak J Pharm Sci 2007, 20(4):274-279. 14. Ajmal S, Mohammad S, Zahid K, Bakht Z, Habib A, Alam M: Ethnomedicinal and phytoeconomic elaboration of Lilownai valley, district Shangla Pakistan. Int Res J Pharm 2012, 3:164-169. 15. Janbaz KH, Arif J, Saqib F, Imran I, Ashraf M, Zia-Ul-Haq M, Jaafar HZ, De Feo V: In-vitro and in-vivo validation of ethnopharmacological uses of methanol extract of Isodon rugosus Wall. ex Benth.(Lamiaceae). BMC complementary and alternative medicine 2014, 14(1):71. 16. Aziz MA, Khan AH, Adnan M, Izatullah I: Traditional uses of medicinal plants reported by the indigenous communities and local herbal practitioners of Bajaur Agency, Federally Administrated Tribal Areas, Pakistan. Journal of ethnopharmacology 2017, 198:268-281. 17. Zeb A, Ahmad S, Ullah F, Ayaz M, Sadiq A: Anti-nociceptive activity of ethnomedicinally important analgesic plant Isodon rugosus Wall. ex Benth: Mechanistic study and identifications of bioactive compounds. Frontiers in pharmacology 2016, 7:200. 18. Bafor EE, Uchendu AP, Osayande OE, Omoruyi O, Omogiade UG, Panama EE, Elekofehinti OO, Oragwuncha EL, Momodu A: Ascorbic Acid and Alpha-Tocopherol Contribute to the Therapy of Polycystic Ovarian Syndrome in Mouse Models. Reproductive Sciences 2020:1-19. 19. De Souza V, Zaniboni JF, Escalante-Otárola WG, Matsumoto MA, Bighetti CC, Kuga MC: Effects of the incorporation of alpha-tocopherol as antioxidant on biological and physicochemical properties of calcium hydroxide associated with bioactive vehicle. European Journal of General Dentistry 2020, 9(3):157. 20. Anburaj J, Swapna S, Amuthavalli K: Beta-Amyrin Modulates P38 MAPK and Jnk Pathway to Inhibit Cell Proliferation and Induce ROS-mediated Apoptosis in HeLa Cells. Indian Journal of Pharmaceutical Sciences 2020, 82(3):420-428. 21. Hagr T, Adam I: Phytochemical Analysis, Antibacterial and antioxidant Activities of Essential Oil from Hibiscus sabdariffa (L) Seeds,(Sudanese Karkadi). Progress in Chemical and Biochemical Research 2020:194-201. 22. Patel K, Patel DK: Health Benefits of Quassin from Quassia amara: A Comprehensive Review of their Ethnopharmacological Importance, Pharmacology, Phytochemistry and Analytical Aspects. Current Nutrition & Food Science 2020, 16(1):35-44. 23. Hashim YZH-Y, Kerr PG, Abbas P, Salleh HM: Aquilaria spp.(agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology. Journal of Ethnopharmacology 2016, 189:331-360. 24. Bansal R, Sen SS, Muthuswami R, Madhubala R: Stigmasterol as a potential biomarker for amphotericin B resistance in Leishmania donovani. Journal of Antimicrobial Chemotherapy 2020, 75(4):942-950. 25. Eboji O, Cheng W, Swanepoel B, Sowemimo A, Simelane M, Venables L, Sofidiya M, van de Venter M, Koekemoer T, Lin W: Bioactivity and characterisation of phytoconstituents from the stembark of Burkea africana Hook. Journal of Chemical Society of Nigeria 2020, 45(1). 26. Ma S, Shi C, Wang C, Guo M: Effects of ultrasound treatment on physiochemical properties and antimicrobial activities of whey protein–totarol nanoparticles. Journal of food protection 2017, 80(10):1657-1665. 27. Hou Y, Zhang X, Wang C, Guo M: Formulation and Functional Properties of Whey Protein-Based Tissue Adhesive Using Totarol as an Antimicrobial Agent. Processes 2020, 8(4):496. 28. Al-Jaber NA, Awaad AS, Moses JE: Review on some antioxidant plants growing in Arab world. Journal of Saudi Chemical Society 2011, 15(4):293-307. 29. Alves da Silva FF, Fernandes CC, Almeida de Oliveira G, Candido ACBB, Magalhaes LG, Vieira TM, Crotti AEM, Alves da Silva C: 'In vitro'antileishmanial and antioxidant activities of essential oils from different parts of'Murraya paniculata'(L.) Jack: A species of Rutaceae that occur in the'Cerrado'biome in Brazil. Australian Journal of Crop Science 2020, 14(2):347. 30. Sirois M, Lat EMR: Elsevier's Veterinary Assisting Textbook: Elsevier Health Sciences; 2016. 31. Haider F, Ullah N: Antioxidant and Antimicrobial activity of Impatiens walleriana local to Malaysia. Moroccan Journal of Chemistry, 7(3):7-3 (2019) 2548-2553. 32. Zeb A, Ullah F, Ayaz M, Ahmad S, Sadiq A: Demonstration of biological activities of extracts from Isodon rugosus Wall. Ex Benth: Separation and identification of bioactive phytoconstituents by GC-MS analysis in the ethyl acetate extract. BMC complementary and alternative medicine 2017, 17(1):284. 33. Hussain I, Khan AU, Ullah R, Alsaid MS, Salman S, Iftikhar S, Marwat GA, Sadique M, Jan S, Adnan M: Chemical Composition, Antioxidant and Anti-bacterial Potential of Essential Oil of Medicinal plant Isodon rugosus. Journal of Essential Oil Bearing Plants 2017, 20(6):1607-1613. 34. Rauf A, Muhammad N, Khan A, Uddin N, Atif M: Antibacterial and phytotoxic profile of selected Pakistani medicinal plants. World Appl Sci J 2012, 20(4):540-544. 35. Halliwell B, Gutteridge JM: Free radicals in biology and medicine: Oxford University Press, USA; 2015. 36. Babiker HA, Oudghiri-Hassani H: Comparative evaluation of total phenolic content, total flavonoids content and antioxidants activity in Skin & Pulp extracts of Cucurbita maxima. Moroccan Journal of Chemistry, 6(2):6-2 (2018) 2218-2226. 37. Sadiq A, Zeb A, Ullah F, Ahmad S, Ayaz M, Rashid U, Muhammad N: Chemical Characterization, Analgesic, Antioxidant, and Anticholinesterase Potentials of Essential Oils From Isodon rugosus Wall. ex. Benth. Frontiers in pharmacology 2018, 9. 38. Zeb A, Sadiq A, Ullah F, Ahmad S, Ayaz M: Investigations of anticholinestrase and antioxidant potentials of methanolic extract, subsequent fractions, crude saponins and flavonoids isolated from Isodon rugosus. Biological research 2014, 47(1):76. 39. Torres P, Santos JP, Chow F, dos Santos DY: A comprehensive review of traditional uses, bioactivity potential, and chemical diversity of the genus Gracilaria (Gracilariales, Rhodophyta). Algal Research 2019, 37:288-306. 40. Luqmani Y: Mechanisms of drug resistance in cancer chemotherapy. Medical Principles and Practice 2005, 14(Suppl. 1):35-48. 41. Ullah A, Uddin G, Rashid MU, Ismail I, Nasruddin N, Siddiqui BS, Ullah Z, Alamzeb M: A New Diterpene: Abietane Glycoside from the Roots of Isodon rugosus Wall Ex Benth. 42. Zeb A, Sadiq A, Ullah F, Ahmad S, Ayaz M: Phytochemical and toxicological investigations of crude methanolic extracts, subsequent fractions and crude saponins of Isodon rugosus. Biological research 2014, 47(1):57. 43. Rauf A, Khan A, Rasool S, Shah ZA, Saleem M: In-vitro antifungal activity of three selected Pakistani medicinal plants. Middle-East J Med Plants Res 2012, 1(2):41-43. 44. Walia S, Koul O: Exploring plant biodiversity for botanical insecticides. Sustainable crop protection, Biopesticide stratergies, Kalyani Publishers, New Delhi 2008:191-206. 45. Isman M: Botanical insecticides in modern agriculture and an increasingly regulated world Conference at National Center for Animal and Plant Health (CENSA). Mayabeque, Cuba 2013, 51. 46. Khan S, Taning CNT, Bonneure E, Mangelinckx S, Smagghe G, Shah MM: Insecticidal activity of plant-derived extracts against different economically important pest insects. Phytoparasitica 2017, 45(1):113-124. 47. Wood MW, Martino G, Coupal M, Lindberg M, Schroeder P, Santhakumar V, Valiquette M, Sandin J, Widzowski D, Laird J: Broad analgesic activity of a novel, selective M1 agonist. Neuropharmacology 2017, 123:233-241. 48. Shinwari ZK: Medicinal plants research in Pakistan. Journal of medicinal plants research 2010, 4(3):161-176. 49. Abbasi AM, Khan MA, Ahmad M, Zafar M: Medicinal plant biodiversity of lesser Himalayas-Pakistan: Springer Science & Business Media; 2011. 50. Sher Z, Khan Z, Hussain F: Ethnobotanical studies of some plants of Chagharzai valley, district Buner, Pakistan. Pak J Bot 2011, 43(3):1445-1452. 51. Shinwari Z, Rehman M, Watanabe T, Yoshikawa Y: Medicinal and aromatic plants of Pakistan (A Pictorial Guide). Kohat University of Science and Technology, Kohat, Pakistan 2006, 492. 52. Mushtaq B, Muhammad A, Shazia Z, Sofia S, Ajab RM: Ethnomedicinal knowledge of the most commonly used plants from Deosai Plateau, Western Himalayas, Gilgit Baltistan, Pakistan. Journal of ethnopharmacology 2014. 53. Amjad MS, Arshad M, Saboor A, Page S, Chaudhari SK: Ethnobotanical profiling of the medicinal flora of Kotli, Azad Jammu and Kashmir, Pakistan: Empirical reflections on multinomial logit specifications. Asian Pacific journal of tropical medicine 2017, 10(5):503-514. 54. Kumar K, Sharma YP, Manhas R, Bhatia H: Ethnomedicinal plants of Shankaracharya Hill, Srinagar, J&K, India. Journal of ethnopharmacology 2015, 170:255-274. 55. Jeelani SM, Wani MP, Kumari S, Siddique MAA: Ethnobotany of some polypetalous plants from the Kashmir Himalaya. Journal of Medicinal Plants Research 2013, 7(36):2714-2721.

Downloads

Published

31-12-2020

How to Cite

1.
Muhammad Muneeb Ahmad. Isodon rugosus as potential source of phytopharmacological agents: A review. ijp [Internet]. 2020 Dec. 31 [cited 2024 Dec. 3];12(4):79-85. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/640

Issue

Section

Review Article