Phytochemical Screening and Antimicrobial Activity of the Leaf Extract of Mirabilis jalapa Against Pathogenic Microorganisms

Authors

  • V. Kiran Kumar Microbiology laboratory, Apex Biosciences, Himayathnagar, Hyderabad – 500029
  • N. Ravi Sankar Microbiology laboratory, Apex Biosciences, Himayathnagar, Hyderabad – 500029
  • S. Ramya Directorate of Sorghum Research, Rajendranagar, Hyderabad – 500030
  • R.V. Sahaja Microbiology laboratory, Apex Biosciences, Himayathnagar, Hyderabad – 500029
  • K. Saritha Department of Biochemistry, University of Hyderabad, Hyderabad – 500046
  • K. Govinda Reddy Microbiology laboratory, Apex Biosciences, Himayathnagar, Hyderabad – 500029
  • N. V. Naidu Global Institute of Biotechnology, Himayathnagar, Hyderabad – 500029

Keywords:

Mirabilis jalapa, leaf extract, phytochemicals, antimicrobial activity

Abstract

Investigation of the phytochemical constituents and antimicrobial activity of the leaf extracts of Mirabilis jalapa were carried out using acetone, chloroform, ethanol and methanol. These extracts were subjected to screening of preliminary phytochemical tests. Phytochemical analysis showed the presence of alkaloids, flavanoids, phenols, glycosides, tannins, saponins and lignins. The methanol extract exhibited the largest zone of inhibition (21mm in dia with 500µg/disc extract) against Staphylococcus aureus and the highest inhibition of fungal radial mycelial growth (97.5% with 500µg/ml medium) against Aspergillus flavus. The methanol extract exhibited the lowest MIC against Staphylococcus aureus (39 µg/ml) and Aspergillus flavus (45µg/ml). It appeared that M. jalapa could be a potential natural source of new antimicrobial agent.

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Published

31-12-2010

How to Cite

1.
V. Kiran Kumar, N. Ravi Sankar, S. Ramya, R.V. Sahaja, K. Saritha, K. Govinda Reddy, N. V. Naidu. Phytochemical Screening and Antimicrobial Activity of the Leaf Extract of Mirabilis jalapa Against Pathogenic Microorganisms. ijp [Internet]. 2010 Dec. 31 [cited 2024 Nov. 23];2(4):402-7. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/64

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Original Research Articles