Gastro protective activity of Momordica cymbalaria fruits against experimentally induced gastric ulcer in rats

Authors

  • P. Bharathi Dhasan Professor & Head of the Dept., Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Tamilnadu, 626190 India.
  • M. Jagadeesan Professor & Head of the Dept., Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Tamilnadu, 626190 India

Keywords:

Momordica cymbalaria, anti-ulcer, anti-secretory, gastro protective

Abstract

The effect of petroleum ether, chloroform and methanol extracts of unripe fruits of Momordica cymbalaria (Cucurbitaceae) was investigated in rats to evaluate the anti-ulcer activity by using three models, i.e. aspirin, alcohol and pyloric ligation induced gastric ulcer in rats. The parameters taken for assessing the anti-ulcer activity were volume of gastric secretion, PH, free acidity, total acidity and ulcer index. The results of the study revealed that the methanol extract of Momordica cymbalaria fruits had significantly (P < 0.001) reduced the volume of gastric acid secretion, PH, free acidity, total acidity and ulcer index with respect to control.

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Published

31-12-2010

How to Cite

1.
P. Bharathi Dhasan, M. Jagadeesan. Gastro protective activity of Momordica cymbalaria fruits against experimentally induced gastric ulcer in rats. ijp [Internet]. 2010 Dec. 31 [cited 2024 Dec. 6];2(4):385-1. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/62

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Original Research Articles