Glinus oppositifolius (L.) Aug. DC.: A Repository of Medicinal Potentiality

Authors

  • Tania Chakraborty Laboratory of Cell and Molecular Biology, Department of Botany, 35, Ballygunge Circular Road, Kolkata-700019, India.
  • Santanu Paul Department of Botany; Center of Advanced Study; University of Calcutta Kolkata 700019 INDIA

Keywords:

Glinus oppositifolius, pharmacological use, bio-active compounds

Abstract

Plants have been used in the treatment of human diseases since centuries. Due to their medicinal values, more than 80% of the modern world population still rely on plants as their primary source of medicines. Traditional plant-based medicines are widespread in Asian countries like the Indian subcontinent, Bangladesh, China, Japan, Pakistan, Indonesia, Myanmar, and in the continent of Africa. Nowadays, plant-derived medicines are gaining wider acceptance even in developed countries of the Western world. More than 50% of all drugs currently in clinical use are of natural origin. Plants are therefore emerging as a novel source for drugs and opening up new vistas in drug therapy research. A bird’s eye view of the therapeutic potential of the angiospermic plant Glinus oppositifolius (L.) Aug. DC. (Family: Molluginaceae) has been presented in this review, along with the ethnobotanical uses and scientific evidences presented in support of the traditional claims. Several pharmacologically active chemical compounds have been reported from the plant in recent years and the biological roles of those chemical compounds have been summarized. The anti-cancer effects shown by some of those phyto-constituents have also been elucidated. The novel chemical constituents reported from this plant may evoke further research on the plausible medicinal effects and the bio-safety standards of Glinus oppositifolius.

References

Davies G. Time Tables of Medicine. Black Dog & Leventhal, New York.2000.

Wang H, Khor TO, Shu L, Su ZY, Fuentes F, Lee JH, Kong ANT. Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability. Anticancer Agents Med Chem. 2012;12: 1281–1305.

Raskin I, Ripoll C. Can an apple a day keep the doctor away? Curr. Pharm. Des.2004;10:3419–3429.

Sheldon JW, Balick MJ, Laird SA. Medicinal plants: can utilization and conservation coexist? Adv. Econ. Bot.1997;12.

Ishii R, Yoshikawa K, Minakata H, Komura H, Kada T. Specificities of Bio-antimutagens in Plant Kingdom. Agricultural and Biological Chemistry.1984;48: 2587–2591.

Hoyos LS, Au WW, Heo MY, Morris DL, Legator MS. Evaluation of the genotoxic effects of a folk medicine, Petiveria alliacea (Anamu). Mutat. Res.1992;280:29–34.

Burkhill HM. The Useful Plants of West Tropical Africa, 1, second ed., Royal Botanical Gardens, Kew.1985.

Debes SC. Enmedisinplantefra Mali, Glinus oppositifolius, [Master’s Thesis], School of Pharmacy, University of Oslo, Norway.1998.

Diallo D, Hveem B, Mahmoud MA, Berge G, Paulsen BS, Maiga A. An Ethnobotanical Survey of Herbal Drugs of Gourma District, Mali. Pharmaceutical Biology. 1999;37:80–91.

Inngjerdingen KT, Debes SC, Inngjerdingen M, Hokputsa S, Harding SE, Rolstad B, Michaelsen TE, Diallo D, Paulsen BS. Bioactive pectic polysaccharides from Glinus oppositifolius (L.) Aug. DC., a Malian medicinal plant, isolation and partial characterization. J Ethnopharmacol. 2005;101:204–214.

Inngjerdingen KT, Kiyohara H, Matsumoto T, Petersen D, Michaelsen TE, Diallo D, Inngjerdingen M, Yamada H, Paulsen BS. An immunomodulating pectic polymer from Glinus oppositifolius. Phytochemistry. 2007;68:1046–1058.

Inngjerdingen KT, Patel TR, Chen X, Kenne L, Allen S, Morris GA, Harding SE, Matsumoto T, Diallo D, Yamada H, Michaelsen TE, Inngjerdingen M, Paulsen BS. Immunological and structural properties of a pectic polymer from Glinus oppositifolius. Glycobiology. 2007;17:1299–1310.

Sheu SY, Yao CH, Lei YC, Kuo TF. Recent progress in Glinus oppositifolius research. Pharm Biol. 2014;52:1079–1084.

Diallo D. Ethnopharmacological survey of medicinal plants in Mali and phytochemical study of four of them: Glinus oppositifolius (Aizoaceae), Diospyros abyssinica (Ebenaceae), Entadaafricana (Mimosaceae), Trichilia emetic (Meliaceae), These de Doctorat. Faculte des Sciences, Universite de Lausanne, Switzerland. 2000.

Traore F, Faure R, Ollivier E, Gasquet M, Azas N, Debrauwer L, Keita A, Timon-David P, Balansard G. Structure and antiprotozoal activity of triterpenoid saponins from Glinus oppositifolius. Planta Med. 2000;66:368–371.

Diallo D, Marston A, Terreaux C, Touré Y, Paulsen BS, Hostettmann K. Screening of Malian medicinal plants for antifungal, larvicidal, molluscicidal, antioxidant and radical scavenging activities. Phytother. Res. 2001;15:401–406.

Asok Kumar K, UmaMaheswari M, Sivashanmugam AT, Subhadra Devi V, Subhashini N, Ravi TK. Free radical scavenging and antioxidant activities of Glinus oppositifolius (carpet weed) using different in vitro assay systems. Pharmaceutical Biology. 2009;47:474–482.

Natarajan P, Thirupathi AT, Sekharan TR, Sundar AS, Arivukkarasu R, Ganesan M. Hepatoprotective effect of Glinus oppositifolius Linn. Research Journal of Pharmacology and Pharmacodynamics. 2010;2:289–292.

Kumar S, Pathania AS, Saxena AK, Vishwakarma RA, Ali A, Bhushan S. The anticancer potential of flavonoids isolated from the stem bark of Erythrina suberosa through induction of apoptosis and inhibition of STAT signaling pathway in human leukemia HL-60 cells. Chem. Biol. Interact. 2013;205:128–137.

Behera GM, Satish Kumar BN, Malay Baidya M, Panigrahi G. Antihyperglycemic, antihyperlipidemic and antioxidant activity of Glinus oppositifolius (L.) Aug. DC. DC. Pharmacologyonline. 2010;3:915–36.

Sahu SK, Das D, Tripathy NK. Evaluation of hypoglycemic activity of Mollugo pentaphylla and Glinus oppositifolius (L). Rasayan J Chem. 2012;5:57–62.

Panigrahi G, Mishra US, Mahapatra S. Hypoglycemic and hypolipidemic activities of methanol extract of Glinus oppositifolius. Int J Pharm. 2012;2:491–497.

Pattanayak S, Nayak SS, Dinda SC, Panda D, Kolhe DM. Antimicrobial and anthelmintic potential of Glinus oppositifolius (Linn.) family: Molluginaceae. Pharmacologyonline. 2011;1:165–9.

Jagtap SD, Deokule SS, Bhosle SV. Some unique ethnomedicinal uses of plants used by the Korku tribe of Amravati district of Maharashtra. India Journal of Ethnopharmacology. 2006;107:463–469

Sekharan R, Jagadeesan M. An ethnobotanical survey of Javvadhu hills, Tamil Nadu. Ancient Science of Life. 1997;16:206-214

Chowdhury M, Das AP. Inventory of some ethno-medicinal plants in wetland areas of Maldah district of West Bengal. Pleione. 2009;3(1):83-88.

Setiya AV, Narkhede SD, Dongarwar NM. Exploration and documentation of some wild edible plants used by the aboriginals from Gadchiroli District (MS) India. IARJSET. 2016;3.

Pattanayak S, Mandal TK, Bandyopadhyay SK. Ethnomedicinal study of plants used for protection and stimulation of liver in Southern West Bengal, India. Exploratory Animal and Medical Research. 2016;6:164–178.

Sahakitpichan P, Disadee W, Ruchirawat S, Kanchanapoom T. L-(-)-(N-trans-cinnamoyl) arginine, an acylamino acid from Glinus oppositifolius (L.) Aug. DC. Molecules. 2010;15:6186–6192.

Hoque N, Habib MR, Imam MZ, Ahmed J, Rana MS. Analgesic and anti-inflammatory potential of methanolic extract of Glinus oppositifolius L. Aust J Basic & Appl. Sci. 2011;5:729-733.

Hoque N, Imam MZ, Akter S, Mazumder M, Hoque E, Hasan SM, Ahmed J, Rana M. Antioxidant and antihyperglycemic activities of methanolic extract of Glinus oppositifolius leaves. 2011;01:50-53.

Rahmatullah M, Haque MR, Islam SK, Jamal F, Bashar ABMA, Ahmed R, Ahmed I, Jahan R, Ahsan S, Chowdhury MH. A survey on the use of medicinal plants by folk medicinal practitioners in three areas of Pirojpur District, Bangladesh. American-Eurasian Journal of Sustainable Agriculture. 2010;4:247–259.

Mollik MAH, Hossan MS, Paul AK, Taufiq-Ur-Rahman M, Jahan R, Rahmatullah M. A Comparative Analysis of Medicinal Plants Used by Folk Medicinal Healers in Three Districts of Bangladesh and Inquiry as to Mode of Selection of Medicinal Plants. Ethnobotany Research and Applications. 2010;8:195–218.

Bhowmik R, Saha MR, Rahman MA, Islam MAU. Ethnomedicinal Survey of Plants in the Southern District Noakhali, Bangladesh. Bangladesh Pharmaceutical Journal. 2015;17:205–214.

Ragasa CY, Cabrera EC, Torres OB, Buluran AI, Espineli DL, Raga DD, Shen CC. Chemical constituents and bioactivities of Glinus oppositifolius. Pharmacognosy Research. 2015;7:138.

Chen YH. Studies on the chemical constituents from Glinus oppositifolius (L.) Aug. DC [Master’s thesis], China Medical University, Taichung City, Taiwan. 2011.

Ragasa CY, Espineli DL, Mandia EH, Don MJ, Shen CC. A new triterpene from Glinus oppositifolius. Chinese journal of natural medicines. 2012;10:284–286.

Ullah MO, Haque M, Urmi KF, Zulfiker AHM, Anita ES, Begum M, Hamid K. Anti-bacterial activity and brine shrimp lethality bioassay of methanolic extracts of fourteen different edible vegetables from Bangladesh. Asian Pac J Trop Biomed. 2013;3:1–7.

Islam MT, Khan MAA, Hossain JA, Barua J. Antioxidant, antimicrobial and cytotoxic bioassay of Mollugo oppositifolius L. International Journal of Green Pharmacy (IJGP). 2011;5:141-144.

Martin-Puzon JJR, Valle DL, Rivera WL. TLC profiles and antibacterial activity of Glinus oppositifolius L. Aug. DC. (Molluginaceae) leaf and stem extracts against bacterial pathogens. Asian Pacific Journal of Tropical Disease. 2015;5:569–574.

Adenusi AA, Odaibo AB. Laboratory assessment of molluscicidal activity of crude aqueous and ethanolic extracts of Dalbergia sissoo plant parts against Biomphalaria pfeifferi. Travel Med Infect Dis. 2008;6:219–227.

Sahu SK, Das D, Tripathy NK. Hepatoprotective activity of aerial part of Glinus oppositifolius L. against Paracetamol-induced Hepatic Injury in Rats. Asian Journal of Pharmacy and Technology. 2012;2:154–156.

Pattanayak S, Nayak SS, Dinda SC, Panda D. Preliminary anti-diarrhoeal activity of aerial parts of Glinus oppositifolius (L.) in rodents. Recent Advances in Pharmaceutical Science Research. 2012;1:50-57.

Moniruzzaman M, Sharoti Bhattacharjee P, Rahman Pretty M, Sarwar Hossain M. Sedative and Anxiolytic-Like Actions of Ethanol Extract of Leaves of Glinus oppositifolius (Linn.) Aug. DC. Evidence-Based Complementary and Alternative Medicine.2016.

Vasincu A, Miron A, Bild V. Preliminary research concerning antinociceptive and anti-inflammatory effects of two extracts from Glinus oppositifolius (L.) Aug. DC. Rev Med ChirSoc Med Nat Iasi. 2014;118:866–872.

Pattanayak S, Padmalatha K. Anti Diabetic Activity of aerial parts of Glinus opposi-tifolius L, against glucose overloaded and streptozoto-cin-induced Diabetes in Albino Rats. Int J. Nat. Prod Mar Bio.2015;1:29-34.

Seidel C, Schnekenburger M, Mazumder A, Teiten MH, Kirsch G, Dicato M, Diederich M. 4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer. Biochem. Pharmacol. 2016;99:31–52.

Fong Y, Tang CC, Hu HT, Fang HY, Chen BH, Wu CY, Yuan SS, Wang HMD, YC. Chen, Teng YN, Fong CCC. Inhibitory effect of trans-ferulic acid on proliferation and migration of human lung cancer cells accompanied with increased endogenous reactive oxygen species and β-catenin instability. Chin Med. 2016;11:45–45.

Janicke B, Hegardt C, Krogh M, Onning G, Akesson B, Cirenajwis HM, Oredsson SM. The antiproliferative effect of dietary fiber phenolic compounds ferulic acid and p-coumaric acid on the cell cycle of Caco-2 cells. Nutr Cancer. 2011;63:611–622.

Jayaprakasam B, Vanisree M, Zhang Y, Dewitt DL, Nair MG. Impact of alkyl esters of caffeic and ferulic acids on tumor cell proliferation, cyclooxygenase enzyme, and lipid peroxidation. J. Agric. Food Chem. 2006;54:5375–5381.

Karthikeyan S, Kanimozhi G, Prasad NR, Mahalakshmi R. Radiosensitizing effect of ferulic acid on human cervical carcinoma cells in vitro. Toxicol In Vitro. 2011;25:1366–1375.

Akagi K, Hirose M, Hoshiya T, Mizoguchi Y, Ito N, Shirai T. Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model. Cancer Lett. 1995;94:113–121.

De Stefani E, Boffetta P, Ronco AL, Brennan P, Deneo-Pellegrini H, Carzoglio JC, Mendilaharsu M. Plant sterols and risk of stomach cancer: a case-control study in Uruguay. Nutr Cancer. 2000;37:140–144.

Jeon GC, Park MS, Yoon DY, Shin CH, Sin HS, Um SJ. Antitumor activity of spinasterol isolated from Pueraria roots. Exp. Mol. Med. 2005;37:111–120.

Villaseñor IM, Domingo AP. Anticarcinogenicity potential of spinasterol isolated from squash flowers. Teratog, Carcinog. Mutagen. 2000;20:99–105.

Awad AB, Barta SL, Fink CS, Bradford PG. beta-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism. MolNutr Food Res. 2008;52:419–426.

Park C, Moon DO, Rhu CH, Choi BT, Lee WH, Kim GY, Choi YH. Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio. Biol. Pharm. Bull. 2007;30:1317–1323.

Zhao Y, Chang SKC, Qu G, Li T, Cui H. Beta-sitosterol inhibits cell growth and induces apoptosis in SGC-7901 human stomach cancer cells. J. Agric. Food Chem. 2009;57:5211–5218.

Awad AB, Burr AT, Fink CS. Effect of resveratrol and beta-sitosterol in combination on reactive oxygen species and prostaglandin release by PC-3 cells. Prostaglandins Leukot. Essent. Fatty Acids. 2005;72:219–226.

Choi YH, Kong KR, Kim YA, Jung KO, Kil JH, Rhee SH, Park KY. Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells. Int. J. Oncol. 2003;23:1657–1662.

Awad AB, von Holtz RL, Cone JP, Fink CS, Chen YC. Beta-Sitosterol inhibits growth of HT 29 human colon cancer cells by activating the sphingomyelin cycle. Anticancer Res. 1998;18:471–473.

Baskar AA, Ignacimuthu S, Paulraj GM, Al Numair KS. Chemopreventive potential of beta Sitosterol in experimental colon cancer model--an in vitro and In vivo study. BMC Complement Altern Med. 2010;10:24.

Awad AB, Chen YC, Fink CS, Hennessey T. beta-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids. Anticancer Res. 1996;16:2797–2804.

Wu C, Chen F, Rushing JW, Wang X, Kim HJ, Huang G, Haley-Zitlin V, He G. Antiproliferative activities of parthenolide and golden feverfew extract against three human cancer cell lines. J Med Food. 2006;9:55–61.

Park C, Moon D, Ryu C, Choi B, Lee W, Kim G, Choi Y. Beta-sitosterol sensitizes MDA-MB-231 cells to TRAIL-induced apoptosis. Acta. Pharmacol. Sin. 2008;29:341–348.

Vundru SS, Kale RK, Singh RP. β-Sitosterol induces G1 arrest and causes depolarization of mitochondrial membrane potential in breast carcinoma MDA-MB-231 cells. BMC Complement Altern Med. 2013;13:280.

Awad AB, Chinnam M, Fink CS, Bradford PG. beta-Sitosterol activates Fas signaling in human breast cancer cells. Phytomedicine. 2007;14:747–754.

Awad AB, Roy R, Fink CS. Beta-sitosterol, a plant sterol, induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells. Oncol. Rep. 2003;10:497–500.

Zhou Y, Liu YE, Cao J, Zeng G, Shen C, Li Y, Zhou M, Chen Y, Pu W, Potters L, Shi YE. Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clin. Cancer Res. 2009;15:5161–5169.

Nagaprashantha LD, Vatsyayan R, Singhal J, Fast S, Roby R, Awasthi S, Singhal SS. Anticancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer. Biochem. Pharmacol. 2011;82:1100–1109.

Kim SH, Hwang KA, Choi KC. Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models. J. Nutr. Biochem. 2016;28:70–82.

Zhang Q, Wang D, Zhang M, Zhao Y, Yu Z. Studies on New Activities of Enantiomers of 2-(2 Hydroxypropanamido) Benzoic Acid: Antiplatelet Aggregation and Antithrombosis. PLOS ONE. 2017;12:0170334.

Das U, Manna K, Sinha M, Datta S, Das DK, Chakraborty A, Ghosh M, Saha KD, Dey S. Role of ferulic acid in the amelioration of ionizing radiation induced inflammation: a murine model. PLoS ONE. 2014;9:97599.

Manikandan R, Beulaja M, Thiagarajan R, Pandi M, Arulvasu C, Prabhu NM, Saravanan R, Esakkirajan M, Palanisamy S, Dhanasekaran G, Nisha RG, Devi K, Latha M. Ameliorative effect of ferulic acid against renal injuries mediated by nuclear factor-kappaB during glycerol-induced nephrotoxicity in Wistar rats. Ren Fail. 2014;36:154–165.

Panneerselvam L, Subbiah K, Arumugam A, Senapathy JG. Ferulic acid modulates fluoride induced oxidative hepatotoxicity in male Wistar rats. Biol Trace Elem Res. 2013;151:85–91.

Yuan X, Wang J, Yao H. Antioxidant activity of feruloylated oligosaccharides from wheat bran. Food Chemistry. 2005;90:759–764.

Roy S, Metya SK, Sannigrahi S, Rahaman N, Ahmed F. Treatment with ferulic acid to rats with streptozotocin-induced diabetes: effects on oxidative stress, pro-inflammatory cytokines, and apoptosis in the pancreatic β cell. Endocrine. 2013;44:369–379.

Ramar M, Manikandan B, Raman T, Priyadarsini A, Palanisamy S, Velayudam M, Munusamy A, MarimuthuPrabhu N, Vaseeharan B. Protective effect of ferulic acid and resveratrol against alloxan-induced diabetes in mice. Eur. J. Pharmacol. 2012;690:226–235.

Stagos D, Kazantzoglou G, Magiatis P, Mitaku S, Anagnostopoulos K, Kouretas D. Effects of plant phenolics and grape extracts from Greek varieties of Vitis vinifera on Mitomycin C and topoisomerase I-induced nicking of DNA. Int. J. Mol. Med. 2005;15:1013–1022.

Tanaka T, Kojima T, Kawamori T, Wang A, Suzui M, Okamoto K, Mori H. Inhibition of 4 nitroquinoline-1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids. Carcinogenesis. 1993;14:1321–1325.

Tamai K, Tezuka H, Kuroda Y. Different modifications by vanillin in cytotoxicity and genetic changes induced by EMS and H2O2 in cultured Chinese hamster cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis.1992;268:231–237.

Gade S, Rajamanikyam M, Vadlapudi V, Nukala KM, Aluvala R, Giddigari C, Karanam NJ, Barua NC, Pandey R, Upadhyayula VSV, Sripadi P, Amanchy R, Upadhyayula SM. Acetylcholinesterase inhibitory activity of stigmasterol & hexacosanol is responsible for larvicidal and repellent properties of Chromolaena odorata. Biochim. Biophys. Acta. 2017;1861:541–550.

Wilt T, Ishani A, MacDonald R, Stark G, Mulrow C, Lau J. Beta-sitosterols for benign prostatic hyperplasia. Cochrane Database Syst Rev. CD001043.2000.

Wilt TJ, MacDonald R, Ishani A. beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int. 1999;83:976–983.

Berges RR, Kassen A, Senge T. Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up. BJU Int. 2000;85:842–846.

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31-12-2017

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Tania Chakraborty, Santanu Paul. Glinus oppositifolius (L.) Aug. DC.: A Repository of Medicinal Potentiality. ijp [Internet]. 2017 Dec. 31 [cited 2024 Nov. 21];9(4):543-57. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/567

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