Gmelina arborea: chemical constituents, pharmacological activities and applications
Gmelina arborea (G. arborea) is a bio-prospective plant belonging to family verbenaceae. It is widely used for it’s medicinal properties from ancient times. The present paper comprehensively reviewed the traditional uses, medicinal properties and chemical constituents isolated from G. arborea based on literature reported as well as critical analysis of the research. The present article is aimed to provide information on recent advances and new foundations and direction for further exploring G. arborea for its applications. Pharmacological research reviewed that G. arborea possess various medicinal properties and biological activities including antidiuretic, antidiarrhoeal, antipyretic, antianalgesic, antioxidant, antidiabetic, antihelmintic, antibacterial, antifungal, cardiopotective, insecticidal, antiulcer, gastro-protective, anticancer, antihyperlipidemic and immunomodulatory activity. It has been reported for its applications in treatment of bone fracture, hypertension and regeneration of β-cells. The main chemical constituents of G. arborea include lignans, iridoid glycoside, flavonoids, flavons, flavone glycoside and sterols. The present review provides all the references and beneficial directions to explore further application of G. arborea.
. Wang Z. Cultivation and utilization of
Gmelina arborea in South Yunnan,
China, New Forest, Netherlands. 2004;
. Banu M, Gururaja GM, Deepak M,
Roopashree T, Shashidhara S. An
overview on Phytochemistry and
Pharmacological properties of Gmelina
arborea. J Nat Prod Plant Resour.
; 3; 62.
. Lauridsen EB, Kjaer ED. Provenance
research in Gmelina arborea Linn.
Roxb. A summary of results from three
decades of research and a discussion
of how to use them, International For
Rev. 2002; 4: 1.
. Evans J. Plantation forestry in the
tropics Clarendon press, Oxford, UK.
. Jensen M. Trees commonly cultivated
in Southeast Asia, Illustrated field
guide. 38, FAO, Bangkok, Thailand.
. Davidson J. Assistance to the forestry
sector of Bangladesh. Species and
sites-What to plant and where to plant.
Field Doc. No. 5,
UNDP/FAO/BGD/79/017. 1985; 50.
. Padua JM. Juvenile selection of
Gmelina arborea clones in the
Philippines, New Forest 2004; 28:195.
. Dvorak WS, World view of Gmelina
arborea: opportunities and challenges
New Forests New Forest. 2004; 28:
. Roquel RM, TomazelloFo M. Wood
density and fiber dimensions of
Gmelina arborea in fast growth trees in
Costa Rica: relation to the growth rate.
Investigación Agraria: Sistemas y
Recursos Forestales. 2007; 16: 267.
. El-Mahmood AM, Doughari JH, Kiman
HS, In vitro antimicrobial activity of
crude leaf and stem bark extracts of
Gmelina arborea (Roxb) against some
pathogenic species of
Enterobacteriaceae. Afr J Pharm
Pharmacol.,2010; 4: 355.
. Valsaraja R, Pushpangadana P, Smitt
UW, Adsersenb A, Nymanb U.
Antimicrobial screening of selected
medicinal plants from India. J
Ethnopharmacol. 1997; 58: 75.
. Idu M, Ovuakporie-Uvo PO, Ndana
RW. Preliminary Phytochemistry and In
Vitro Antimicrobial Properties of The
Chloroform and Ethanol Extracts of
The Roots of Cedrela Odorata,
Chlorophora Excelsa and Gmelina
Arborea. International journal of
Analytical, Pharmaceutical and
Biomedical Science (IJAPBS). 2015; 4:
. Kawamura F, Ohara S, Nishida A.
Antifungal activity of constituents from
the heartwood Gmelina arborea: part 1.
Sensitive antifungal assay against
Basidiomycetes, Holzforschung. 2004;