Curative effect of Plumbago indica root extract on thioacetamide induced hepatotoxicity in experimental rats

Authors

  • Eldhose Binil 1) School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala-686560, India 2) Department of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington DC 20057, USA India
  • Kuriakose Jayesh School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala-686560, India
  • Latha Mukalel Sankunni School of Biosciences, Mahatma Gandhi University, Kottayam, Kerala-686560, India

Keywords:

Plumbago indica, antioxidant, hepatotoxicity, curative effect, oxidative stress, thioacetamide

Abstract

The root parts of Plumbago indica is widely used in the Indian Ayurvedic traditional system. The study was designed to evaluate the hepato curative activity Plumbago Indica (PLBM) methanolic root extracts at different doses (100 and 200 mg/kg bw) against thioacetamide induced liver damage in albino wistar rats. Liver damage was induced by administration of Thioacetamide (100 mg/kg bw) and was assessed by evaluating the activity of liver-function marker enzymes, antioxidant enzymes and lipid peroxidation. The liver sections were evaluated for histopathological changes. PLBM significantly (p ≤ 0.05) reversed the elevation of serum liver enzymes and hepatic levels of antioxidant markers. Histopathological findings also confirmed the curative effect of Plumbago Indica in a dose dependent manner. Thus this study scientifically rationale the use of Plumbago indica root as a promising drug against various liver disorders.

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Published

31-03-2017

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Eldhose Binil, Kuriakose Jayesh, Latha Mukalel Sankunni. Curative effect of Plumbago indica root extract on thioacetamide induced hepatotoxicity in experimental rats. ijp [Internet]. 2017 Mar. 31 [cited 2024 Oct. 8];9(1):138-43. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/522

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