Evaluation of central nervous system depressant activity of methanolic and petroleum ether extract of Manilkara zapota leaves (in vivo)

Authors

  • Manirujjaman Southeast University, Bangladesh .
  • Trudi Collet Queensland University of Technology. Australia

Keywords:

CNS depressant, hole cross open field, Manilkara zapota leaves

Abstract

The purpose of this study was to examine the central nervous system (CNS) -depressant activity of methanolic and petroleum ether extracts of leaves obtained from Manilkara zapota (Sapotaceae) in vivo. CNS-depressant action was evaluated by observing the effects of plant extracts on both exploratory and spontaneous locomotor activity in mice using open field and hole cross tests respectively. The extracts were found to exhibit CNS-depressant activity in a dose-dependent manner. In the open field test, both the methanolic and petroleum ether extracts reduced the exploratory behavior of mice significantly (p<0.05). Although the extracts reduced locomotor activity in the hole cross test, the results were found to be insignificant. Overall, these findings indicate that both types of extracts derived from M. zapota leaves possess CNS-depressant activity.

References

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Published

30-09-2016

How to Cite

1.
Manirujjaman, Trudi Collet. Evaluation of central nervous system depressant activity of methanolic and petroleum ether extract of Manilkara zapota leaves (in vivo). ijp [Internet]. 2016 Sep. 30 [cited 2024 Oct. 22];8(3):308-11. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/472

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Original Research Articles