Phytochemical Screening and Analgesic Activity of Opuntia ficus indica cladods extract in Wistar rats

Authors

  • Sihem HALMI Laboratory of Pharmacology and Toxicology, Institute of Veterinary Sciences, University of Mentouri Constantine1, Algeria.
  • Madi A Laboratory of Pharmacology and Toxicology, Institute of Veterinary Sciences, University of Mentouri Constantine1, Algeria.
  • Madi A Laboratory of Pharmacology and Toxicology, Institute of Veterinary Sciences, University of Mentouri Constantine1, Algeria.
  • Berouel K Laboratory of Pharmacology and Toxicology, Institute of Veterinary Sciences, University of Mentouri Constantine1, Algeria.
  • Lemoui R Research Unity : Valorization of natural resources, Bioactive Molecules and Physico-Chemical and Bilogical Analysis. University of Mentouri Constantine 1, Algeria.
  • Benlakssira B Laboratory of Pharmacology and Toxicology, Institute of Veterinary Sciences, University of Mentouri Constantine1, Algeria.
  • Hamdi pacha Y Laboratory of Pharmacology and Toxicology, Institute of Veterinary Sciences, University of Mentouri Constantine1, Algeria.

Keywords:

Extract, Phytochemical, Pain, Analgesic, Opuntia ficus indica

Abstract

The purpose of this work is the study of the peripheral and central analgesic activity of the Opuntia ficus indica cladods extract. Different concentrations are tested: 1000 mg/kg; 2000 mg/kg and 3000 mg/kg of body weight on rats by three different methods: the tail flick, the hot-plate and the writhing test to the acetic acid. The results obtained show that the aqueous extract of the cladods has an peripheral and central analgesic activity comparable to that of the Aspirin after administration to rats. The phytochemical analysis of the extract reveals the presence of tannins, coumarins, flavonoids, steroids and anthocyanins whose properties can be used to advantage in the treatment of pain. Our results confirm the traditional use of Opuntia ficus-indica cladods as an analgesic.

References

Gaucher-Hamoudi O. et Guiose M.

Soins palliatifs et psychomotricité.

Heures de France, 2007.

Babulka P. « Plantes médicinales du

traitement des pathologies

rhumatismales: de la médecine

traditionnelle à la phytothérapie

moderne », Phytothérapie, vol. 5, no

, 2007. 137–145,

Alencar SM, Oldoni TLC, Castro ML,

Cabral ISR, Costa-Neto C M, Cury JA,

Rosalen PL. et M. Ikegaki, « Chemical

composition and biological activity of a

new type of Brazilian propolis: red

propolis », J. Ethnopharmacol., vol.

, no 2, , 2007. 278–283.

Halmi S, Benlakssira B, Bechtarzi K,

Djerrou Z, Djeaalab H, Riachi F,

Pacha YH. et others,

« Antihyperglycemic activity of prickly

pear (Opuntia ficus-indica) aqueous

extract. », Int. J. Med. Aromat. Plants,

vol. 2, no 3, , 2012 540–543.

Halmi S, Benlaksira B, Bechtarz K,

Berouel K, Serakta M, Riachi F,

Djaalab H, Maameri Z, Djerrou Z,

PACHA YH. et others, « Pharmacotoxicological study of Opuntia ficus

indica L. aqueous extract in

experimental animals », Int. J. Med.

Aromat. Plants, vol. 3, no 3, , 2013

–381.

Sanogo R, Diallo D, Diarra S,

Ekoumou C, et Bougoudogo D.

« Activité antibactérienne et

antalgique de deux recettes

traditionnelles utilisées dans le

traitement des infections urinaires et

la cystite au Mali », Mali Méd., vol. 21,

no 1, , 2006 18–24.

Dohou N, Yamni K, Gmira N, et Idrissi

Hassani LM. « Étude de polyphénols

des feuilles d’une endémique ibéro

marocaine, Thymelaea lythroides »,

Acta Botánica Malacit., vol. 29, , 2004

–239.

N’Guessan K, Kadja B, Zirihi , Traoré

D, et Aké-Assi L. « Screening

phytochimique de quelques plantes

médicinales ivoiriennes utilisées en

pays Krobou (Agboville, Côted’Ivoire) », Sci. Nat., vol. 6, no 1 .2009

Yamini K. « Pharmacognostical and

Preliminary Phytochemical Screening

on Leaves of Trianthema decandra

Linn. », Int. J. Pharm. Biol. Arch., vol.

, no 3, 2011.

Sy G Y, Fall A D, Diatta W, Gueye M,

Badji K, Bassène E, Faye B. et others,

« Analgesic and anti-inflammatory

activity of aqueous root extract of

Cassia sieberiana DC

(Caesalpiniaceae) », Afr J Pharm

Pharmacol, vol. 3, 2009. 651–653,.

Vaz Z R, Yunes RA, Calixto JB. et

others, « Antinociceptive action of 2-

(4-bromobenzoyl)-3-methyl-4, 6-

dimethoxy benzofuran, a novel

xanthoxyline derivative on chemical

and thermal models of nociception in

mice. », J. Pharmacol. Exp. Ther., vol.

, no 1, 1996 304–312.

Le Bars D, Gozariu M, et Cadden S

W. « Évaluation de la douleur aiguë

chez l’animal d’expérience. Première

partie », in Annales francaises

d’anesthesie et de reanimation, 2001,

vol. 20, p. 347–365.

Al-Sobarry M, Alwashli A, Cherrah Y,

et Alaoui K. « Toxicité aiguë et action

analgésique d’extrait éthanolique des

feuilles d’Aloe perryi, plante

endémique du Yémen »,

Phytothérapie, vol. 11, no 1, 2013 17–

Elisabetsky E, Amador T A,

Albuquerque R. R., Nunes D. S., et do

CT Carvalho A. « Analgesic activity of

Psychotria colorata (Willd. ex R. & S.)

Muell. Arg. alkaloids », J.

Ethnopharmacol., vol. 48, no 2, 1995.

–83,.

Thun MJ, Henley S J, et Patrono C.

« Nonsteroidal anti-inflammatory

drugs as anticancer agents:

mechanistic, pharmacologic, and

clinical issues », J. Natl. Cancer Inst.,

vol. 94, no 4, 2002. 252–266.

Sacerdote P, Bianchi M, Manfredi B,

et Panerai A E. « Effects of tramadol

on immune responses and

nociceptive thresholds in mice », Pain,

vol. 72, no 3, , 1997. 325–330.

Malainine M E, Dufresne A, Dupeyre

D, Mahrouz M, Vuong R, et Vignon M

R. « Structure et morphologie des

raquettes et des épines du figuier de

barbarie », Phys Chem News, vol. 1, ,

126–30.

Dongmo A B, Nguelefack T, et

Lacaille-Dubois M.A.« Antinociceptive

and anti-inflammatory activities of

Acacia pennata wild (Mimosaceae) »,

J. Ethnopharmacol., vol. 98, no 1,

–206.

Downloads

Published

30-06-2016

How to Cite

1.
Sihem HALMI, Madi A, Madi A, Berouel K, Lemoui R, Benlakssira B, Hamdi pacha Y. Phytochemical Screening and Analgesic Activity of Opuntia ficus indica cladods extract in Wistar rats. ijp [Internet]. 2016 Jun. 30 [cited 2024 Nov. 21];8(2):282-6. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/468

Issue

Section

Original Research Articles