In vivo neurological assessment of sedative hypnotic effect of Coriandrum sativum L. seeds in mice.


  • Abdulrahman M Alshahrani Department of Internal Medicine College of Medicine Shaqra University Kingdom of Saudi Arabia


Sedative, Hypnotic, Pentobarbital sodium, Coriandrum sativum L.


Ethnopharmacological relevance: seeds of Coriandrum sativum L. have been used in the traditional medicine to relieve stress and other neurological disease conditions. Aim of the study: The present study was under taken to evaluate the sedative hypnotic response of ethanolic extract of seeds of Coriandrum sativum L. (CSEE) in mice. Materials and methods: seeds of Coriandrum sativum L. Ethanolic extract was screened for sedative hypnotic response by using potentiation of Pentobarbital sleeping time at doses of 100mg/kg, 150mg/kg and 200 mg/kg. Saline and Pentobarbital sodium were employed as negative and positive control groups, respectively. Results: Ethanol extract increases Pentobarbital sodium induced sleeping time at dose of 100 mg/kg, 150 mg/kg and 200 mg/kg by 106 %, 111 % and 114% respectively as compared to negative control group and by 06 %, 11% & 14% respectively as compared to positive control group Conclusion: from present study finding it is found that seeds of Coriandrum sativum L. potentiate the sedative hypnotic efficacy in mice.


Franks NP, Lieb WR. What is the molecular nature of general anaesthetic target sites [Abstract] TIPS 1987;8:169–174.

Franks NP,Lieb WR. Which molecular targets are most relevant to general anaesthesia to general anaesthesia [Abstract] Toxicol Lett 1998;Nov. 23: 100–101

Theodore WH, DiChiro G, Margolin R, et al. Barbiturates re- duce human cerebral glucose metabolism [Abstract]. Neurology 1986;36:60–64.

Nemoto EM, Klementavicius R, Melick JA, et al. Suppression of cerebral metabolic rate for oxygen (CMR02) by mild hypothermia compared to thiopental [Abstract]. J Neurosurg Anesthesiol 1996;8:52–59.

CarlssonC,ChapmanAG.Theeffectofdiazepamonthecerebral metabolic state in rats and its interaction with nitrous oxide [Ab- stract]. Anesthesiology 1981;54:488–4 6. Mendelson WB. Human sleep: research and clinical care. New York: Plenum Press, 1987.

Aslam Pathan, Nadeem L. Anxiolytic and analgesic effect of seeds of Coriandrum sativum Linn. Int J of Research in Pharm and Chem 2011; 1(4): 1087-1099.

Aslam Pathan, Abdulrahman Alshahrani, Feras Al-Marshad. Neurological assessment of seeds of Coriandrum sativum L. by using antidepressant and anxiolytic like activity on albino mice, Inventi Impact: Ethnopharmacology, 2015(3):102-105.

Aslam Pathan, Abdulrahman Alshahrani, In vivo neurological assessment of serotonergic response of Coriandrum sativum L seeds in mice, International Journal of Research in Pharmacology & Pharmacotherapeutics 2015; 4(4): 399-405.

Handbook for the Use of Animals in Neuroscience Research, 1997 (updated 18-July-97).

Organization of Economic Co-operation and Development (OECD). The OECD Guidelines for Testing of Chemical: 423 Acute Oral Toxicity, France, 2001

H Gerhard Vogel, Drug discovery and Evaluation- Pharmacological assays, Second edition, Springer Publication, Germany 2002; 495-496.




How to Cite

Abdulrahman M Alshahrani. In vivo neurological assessment of sedative hypnotic effect of Coriandrum sativum L. seeds in mice. ijp [Internet]. 2015 Mar. 31 [cited 2024 Jul. 15];8(1):113-6. Available from:



Original Research Articles