Prevalence of HCV among Drug Addicts in Lahore and its Peripheries


  • Abdul Basit Malik Department of Chemistry, GC University, Lahore Pakistan.
  • Uzma Hanif Department of Chemistry, GC University, Lahore Pakistan.
  • Saleem Bukhari Department of Chemistry, GC University, Lahore Pakistan.
  • Mobina Ulfat Department of Chemistry, GC University, Lahore Pakistan.
  • Saiqa Ishtiaq College of Pharmacy, University of the Punjab.Lahore Pakistan


HCV, Prevalence, IDU`s, Pakistan


HCV continues to be a major health threat globally; approximately 130 million people are infected around the world. The aim of the study was to describe the HCV prevalence in drug addicts the most deprived, isolated and most of the times poor part of our community. This was a cross sectional study focusing the drug addicts under treatment in rehabilitation centers. A total of 92 drug addicts were recruited from four different centers at Lahore including Silverlining Lahore, Silverlining Sheikhupura, Roshan Mustaqbil Lahore and Panah Lahore. All the subjects were tested for HCV RNA PCR, SGPT and SGOT. Out of 92 subjects 23 (25%) were HCV positive and remaining 69 (75%) were HCV negative concluding the drug addicts a higher risk group. Among the HCV positive IDU`s showed a greater percentage 78% (18) and non-IDU`s only 22% (05) proving the injection users the highest risk group. The HCV positive drug users also turned up with a much high SGPT and SGOT levels with a mean of 92 U/L and 72 U/L respectively as compared to that of HCV negative subjects which were 23 U/L and 27 U/L respectively. Drug addicts and specially IDU`s are the highest risk group for developing the HCV infection as concluded by the study and their massive awareness, focus on HCV treatment and also to check the other blood borne diseases are major suggestions advised by the research.


. Afridi S, Naeem M, Hussain A, Kakar

N, Babar ME, and Ahmad J.

Prevalence of hepatitis C virus (HCV)

genotypes in Balochistan. Mol Biol


(2008). pp. 01-04.

. Ahmad N, Asgher M, Shafique M and

Qureshi JA. An evidence of high

prevalence of Hepatitis C virus in

Faisalabad, Pakistan. Saudi Med J. (3):

(2007). 390-395.

. Ahmed F, Irving WL, Anwar M, Myles P

and Neal KR. Prevalence and risk

factors for hepatitis C virus infection in

Kech District, Balochistan, Pakistan:

most infections remain unexplained. A

cross-sectional study. Epidemiol.

Infect. (2012). 140: 716ă723.

. Akbar H, Idrees M, Manzoor S,

Rehman I U, Butt S, Yousaf M Z,

Rafique S, Awan Z, Khubaib B, Akram

M and Aftab M. Hepatitis C virus

infection: A review of the current and

future aspects and concerns in

Pakistan. Journal of General and

Molecular Virology. (2009). 012-018.

. Akhtar S, Moatter T, Azam SI, Rahbar

MH and Adil S. Prevalence and risk

factors for intrafamilial transmission of

hepatitis C virus in Karachi, Pakistan.

Journal of Viral Hepatitis. (2002). 309ă

. Ali A, Ahmad H, Ali I, Khan S A, Zaidi

G and Idrees M. Prevalence of active

hepatitis C virus infection in district

Mansehra Pakistan. Virology Journal.

:334: (2010). 01-05.

. Ali I, Siddique L, Rehman LU, Khan

NU, Iqbal A, Munir I, Rashid F, Khan

SU, Attache S, Swati ZA and Aslam

MS. Prevalence of HCV among the

high risk groups in Khyber

Pakhtunkhwa. Virology Journal. 8:296:

(2011). 01-04.

. Attaullah S, Khan S, and Ali I. Hepatitis

C virus genotypes in Pakistan: a

systemic review. Virology Journal. 8:

: (2011). 02-06.

. Azarkar Z and Sharifzadeh G.

Evaluation of the Prevalence of

Hepatitis B, Hepatitis C, and HIV in

Inmates with Drug-Related Convictions

in Birjand, Iran in 2008. Hepatitis

Monthly. (2010). 26-30.

. Bari A, Akhtar S, Rahbar MH and Luby

SP. Risk factors for hepatitis C virus

infection in male adults in RawalpindiIslamabad, Pakistan. Tropical Medicine

and international Health. (2001). 732-

. Bilwani F, Zaidi Y, Kakepoto GN, Adil

SN and Khurshid M. Prevalence of

Hepatitis C Virus in Lymphoproliferative

Disorders. J Pak Med Assoc.


. Bosan A, Qureshi H, Bile K M, Ahmad I

and Hafiz R. A review of hepatitis viral

infections in Pakistan. J Pak Med

Assoc. (2010). 1045-1058.

. Butt S, Idrees M, Rehman I U, Akbar H,

Shahid M, Afzal S, Younas S and Amin

I. Mixed Genotype Infections with

Hepatitis C Virus, Pakistan. Emerging

Infectious Diseases. 2011). 1565ă

. Fingerhood MI, Jasinsk DR and

Sullivan JT. Prevalence of Hepatitis C

in a Chemically Dependent Population.

ARCH INTERN MED. (1993). 2025-

. Gowenlock AH, McMurry JR,

McLauchlan DM. Varley`s Practical

Clinical Biochemistry sixth edition

(1988) 477-549.

. Hope VD, Judd A, Hickman M,

Lamagni T, Hunter G, Stimson GV,

Jones S, Donovan L, Parry JV and Gill

ON. Prevalence of Hepatitis C Among

Injection Drug Users in England and

Wales: Is Harm Reduction Working?

Am J Public Health. (2001). 38ă42.

. Idrees M, Lal A, Naseem M and Khalid

M. High prevalence of hepatitis C virus

infection in the largest province of

Pakistan. Journal of Digestive

Diseases. (2008). 95-103.

. Iqbal A, Akram M, Ali H, Akhtar N,

Nazir SUR, Ahmad I, Awan A and Asif

H M. Prevalence of Hepatitis C virus

(HCV) in Gadap Town Karachi,

Pakistan. Journal of Medicinal Plants

Research. (2011). 6102-6104.

. Jafri W, Jafri N, Yakoob J, Islam M,

Tirmizi SFA, Jafar T, Akhtar S, Hamid

S, Shah HA and Nizami SQ. Hepatitis

B and C: prevalence and risk factors

associated with seropositivity among

children in Karachi, Pakistan. BMC

Infectious Diseases. (2006). 01-10.

. Khan S, Attaullah S, Ali I, Ayaz S,

Naseemullah, SN Khan, S Siraj and J

Khan Rising burden of Hepatitis C

Virus in hemodialysis patients. Virology

Journal. (2011). 01-05.

. Lauer GM and Bruce DW. Hepatitis C

Virus Infection. N Engl J Med, (2001).


. Mazzaro C, Panarellol G, Carniello S,

Faelli A, Mazzi G, Crovatto M, Baracetti

S, Nascimben F, Zorat F, Pozzato G,

Faccini L and Campanacci L Interferon

versus steroids in patients with

hepatitis C virus-associated

cryoglobulinaemic glomerulonephritis.

DIGEST LIVER DIS. (2000). pp. 708-

. Nafees M, Bhatti MS and Haq IU. SeroPrevalence of HCV Antibodies in

Population Attending Madina Teaching

Hospital, Faisalabad. ANNALS. (2007).

pp. 260-263.

. Pasha O, Luby SP, Khan AJ, Shah SA,

McCormick JB and Hoch SPF.

Household members of hepatitis C

virus-infected people in Hafizabad,

Pakistan: infection by injections from

health care providers. Epidemiol.

Infect. (1999). 515ă518.

. Perz JF, Armstrong GL, Farrington LA,

Hutin YJF and Bell BP. The

contributions of hepatitis B virus and

hepatitis C virus infections to cirrhosis

and primary liver cancer worldwide.

Journal of Hepatology. (2006). 529-

. Qazi HA, Saleem K, Mujtaba I, Hashmi

A, and Soomro JA. Prevalence and

Factors Associated with HCV (Hepatitis

C Virus) Seropositivity in Islamabad,

Pakistan. Acta Medica Iranica. (2010).


. Quaglio GL, Lugoboni F, Pajusco B,

Sarti M, Talamini, GICS, Mezzelani P

and Jarlais DCD. Hepatitis C virus

infection: prevalence, predictor

variables and prevention opportunities

among drug users in Italy. Journal of

Viral Hepatitis. (2003). 394-400.

. Rehman LU, Ullah I, Ali I, Khan IA,

Iqbal A, Khan S, Khan SH, Zaman KU,

Khan NU, Swati ZA and Jahangiri AT.

Active hepatitis C infection and HCV

genotypes prevalent among the IDUs

of Khyber Pakhtunkhwa. Virology

Journal. (2011). 01-04.

. Reyes JC, Colon HM, Robles RR, Rios

E, Matos TD, Negron J, Marrero CA,

Calderon JM and Shepard E.

Prevalence and Correlates of Hepatitis

C Virus Infection among Street

Recruited Injection Drug Users in San

Juan, Puerto Rico. Journal of Urban

Health: Bulletin of the New York

Academy of Medicine. (2006). 11524-


. Shepard CW, Finelli L and Alter MJ.

Global epidemiology of hepatitis C

virus infection. Lancet Infect Dis.

(2005). 558-567.

. Shirin T, Ahmed T, Iqbal A, Islam MU

and Islam MNU. Prevalence and Risk

Factors of Hepatitis B Virus, Hepatitis

C Virus, and Human Immunodeficiency

Virus Infections among Drug Addicts in

Bangladesh. Drug addicts in

Bangladesh 145 J HEALTH POPUL

NUTR. (2000). 145-150.

. Sievert W, Altraif I, Razavi HA, Abdo A,

Ahmed EA, Omair AA, Amarapurkar D,

Chen CH, Dou X, Khayat HE, Shazly

ME, Esmat G, Guan R, Han KH, Koike

K, Largen A, McCaughan G, Mogawer

S, Monis A, Nawaz A, Piratvisuth T,

Sanai FM, Sharara A, Sibbel S, Sood

A, Suh DJ, Wallace C, Young K and

Negro F A. systematic review of

hepatitis C virus epidemiology in Asia,

Australia and Egypt. Liver International.

(2011) .61-80.

. Smyth BP,ÊConnor JJ O, Barry J and

Keenan E. Retrospective cohort study

examining incidence of HIV and

hepatitis C infection among injecting

drug users in Dublin. J Epidemiol

Community Health. (2003). 310ă311.

. Steel RGD and Torrie JH. Principle and

procedures of statistics. Mc Graw Hill.

Book Co. Inc. 2nd New York (USA)


. Taylor DR, Shia ST and Lai MMC.

Hepatitis C virus and interferon

resistance. Microbes and infection.

(2000). 1743-1756.

. Theodore S and Jamal MM

.Epidemiology of Hepatitis C Virus

(HCV) Infection. int. J. Med. Sci.Vol.

ISSN 1449-1907: (2006). 41-46.

. Torres MR. Treatment of hepatitis C

virus infection in drug addicts. Annals

of Hepatology. (suppl. 1): (2006). 60-

. Umar M and Bilal M Hepatitis C, A

Mega Menace: A Pakistani

Perspective. J PAK MED STUD.

(2012). 68-72.

. Umar M, Bushra HT, Ahmad M,

Khurram M, Usman S, Arif M, Adam T,

Minhas Z, Arif A, Naeem A, Ejaz K,

Butt Z and Bilal M. Hepatitis C in

Pakistan: A Review of Available Data.

Hepat Mon. (2010). 205-214.

. Waheed Y, Shafi T, Safi S Z and Qadri

I. Hepatitis C virus in Pakistan: A

systematic review of prevalence,

genotypes and risk factors. World J

Gastroenterology. (2009). 5647-5653.

. Yahya KM and Iqbal K. Presence of

hepatitis C virus infection among

diabetic patients in Faisalabad,

Pakistan. JUMDC. (2011). 13-16.




How to Cite

Abdul Basit Malik, Uzma Hanif, Saleem Bukhari, Mobina Ulfat, Saiqa Ishtiaq. Prevalence of HCV among Drug Addicts in Lahore and its Peripheries. ijp [Internet]. 2015 Sep. 30 [cited 2023 Nov. 29];7(3):337-42. Available from:



Original Research Articles