Prevalence of HCV among Drug Addicts in Lahore and its Peripheries
Keywords:
HCV, Prevalence, IDU`s, PakistanAbstract
HCV continues to be a major health threat globally; approximately 130 million people are infected around the world. The aim of the study was to describe the HCV prevalence in drug addicts the most deprived, isolated and most of the times poor part of our community. This was a cross sectional study focusing the drug addicts under treatment in rehabilitation centers. A total of 92 drug addicts were recruited from four different centers at Lahore including Silverlining Lahore, Silverlining Sheikhupura, Roshan Mustaqbil Lahore and Panah Lahore. All the subjects were tested for HCV RNA PCR, SGPT and SGOT. Out of 92 subjects 23 (25%) were HCV positive and remaining 69 (75%) were HCV negative concluding the drug addicts a higher risk group. Among the HCV positive IDU`s showed a greater percentage 78% (18) and non-IDU`s only 22% (05) proving the injection users the highest risk group. The HCV positive drug users also turned up with a much high SGPT and SGOT levels with a mean of 92 U/L and 72 U/L respectively as compared to that of HCV negative subjects which were 23 U/L and 27 U/L respectively. Drug addicts and specially IDU`s are the highest risk group for developing the HCV infection as concluded by the study and their massive awareness, focus on HCV treatment and also to check the other blood borne diseases are major suggestions advised by the research.
References
. Afridi S, Naeem M, Hussain A, Kakar
N, Babar ME, and Ahmad J.
Prevalence of hepatitis C virus (HCV)
genotypes in Balochistan. Mol Biol
Rep.10.1007/s11033-008-9342-0.
(2008). pp. 01-04.
. Ahmad N, Asgher M, Shafique M and
Qureshi JA. An evidence of high
prevalence of Hepatitis C virus in
Faisalabad, Pakistan. Saudi Med J. (3):
(2007). 390-395.
. Ahmed F, Irving WL, Anwar M, Myles P
and Neal KR. Prevalence and risk
factors for hepatitis C virus infection in
Kech District, Balochistan, Pakistan:
most infections remain unexplained. A
cross-sectional study. Epidemiol.
Infect. (2012). 140: 716ă723.
. Akbar H, Idrees M, Manzoor S,
Rehman I U, Butt S, Yousaf M Z,
Rafique S, Awan Z, Khubaib B, Akram
M and Aftab M. Hepatitis C virus
infection: A review of the current and
future aspects and concerns in
Pakistan. Journal of General and
Molecular Virology. (2009). 012-018.
. Akhtar S, Moatter T, Azam SI, Rahbar
MH and Adil S. Prevalence and risk
factors for intrafamilial transmission of
hepatitis C virus in Karachi, Pakistan.
Journal of Viral Hepatitis. (2002). 309ă
. Ali A, Ahmad H, Ali I, Khan S A, Zaidi
G and Idrees M. Prevalence of active
hepatitis C virus infection in district
Mansehra Pakistan. Virology Journal.
:334: (2010). 01-05.
. Ali I, Siddique L, Rehman LU, Khan
NU, Iqbal A, Munir I, Rashid F, Khan
SU, Attache S, Swati ZA and Aslam
MS. Prevalence of HCV among the
high risk groups in Khyber
Pakhtunkhwa. Virology Journal. 8:296:
(2011). 01-04.
. Attaullah S, Khan S, and Ali I. Hepatitis
C virus genotypes in Pakistan: a
systemic review. Virology Journal. 8:
: (2011). 02-06.
. Azarkar Z and Sharifzadeh G.
Evaluation of the Prevalence of
Hepatitis B, Hepatitis C, and HIV in
Inmates with Drug-Related Convictions
in Birjand, Iran in 2008. Hepatitis
Monthly. (2010). 26-30.
. Bari A, Akhtar S, Rahbar MH and Luby
SP. Risk factors for hepatitis C virus
infection in male adults in RawalpindiIslamabad, Pakistan. Tropical Medicine
and international Health. (2001). 732-
. Bilwani F, Zaidi Y, Kakepoto GN, Adil
SN and Khurshid M. Prevalence of
Hepatitis C Virus in Lymphoproliferative
Disorders. J Pak Med Assoc.
(2004).202-206.
. Bosan A, Qureshi H, Bile K M, Ahmad I
and Hafiz R. A review of hepatitis viral
infections in Pakistan. J Pak Med
Assoc. (2010). 1045-1058.
. Butt S, Idrees M, Rehman I U, Akbar H,
Shahid M, Afzal S, Younas S and Amin
I. Mixed Genotype Infections with
Hepatitis C Virus, Pakistan. Emerging
Infectious Diseases. 2011). 1565ă
. Fingerhood MI, Jasinsk DR and
Sullivan JT. Prevalence of Hepatitis C
in a Chemically Dependent Population.
ARCH INTERN MED. (1993). 2025-
. Gowenlock AH, McMurry JR,
McLauchlan DM. Varley`s Practical
Clinical Biochemistry sixth edition
(1988) 477-549.
. Hope VD, Judd A, Hickman M,
Lamagni T, Hunter G, Stimson GV,
Jones S, Donovan L, Parry JV and Gill
ON. Prevalence of Hepatitis C Among
Injection Drug Users in England and
Wales: Is Harm Reduction Working?
Am J Public Health. (2001). 38ă42.
. Idrees M, Lal A, Naseem M and Khalid
M. High prevalence of hepatitis C virus
infection in the largest province of
Pakistan. Journal of Digestive
Diseases. (2008). 95-103.
. Iqbal A, Akram M, Ali H, Akhtar N,
Nazir SUR, Ahmad I, Awan A and Asif
H M. Prevalence of Hepatitis C virus
(HCV) in Gadap Town Karachi,
Pakistan. Journal of Medicinal Plants
Research. (2011). 6102-6104.
. Jafri W, Jafri N, Yakoob J, Islam M,
Tirmizi SFA, Jafar T, Akhtar S, Hamid
S, Shah HA and Nizami SQ. Hepatitis
B and C: prevalence and risk factors
associated with seropositivity among
children in Karachi, Pakistan. BMC
Infectious Diseases. (2006). 01-10.
. Khan S, Attaullah S, Ali I, Ayaz S,
Naseemullah, SN Khan, S Siraj and J
Khan Rising burden of Hepatitis C
Virus in hemodialysis patients. Virology
Journal. (2011). 01-05.
. Lauer GM and Bruce DW. Hepatitis C
Virus Infection. N Engl J Med, (2001).
-56.
. Mazzaro C, Panarellol G, Carniello S,
Faelli A, Mazzi G, Crovatto M, Baracetti
S, Nascimben F, Zorat F, Pozzato G,
Faccini L and Campanacci L Interferon
versus steroids in patients with
hepatitis C virus-associated
cryoglobulinaemic glomerulonephritis.
DIGEST LIVER DIS. (2000). pp. 708-
. Nafees M, Bhatti MS and Haq IU. SeroPrevalence of HCV Antibodies in
Population Attending Madina Teaching
Hospital, Faisalabad. ANNALS. (2007).
pp. 260-263.
. Pasha O, Luby SP, Khan AJ, Shah SA,
McCormick JB and Hoch SPF.
Household members of hepatitis C
virus-infected people in Hafizabad,
Pakistan: infection by injections from
health care providers. Epidemiol.
Infect. (1999). 515ă518.
. Perz JF, Armstrong GL, Farrington LA,
Hutin YJF and Bell BP. The
contributions of hepatitis B virus and
hepatitis C virus infections to cirrhosis
and primary liver cancer worldwide.
Journal of Hepatology. (2006). 529-
. Qazi HA, Saleem K, Mujtaba I, Hashmi
A, and Soomro JA. Prevalence and
Factors Associated with HCV (Hepatitis
C Virus) Seropositivity in Islamabad,
Pakistan. Acta Medica Iranica. (2010).
-398.
. Quaglio GL, Lugoboni F, Pajusco B,
Sarti M, Talamini, GICS, Mezzelani P
and Jarlais DCD. Hepatitis C virus
infection: prevalence, predictor
variables and prevention opportunities
among drug users in Italy. Journal of
Viral Hepatitis. (2003). 394-400.
. Rehman LU, Ullah I, Ali I, Khan IA,
Iqbal A, Khan S, Khan SH, Zaman KU,
Khan NU, Swati ZA and Jahangiri AT.
Active hepatitis C infection and HCV
genotypes prevalent among the IDUs
of Khyber Pakhtunkhwa. Virology
Journal. (2011). 01-04.
. Reyes JC, Colon HM, Robles RR, Rios
E, Matos TD, Negron J, Marrero CA,
Calderon JM and Shepard E.
Prevalence and Correlates of Hepatitis
C Virus Infection among Street
Recruited Injection Drug Users in San
Juan, Puerto Rico. Journal of Urban
Health: Bulletin of the New York
Academy of Medicine. (2006). 11524-
-9109-7.
. Shepard CW, Finelli L and Alter MJ.
Global epidemiology of hepatitis C
virus infection. Lancet Infect Dis.
(2005). 558-567.
. Shirin T, Ahmed T, Iqbal A, Islam MU
and Islam MNU. Prevalence and Risk
Factors of Hepatitis B Virus, Hepatitis
C Virus, and Human Immunodeficiency
Virus Infections among Drug Addicts in
Bangladesh. Drug addicts in
Bangladesh 145 J HEALTH POPUL
NUTR. (2000). 145-150.
. Sievert W, Altraif I, Razavi HA, Abdo A,
Ahmed EA, Omair AA, Amarapurkar D,
Chen CH, Dou X, Khayat HE, Shazly
ME, Esmat G, Guan R, Han KH, Koike
K, Largen A, McCaughan G, Mogawer
S, Monis A, Nawaz A, Piratvisuth T,
Sanai FM, Sharara A, Sibbel S, Sood
A, Suh DJ, Wallace C, Young K and
Negro F A. systematic review of
hepatitis C virus epidemiology in Asia,
Australia and Egypt. Liver International.
(2011) .61-80.
. Smyth BP,ÊConnor JJ O, Barry J and
Keenan E. Retrospective cohort study
examining incidence of HIV and
hepatitis C infection among injecting
drug users in Dublin. J Epidemiol
Community Health. (2003). 310ă311.
. Steel RGD and Torrie JH. Principle and
procedures of statistics. Mc Graw Hill.
Book Co. Inc. 2nd New York (USA)
(1982)..
. Taylor DR, Shia ST and Lai MMC.
Hepatitis C virus and interferon
resistance. Microbes and infection.
(2000). 1743-1756.
. Theodore S and Jamal MM
.Epidemiology of Hepatitis C Virus
(HCV) Infection. int. J. Med. Sci.Vol.
ISSN 1449-1907: (2006). 41-46.
. Torres MR. Treatment of hepatitis C
virus infection in drug addicts. Annals
of Hepatology. (suppl. 1): (2006). 60-
. Umar M and Bilal M Hepatitis C, A
Mega Menace: A Pakistani
Perspective. J PAK MED STUD.
(2012). 68-72.
. Umar M, Bushra HT, Ahmad M,
Khurram M, Usman S, Arif M, Adam T,
Minhas Z, Arif A, Naeem A, Ejaz K,
Butt Z and Bilal M. Hepatitis C in
Pakistan: A Review of Available Data.
Hepat Mon. (2010). 205-214.
. Waheed Y, Shafi T, Safi S Z and Qadri
I. Hepatitis C virus in Pakistan: A
systematic review of prevalence,
genotypes and risk factors. World J
Gastroenterology. (2009). 5647-5653.
. Yahya KM and Iqbal K. Presence of
hepatitis C virus infection among
diabetic patients in Faisalabad,
Pakistan. JUMDC. (2011). 13-16.