Medicinal Plants on Acne inducing Bacteria


  • Ankita Das Raja N. L. Khan Women's College, Midnapore. India INSPIRE Fellow, Department of Physiology, Raja N. L. Khan Women's College, Midnapore.


Acne, Acne vulgaris, MIC, MBC


Acne is a cutaneous pleomorphic disorder of the pilosebaceous unit involving abnormalities in sebum production and is characterized by both inflammatory (papules, pustules and nodules) and non-inflammatory (comedons, open and closed) lesions. Propionibacterium acnes and Staphylococcus epidermidis are common pus-forming microbes responsible for the development of various forms of Acne vulgaris. The present study was conducted to evaluate antimicrobial activities of seven medicinal plants against acne-inducing bacteria. Acetonic and aqueous extracts of Azadirachta indica (leaves), Curcuma longa (root), Aloe vera (leaves), Withania somnifera (leaves), Terminalia arjuna (bark), Ocimim sanctum (leaves), Santalum album (wood) were tested for antimicrobial activities by agar diffusion, Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) methods. The results from the agar diffusion method showed that five medicinal plants could inhibit the growth of acne-inducing bacteria. Among these Azadirachta indica, Curcuma longa and Terminalia arjuna had strong inhibitory effects. Based on MIC, the acetonic extracts of Azadirachta indica and Curcuma longa had the greatest antimicrobial effects. Taken together, the present study indicated that Azadirachta indica had a strong inhibitory effect on acne-inducing bacteria.


. Ayres S. Jr, and Mihan R. Acne

vulgaris: therapy directed at

pathophysiologic defects. International

Journal of Dermatology, 1981. 20:616.

DOI: 10.1111/j.1365-


. Bojar RA, Eady EA, Jones CE, Cunliffe

WJ and Holland KT. Inhibition of

erythromycin-resistant propionibacteria

on the skin of acne patients by topical

erythromycin with and without zinc.

British Journal of Dermatology, 1994.

:329. DOI: 10.1111/j.1365-


. Darley CR, Moore JW, Besser GM,

Munro DD, Edwards CR, Rees LH and

Kirby JD. Androgen status in women

with late onset or persistent acne

vulgaris. Clinical and Experimental

Dermatology, 1984. 9:28. DOI:


. Epstein M. The growing role of calcium

antagonists in treating hypertension in

the elderly. The American Journal of

Geriatric Cardiology, 2000. 9:42-48

DOI: 10.1111/j.1076-


. Ghosh V K. Different approaches of

alternative medicines in acne vulgaris

treatment. Orient Pharm Exp. Med; et

al., 2011 ,11:1-9 DOI:


. Jacobs DG, Deutsch NL and Brewer

M. Suicide, depression, and

isotretinoin: is there a causal link? J

Am Acad Dermatol; 2001.45:S168-

S175. DOI: 10.1067/mjd.2001.118233

. Klassen AF, Newton JN and Mallon E.

Measuring quality of life in people

referred for specialist care of acne:

Comparing generic and diseasespecific measures. J AM Acad

Dermatol; 2000. 43:229-33. DOI:


. Kligman AM, Jr. Mills OH, Leyden JJ,

Gross PR. Allen HB and Rudolph RI.

Oral vitamin A in acne vulgaris.

Preliminary report. International Journal

of Dermatology, 1981.20:278-285 DOI:


. Koo JY and Smith LL. Psychologic

Aspects of Acne. Ped Dermatol

;8:185-8. DOI: 10.1111/j.1525-


. Krowchuk DP, Stancin T, Keskinen R,

Walker R, Bass J and Anglin TM.. The

psychosocial effects of acne in

adolescents. Pediatric Dermatol, 1991.

:332-8. DOI: 10.1111/j.1525-


. Lasek RJ. and Chren MM. Acne

Vulgaris and the Quality of Life of Adult

Dermatology Patients. Arch Derm,

134:454-8. DOI:


. McCarty, M., 1984. High-chromium

yeast for acne? Medical Hypotheses,

:307-310 DOI: 10.1016/0306-


. Michaelsson G, Juhlin L. and Vahlquist

A. Effects of oral zinc and vitamin A in

acne. Arch derm 1977a.113:31-36 DOI:


. Michaelsson G, Vahlquist A and Juhlin

L. Serum zinc and retinol-binding

protein in acne. Br J Dermatol, 1977b.

:283. DOI: 10.1111/j.1365-


. Michaelsson G, Juhlin L. and Ljunghall

K. A double-blind study of the effect of

zinc and oxytetracycline in acne

vulgaris . Br J Dermatol, 1977c.

:561. DOI: 10.111/j.1365-


. Nand P, Drabu S, Gupta RK,

Insignificant anti-acne activity of

Azadirachta indica leaves and bark. J

Pharm negative results. 2012. 3: 29-33.

. Newton JN, Mallon E, Klassen A, Ryan

TJ and Finlay AY. The effectiveness of

acne treatment: an assessment by

patients of the outcome of therapy. Br J

Dermatol 1997.137: 563-7. DOI:


. Paraskevaidis A, Drakoulis N, Roots I,

Orfanos CE and Zouboulis

CC.,Polymorphisms in the human

cytochrome P-450 1A1 gene (CYP1A1)

as a factor for developing acne.

Derematology, 1998. 196:171. DOI:


. Randle HW, Diaz-Perez JL and

Winkelmann RK. Toxic doses of

vitamin A for pityriasis rubra pilaris.

Arch Derm, 1980.116:888. DOI:


. Rubinow DR, Peck GL, Squillace KM

and Gantt GG. Reduced anxiety and

depression in cystic acne patients after

successful treatment with oral

isotretinoin. J Am Acad Dermatol,

17:25-32. DOI: 10.1016/s0190-


. Ruiz-Maldonado R, Tamayo-Sanchez

L.and de La Luz Orozco-Covarrubias

M. The use of retinoids in the pediatric

patient. Dermatologic Clinics, 1998.

:553. DOI: 10.1016/s0733-


. Sansone G. and Reisner RM.

Differential rates of conversion of

testosterone to dihydrotestosterone in

acne and in normal human skin--a

possible pathogenic factor in acne.

Journal of Investigative Dermatology,

56:366. DOI: 10.1111/1523-


. Schiavone FE, Rietschel RL, Sgoutas

D and Harris R. Elevated free

testosterone levels in women with

acne. Arch Derm, 1983. 119:799. DOI:


. Sunday E. Atawadi and Joy C.

Atawadi. Phytochem Rev. 2009.8:601-

DOI: 10.1007/s11101-00909144-

. Symes EK, Bender DA, Bowden JF

and Coulson WF. Increased target

tissue uptake of, and sensitivity to,

testosterone in the vitamin B6 deficient

rat. Journal of Steroid Biochemistry,

20:1089. DOI: 10.1016/0022-

(84) 90348-0

. Takayasus S, Wakimoto H, Itami S and

Sano S. Activity of testosterone 5

alpha-reductase in various tissues of

human skin. Journal of Investigative

Dermatology, 1980. 74:187. DOI:


. Tan JK, Vasey K and Fung KY. Beliefs

and Perceptions of patients with acne.

J AM Acad Dermatol, 2001. 44:439-45.

DOI: 10.1067/mjd.2001.111340

. Thomas JR, Cooke JP and

Winkelmann RK. High-dose vitamin A

therapy for Darier's disease. Arch

Derm, 1982.118:891. DOI:


. Tschesche R. Advances in the

chemistry of antibiotics substances

from higher plants: Pharmacognosy

and phytochemistry. Springer-Verlag,

Berlin Heidelberg, New York:

274-289. DOI: 10.1007/978-3-


. Weimar VM, Puhl SC, Smith WH and

Broeke JET. Zinc sulfate in acne

vulgaris. Arch Derm, 1978.114:1776.






How to Cite

Tanushree Tulsian Samanta, Ankita Das. Medicinal Plants on Acne inducing Bacteria. ijp [Internet]. 2015 Sep. 30 [cited 2023 Nov. 29];7(3):310-5. Available from:



Original Research Articles