Free radical scavenging activity of an aerial part of Aconitum heterophyllum (wall) from Kashmir Himalayas, India


  • Ayaz Ahmed Govt. NMV Hoshangabad, M.P India.
  • Ranjana Singh Govt. NMV Hoshangabad, M.P India.
  • Ravi Upadhyay Govt. NMV Hoshangabad, M.P India..


Aconitum heterophyllum (wall), Kashmir Himalayas, Free radical scavenging activity


The plant Aconitum heterophyllum native to Kashmir has been widely used as a traditional medicine to cure diseases associated inflammations, cardiovascular, neurodegenerative and other ailments, microbial, bronchitis and joint pains since times. Keeping this in view the present study was carried out to investigate the antioxidant potential and the phytoconstituents composition of the plant extract. Various compounds were detected in the preliminary screening of the leaf extract of the plant, among them were the dominance of alkaloids and flavanoids. Wide range of antioxidant activity was detected in the plant compared to the standard antioxidants.


. Maqsood S, Singh P, Samoon MH,

Balange AK. Effect of dietary chitosan

on non-specific immune response and

growth of Cyprinus carpio challenged

with Aeromonas hydrophila. Inter Aqua

Res. 2010; 2:77-85.

. Zengin G, Cakmak YS, Guler GO,

Aktumsek A. Antioxidant properties of

methanolic extract and fatty acid

composition of Centaurea urvillei. Rec

Nat Prod. 2011; 5:123-132.

. Vongtau HO, Abbah J, Chindo BA,

Mosugu O, Salawu AO, Kwanashie

HO, Gamaniel KS: Central inhibitory

effects of the methanol extract of

Neorautanenia mitis root in rats and

mice. J Pharm Biol. 2005; 43:113-120.

. Oluyemi KA, Okwuonu UC, Baxter DG,

Oyesola TO. Toxic effects of

methanolic exract of Aspilia africana

leaf on the estrous cycle and uterine

tissues of Wistar rats. Int J Morphol.

; 25:609-614.

. Halliwell B, Gutteridge JMC. Formation

of thiobarbituric acid reactive

substances from deoxyribose in the

presence of iron salts: the role of

superoxide and hydroxyl radicals.

FEBS Lett. 1981; 128:347-352.

. Nunes XP, Silva FS, Almeida JR GDS,

Barbosa Filho JM, de Lima JT, de

Araujo Ribeiro LA, and Junior

LJQ. Biological oxidations and

antioxidant activity of natural products.

INTECH Open Access Publisher.2002.

. Wannes WA, Mhamdi B, Sriti J, Jemia

MB, Ouchikh O, Hamdaoui G, Kchouk

ME, Marzouk B: Antioxidant activities

of the essential oil and methanol

extracts from myrtle (Myrtus communis

var. italica L.) leaf, stem and flower.

Food Chem Toxicol. 2010; 48:1362-

. Zhao K, Penttinen P, Guan T, Xiao J,

Chen Q, Xu J and Strobel GA. The

diversity and anti-microbial activity of

endophytic actinomycetes isolated from

medicinal plants in Panxi plateau,

China. Current microbiology.


. Khandelwal KR. Pune: Nirali

Prakashan; Practical Pharmacognosy.

; 149-53.

. Sharma Om P and Tej K Bhat. "DPPH

antioxidant assay revisited." Food

chemistry. 113.4 (2009): 1202-1205.

. Braca A, Fico G, Morelli I, De Simone

F, Tome F and De Tommasi N. (2003).

Antioxidant and free radical scavenging

activity of flavonol glycosides from

different Aconitum species. Journal of

Ethnopharmacology. 2003; 86 (1): 63-

. Prasad SK, Kumar R, Patel DK, Sahu

AN, and Hemalatha S.

Physicochemical standardization and

evaluation of in-vitro antioxidant activity

of Aconitum heterophyllum Wall. Asian

Pacific Journal of Tropical Biomedicine.

2 (2):526-531.

. Wanasundara UN, Shahidi F.

Antioxidant and pro-oxidant activity of

green tea extracts in marine oils. Food

Chem. 1996; 63:335-342.

. Prasad SK, Singh PN, Wahi AK,

Hemalatha S. Pharmacognostical

standardization of Withania coagulans

Dunal. Pharmacog J. 2010; 2: 386-394.

. Rathbone DA, Bruce NC. Microbial

transformation of alkaloids. Curr Opin

Microbiol. 2002; 5: 274-281.

. Patel DK, Kumar R, Prasad SK, Sairam

K, Hemalatha S. Antidiabetic and in

vitro antioxidant potential of Hybanthus

enneaspermus linn f. muell in

streptozotocin-induced-diabetic rats.

Asian Pac J Trop Biomed. 2011; 1:316-

. Patel DK, Kumar R, Laloo D, Sairam K,

Hemalatha S. Evaluation of

phytochemical and antioxidant

activities of the different fractions of

Hybanthus enneaspermus (Linn.) F.

Muell. (Violaceae). Asian Pac J Trop

Med. 2011; 4: 391-396.

. Govindarajan M, Jebanesan A, Reetha

D, Amsath R, Pushpanathan T,

Samidurai K. Antibacterial activity of

Acalypha indica L. Eur. Rev. Med.

Pharmacol. Sci. 2008; 12: 299-302.




How to Cite

Ayaz Ahmed, Ranjana Singh, Ravi Upadhyay. Free radical scavenging activity of an aerial part of Aconitum heterophyllum (wall) from Kashmir Himalayas, India. ijp [Internet]. 2015 Sep. 30 [cited 2024 Jun. 17];7(3):240-5. Available from:



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