Antimicrobial Activity of Piper aduncum subsp ossanum Essential Oil
Keywords:
Piper aduncum subsp. ossanum, essential oil, camphor, camphene, antimicrobial, CubaAbstract
Plants are an important source for new antimicrobials. Piper aduncum L. (Piperaceae) is a medicinal plant use traditionally in South America and The Caribbean Basin. In Cuba, P. aduncum subsp. ossanum (C.CD.) Saralegui has ethnomedical reports as haemostatic, diuretic and, in urinary infection and skin infection. Ethanolic extract and essential oil obtained from this subspecie was tested by agar disc diffusion method against four strains of Escherichia coli (two uropathogenic clinical isolated), Staphylococcus aureus and Candida albicans. In all microorganisms a moderate or poor antimicrobial effect was exerted; but some activity was found against resistant sulfametoxazol or vancomicine E. coli strains. S. aureus and C. albicans were noted as the most sensitive microorganisms. Monoterpene camphor, present in the essential oil as main compounds could be responsible of the activity. These findings may support traditional use of this subspecie as antiseptic in Cuba.
References
. Perumal SR, Gopalakrishnakone, P. Therapeutic Potential of Plants as Anti-microbials for Drug Discovery. Evid Based Complement Altern Med. 2010;7(3):283-294.
. Abreu O, Cuéllar A. Estrategias en la selección de las plantas medicinales a investigar. Revista Cubana Plantas Medicinales 2008;13.
. Ríos JL, Recio MC. Medicinal plants and antimicrobial activity. J Ethnopharmacol. 2005;100,80-84.
. Saralegui H. Piperaceae. In: Greuter W, Rankin R editors. Flora de la República de Cuba, Serie A, Plantas Vasculares, Fascículo 9 (3), Königstein; 2004. p.81.
. Roig JT. Plantas Medicinales, Aromáticas o Venenosas de Cuba. Cuba. Parte II. Ministerio de Agricultura, La Habana; 1945. p. 363-365.
. Hartemink AE. The invasive shrub Piper aduncum in Papua New Guinea: a review. J. Trop. Forest Sci. 2010;22(2):202-213.
. Abreu OA, Rodríguez AA, Morgado M, Cao LB. Farmacognosia, farmacobotánica, farmacogeografía y farmacoetimología del platanillo de Cuba (Piper aduncum subespecie ossanum). Revista Cubana de Plantas Medicinales 2012;17(2).
. Seoane J. El folclor médico de Cuba. Editorial Ciencias Sociales, La Habana; 1984. p. 896.
. Fuentes VR, Rodríguez M, Poucheaux M, Cabrera L, Lara S. Estudios en la medicina tradicional en Cuba. II. Bol Res Plant Med. 1985;5:13-40.
. Fuentes VR, Granda MM. Estudios de la Medicina Tradicional en Cuba. III. Rev Cub Farm. 1988; 22(3):77-90.
. Dr Duke´s Phytochemical & Ethnobotanical Database. Available at http://www.ars-grin.gov/duke/; Accessed Nov 2007.
. Tirillini B, Rojas E, Pellegrino R. Chemical composition and antimicrobial activity of essential oil of Piper angustifolium. Planta Med. 1996;62(4):372-373.
. de Oliveira JCS, Dias IJM, da Camara, CAG, Schwartz MOE. Volatile Constituents of the leaf oils of Piper aduncum L. from different regions of Pernambuco (Northeast of Brazil). Journal of Essential Oil Research 2006;18(5):557-9.
. Cicció JF, Ballestero CM. Constituyentes volátiles de las hojas y espigas de Piper aduncum (Piperaceae) de Costa Rica. Rev Biol Trop. 1997;45,783-790.
. Pino J, Marbot R, Bello A, Urquiola A. Essential oils of Piper peltata (L.) Miq. and Piper aduncum L. from Cuba. Journal of Essential Oil Research 2004;16;124-126.
. Rali T, Wossa SW, Leach DN, Waterman PG. Volatile Chemical Constituents of Piper aduncum L. and Piper gibbilimbum C. DC (Piperaceae) from Papua New Guinea. Molecules 2007;12,389-94.
. Duarte MCT, Leme EE, Delarmelina C, Soares AA, Figueira GM, Sartoratto A. Activity of essential oils from Brazilian medicinal plants on Escherichia coli. J. Ethnopharmacol. 2007;111, 197-201.
. Guerrini A, Sacchetti G, Rossi D, Paganetto G, Muzzoli M, Andreotti E, Tognolini M, Maldonado ME, Bruni R. Bioactivities of Piper aduncum L. and Piper obliquum Ruiz & Pavon (Piperaceae) essential oils from Eastern Ecuador. Env Toxi Pharm. 2009;27,39-48.
. Apecechea MR, Larionova M, Salazar S, Abín G. Evaluación de la actividad antiulcerosa del 2"-0-ramnosil 4"-0-metil-vitexina de las hojas de Piper ossanum. Rev Cubana Med Milit 2000;29(2):114-7.
. González M, Larionova M, Martínez AM, Marrero O. Evaluación de la acción antiinflamatoria del producto FL-1. Rev Cub Med Mil 2003;8(2).
. Martínez C, García M, Martínez SM, Larionova M, Sebazco C, Machín M, Ruiz V. Evaluación antiinflamatoria del flavonoide 2"-o- ramnosil 4"-o- metil vitexina en ratas. Rev Cubana Plant Med 2004;9(1).
. Abreu O, Pino JA. Leaf Oil Composition of Piper aduncum subsp. ossanum (C. CD.) Saralegui from Cuba. Nat. Prod. Commun. 2008;3, 271-273.
. NCCLS. Performance standars for antimicrobials disck suceptibility tests. 2000.
. T. Gumbo. General Principles of Antimicrobial Therapy. In: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e. LL. Brunton (Ed.) McGraw-Hill Global Education Holdings, 2006.
. Tegos G, Stermitz, FR, Lomovskaya O, Lewis K. Multidrug Pump Inhibitors Uncover Remarkable Activity of Plant Antimicrobials. Antimicrobial Agents and Chemotherapy 2002;46,3133-3141.
. Hemaiswarya S, Kruthiventi AK, Doble M. Synergism between natural products and antibiotics against infectious diseases. Phytomedicine 2008;15,639-652.
. Henrici, T. The Staining of Yeasts by Gram's Method. J Med Res. 1914;30(3):409-416.
. Brooks GF, Carroll KC, Butel JS, Morse SA, Mietzner TA. (eds.) Jawetz, Melnick, & Adelberg's Medical Microbiology. 26th ed. New York: McGraw-Hill; 2013.
. Okunade AL, Hufford CD, Clark AM, Lentz D. Antimicrobial properties of the constituents of Piper aduncum. Phytother. Res. 1997;11,142-144.
. Cáceres A, Jauregui E, Herrera D, Logemann H. Plants used in Guatemala for the treatment of dermatomucosal infections. 1: screening of 38 plant extracts for anticandidal activity. J. Ethnopharmacol. 1991;33(3):277-283.
. Orjala J, Wright AD, Behrends H, Folkers G, Sticher O, Ruegger H, Rali T. Cytotoxic and antibacterial dihydrochalcones from Piper aduncum. J. Nat. Prod. 1994;57, 18-26.
. Kloucek P, Polesny Z, Svobodova B, Vlkova E, Kokoska L. Antibacterial screening of some Peruvian medicinal plants used in Calleria District. J. Ethnopharmacol. 2005;99, 309-12.
. Birdi, T, Daswani P, Brijesh S, Tetali P, Natu A, Antia N. Newer insights into the mechanism of action of Psidium guajava L. leaves ininfectious diarrhoea. BMC Compl. Alt. Med. 2010;10,33.
. Barreto G, Campal A, Abreu O, Velásquez B. El bloqueo de la adhesión fimbrial como opción terapéutica. Revista de Producción Animal 2001;13(1),71-82.
. Tong Y, Wu Q, Zhao D, Liu Y, Cao M, Zhang L, Zheng S. Effects of chinese herbs on the hemagglutination and adhesion of Escherichia coli strain in vitro. African Journal of Traditional, Complementary and Alternative Medicines 2011;8(1): 82-87.
. Abreu O, Barreto G. Antiadhesive Antibacterial Effect of Plant Compounds. In: Phytochemicals as Nutraceuticals - Global Approaches to Their Role in Nutrition and Health. V. Rao, editor InTech. 2012. Available from: http://www.intechopen.com/books/phytochemicals-as-nutraceuticals-global-approaches-to-their-role-in-nutrition-and-health/antiadhesive-antibacterial-effect-of-plant-compounds