Antitumor activity of methanolic extract of Cyclea peltata

Authors

  • Meena J Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore India.
  • Santhy Anandan Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore India.

Keywords:

Cyclea peltata, cell lines, phyconstitutent, methanol, anticancer

Abstract

Phytocompound based drugs are soon gaining popularity as alternates for treatment of chronic and serious illness. Cyclea peltata has largely been classified as medicinal plant and used to treat various illness. Soxhlet based extraction of the plant was carried out using various solvents and subjected to chromatographic analysis to understand the variety of phytoconstituents present in the crude extract of the plant. Invitro and invivo testing for anticancer activity of the methanolic extract of the plant revealed potent significance among the haematological and cytotoxic parameters. The results, thus, indicate efficacy for anticancer activity although the main constituent of the crude extract is yet to be established.

References

Xia M, Wang D, Wang M, Tashiro S, Onodera S, Minami M. Dracorhodin percholarate induces apoptosis via activation of caspases and generation of reactive oxygen species. J Pharmacol Sci 2004; 95:273 – 283.

Ved DK, Goraya GS. Demand and supply of medicinal plants in India. Report published by National Medicinal Plants Board, New Delhi and Foundation for Revitalization of Local Health Traditions, Bangalore, (2007).

Ranjith NP, Ramachandran VS. Ethnomedicines of Kurichiyas, Kannur District, Western Ghats, Kerala. Ind J Nat Prod Res 2010; 1:233- 249.

Clarkson BD, Burchenal JH. Preliminary screening of antineoplastic drugs. Prog. Clin Can 1965; 1:625-629.

Prasad SB, Giri A. Antitumor effect of cisplatin against murine ascites Dalton's lymphoma. Ind J Expt Biol 1994; 32:155-162.

Khan TA, Zafar F. Haematological Study in Response to Varying Doses of Estrogen in Broiler Chicken. Int J Poul Sci 2005; 4(10): 748-751.

Isaac LJ, Abah G, Akpan B, Ekaette IU. Haematological properties of different breeds and sexes of rabbits. Proceedings of the 18th Annual Conference of Animal Science Association of Nigeria (2013).

Awodi S, Ayo JO, Atodo AD, Dzende T. Some haematological parameters and the erythrocyte osomotic fragility in the laughing dove (Streptopella senegalensis) and the village weaner bird (Ploceus cucullatus). Proceedings of the 10th Annual Conference of Animal Science Association of Nigeria. (2005).

Chineke CA, Ologun AG, Ikeobi CON. Haematological parameters in rabbit breeds and crosses in humid tropics. Pak J Biol Sci 2006; 9(11): 2102-2106.

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Published

30-06-2015

How to Cite

1.
Meena J, Santhy Anandan. Antitumor activity of methanolic extract of Cyclea peltata. ijp [Internet]. 2015 Jun. 30 [cited 2024 Jun. 17];7(2):185-92. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/403

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Section

Original Research Articles