Evaluation of hypoglycemic properties and fertility effect of Piper sarmantosum Roxb. aqueous leaf extract in streptozotocin induced diabetic mice

Authors

  • Ampa - Luangpirom Biology Department Associate Professor, Khon Kaen University Thailand.
  • Watchara Kourchampa Department of Biology, Faculty of Science, Khon Kaen University Thailand
  • Pichet Somsapt Depaertment of Radiology, Faculty of Medicine, Khon Kaen University Thailand

Keywords:

hyperglycemic properties, fertility effect, insulin, Piper sarmentosum Roxb

Abstract

Male mice of ICR strain (6-7 week old, 30-40 g) were used for evaluation of the hypoglycemic and fertility effect of Piper sarmentosum Roxb. leaf extract. Diabetes was induced by intraperitoneal (i.p) injection of streptozotocin (STZ) (6.0 mg/100gBW) and glibenclamide (reference drug) 1 mg/ 100gBW and Piper sarmentosum Roxb. leaf extract (PS) at 60 and 100 mg/100gBW were orally administered (per os) for 21 days. The hypoglycemic activity of PS was 73.04 and 120.96% of the glibenclamide. Meanwhile, the blood insulin level also significantly increased by 8.25 and 50.53 % of the diabetic control. The concordant results showed that diabetic pancreatic islets were impaired and improved after extract treatment. However, the fertility status test showed that the seminal quality and blood testosterone of diabetic mice decreased significantly (P< 0.05) as compared to the normal mice and significantly increased when compared to the diabetic control after long-term treatment. In conclusion, Piper sarmentosum Roxb. aqueous leaf extract at doses of 60 and 100 mg/100 gBW revealed hyperglycemic properties in diabetic mice. They also improved both pancreatic islet function and fertility status of diabetic mice after 21 days of extract treatment.

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Published

30-09-2014

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1.
Ampa - Luangpirom, Watchara Kourchampa, Pichet Somsapt. Evaluation of hypoglycemic properties and fertility effect of Piper sarmantosum Roxb. aqueous leaf extract in streptozotocin induced diabetic mice. ijp [Internet]. 2014 Sep. 30 [cited 2024 Jul. 15];6(3):448-54. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/358

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