Antiepileptic activity of leaves of Leucas aspera.


  • Ramalingam Ramani Department:Pharmaceutical Chemistry, Associate Professor, Swami Ramananda Tirtha Institute of Pharmaceutical Sciences India.
  • Bindu Madhavi Boddupalli Swami Ramananda Tirtha Institute of Pharmaceutical Sciences, Nalgonda, Telangana, India. 508004 India.
  • Ramya Miryala Swami Ramananda Tirtha Institute of Pharmaceutical Sciences, Nalgonda, Telangana, India. 508004 India.
  • Ravinder Nath Anisetti Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana, India. 500017 India.
  • Nagulu Malothu Swami Ramananda Tirtha Institute of Pharmaceutical Sciences, Nalgonda, Telangana, India. 508004 India.
  • Deepthi Balla University College of Science of Informatics, Mahatma Gandhi University, Nalgonda, Andhra Pradesh, India. 508001 India.


Leucas aspera, Malondialdehyde, Pentylenetetrazole


Leucas aspera (LA) is a plant that has been used in folk medicine to treat asthma, fever, skin diseases and has several pharmacological activities. The antiepileptic property of LA was not yet been studied. Aim: The present study was aimed to investigate the antiepileptic activity of ethanolic extract obtained from leaves of LA on pentylenetetrazole (PTZ) kindling seizures in mice. Method: The ethanolic extract 200mg/kg and 400mg/kg were evaluated for the antiepileptic activity against PTZ (40mg/kg IP) induced seizure method. Diazepam was used as the standard drug. Antiepileptic activity was evaluated by observing seizure intensity, motor coordination, depression and oxidative stress by malondialdehyde (MDA) content. Results: Treatment with extract was found to be in dose dependant manner with significant prolonged onset time, decreased duration and intensity of seizure when compared with vehicle treated group. Extract has even protected the animal from loss of motor coordination and depression. Conclusion: From the results of present study it can be concluded that, the ethanolic extract of leaves of LA protected the animals from seizure effect induced by PTZ and attenuated the oxidative stress induced by PTZ without producing loss of motor coordination and depression.


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How to Cite

Ramalingam Ramani, Bindu Madhavi Boddupalli, Ramya Miryala, Ravinder Nath Anisetti, Nagulu Malothu, Deepthi Balla. Antiepileptic activity of leaves of Leucas aspera. ijp [Internet]. 2014 Sep. 30 [cited 2024 Feb. 28];6(3):391-14. Available from:



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