A Plant Oxysterol as a regulator of glucose homeostasis


  • P. Muthuraman Associate Professor Dept. of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry-605014, India.
  • K. Srikumar Associate Professor Dept. of Biochemistry and Molecular Biology, School of Life Sciences, Pondicherry University, Puducherry-605014, India.


Insulin, glucose, hexokinase, protein, receptor


Background: Plant oxysterols like 28-homobrassinolide (HB) exhibit partial structural homology to oxycholesterols. HB’s effect in cell metabolism was therefore investigated using rat model. Results: Oral administration of HB to streptozotocin induced diabetic male albino wistar rats, reduced circulating glucose level to normal level. Serum insulin content was increased by HB treatment. HB elevated the hexokinase (HK) enzyme activity of liver in the experimental animal. Peroxidative damage of cellular lipids was reduced by HB based on quantitative estimates of malonyldialdehyde (MDA) and 4- hydroxy nonenol (4-HNE) content of erythrocyte samples. Conclusion: The antihyperglycemic and antioxidant potential of HB was presented


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How to Cite

P. Muthuraman, K. Srikumar. A Plant Oxysterol as a regulator of glucose homeostasis. ijp [Internet]. 2010 Jun. 30 [cited 2024 Jun. 21];2(2):139-46. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/30



Original Research Articles