A Comprehensive Ethno-Phyto-Pharmacological Review on Novel Indian Medicinal Plants Used In Polyherbal Formulations
Keywords:
Medicinal Plants, Ethanomedical Use, Phytochemistry, Pharmacological SereeningAbstract
Almost 15% out of the 20,000 medicinal plants in Indian sub continent has a tremendous potential and advantage in the emerging field of herbal medicines. Medicinal plants are the main sources of chemical substances with potential therapeutic effects. A lot of compounds were characterized from plants which are now using in the treatment of many diseases. Since ancient times, plants have been an exemplary source of medicine. Ayurveda and other Indian literature mentioned the use of plants in treatment of various human ailments. Medical plants play an important role in the management of different clinical problems especially in developing countries where resources are meager The present paper reviews the literature on recent ethno medicinal uses with pharmacological screeing of every plant part of different five medicinal plants, i.e Cassia Auriculata Linn, Cinnamomum tamala, Ficus benghalensis, Trichosynthes dioica and Mangifera indica and their phytochemical properties used for the treatment of various ailments in human civilization as well as used in folk medicine as a remedy. The name and parts of the plant studied, the spectrum of activity, and methods used are discussed in this review paper.
References
. Prakasha HM, Krishnappa M,
Krishnamurthy YL, Poornima SV. Folk
medicine of NR PuraTaluk in
Chikamaglur district of Karnatka.Indian
Journal of Traditional Knowledge 2010;
(1):55-60.
. World Health Organization. Guidelines
for the Assessment of Herbal Medicine
Programme on Traditional
Medicine.Doc. WHO/TRM/91.4.WHO,
Geneva, 2003.
. Biswas K, chattopadhyay I, Banerjee RK
& Bandyopadhyay U. Biological activities
and medicinal properties of neem
(Azadirachta indica). Curr sci. 2002;
:1336.
. Bandopadhyay U, Biswas K, Chatterjee
R, Bandopadyay D, chattopadhyay I,
Ganguly C K, Chakraborty T,
Bhattacharya K, & Banerjee RK.
Gastroprotective effect of
Neem(Azadirachta indica) bark extract:
possible involvement of H+-K+-ATPase
inhibition and scavenging of hydroxyl
radical. Life sci. 2002; 71: 2845.
. Grover JK, Yadav S, Vats V. Medicinal
plants of India with antidiabetic potential.
J Ethnopharmacol. 2002; 81:81-100.
. Edwards DM. The marketing of nontimber forest products from the
Himalayas: The Trade between East
Nepal and India. In: Rural Development
Forestry Network (Overseas
Development Institute, London) Paper.
; 15b:1-21
. S. T. Chang and S. S. Cheng.
Antitermitic activity of leaf essential oils
and components from Cinnamomum osmophleum. Journal of Agricultural and
Food Chemistry. 2002; 50(6):1389ă92.
. S. Nautiyal and H. Kaechele. Adverse
impacts of pasture abandonment in
Himalayan protected areas: testing the
efficiency of a natural
resourcenmanagement plan (NRMP).
Environmental Impact Assessment
Review. 2007; 27(2):109ă25.
. Gaur, R.D. Traditional dye yielding
plants of Uttarakhand, India. Natural
Products Radiance, 2008; 27(2): 154-65
. Chao LK, Hua K-F, Hsu H-Y, et al. Study
on the antiinflammatory activity of
essential oil from leaves of
Cinnamomum osmophloeum. J Agric
Food Chem. 2005; 53: 7274-8.
. Jayaprakasha GK, Rao LJ, Sakariah KK.
Volatile constituents from Cinnamomum
zeylanicum fruit stalks and their
antioxidant activities. J Agric Food
Chem. 2003; 51: 4344-8
. Nath SC, Baruah A, Hazarika AK.
Essential oils of leaves of Cinnamomum
Schaeffer members. Ind perfumer. 1999;
: 182-90
. Chanotiya CS, Yadav A.
Enantioenriched (3S)-(+)-Linalool in the
Leaf Oil of Cinnamomum tamala Nees et
Eberm. from Kumaon. J Essential Oil
Res. 2010: 22: 593
. Suresh Kumar, Sunil Sharma, Neeru
Vasudeva. Chemical compositions of
Cinnamomum tamala oil from two
different regions of India. Asian Paci J
Trop Dis.2012; S761- 4
. Mollenbeck S, Konig T, Schreier P, et al.
Chemical composition and analysis of
enantiomers of essential oils from
Madagascar. Flavour Fragrance J.1997
;12: 63-9
. J. Rema, N.K. Leela, B. Krishnamoorthy,
P.A. Mathew. Chemical composition of
Cinnamomum tamala essential oil- A
review. Journal of Medicinal and
Aromatic Plant Sciences. 2005; 27: 515-
. Roux GF, Perrier J, Forest E, Mouren
GM, Puigserver A, and Santimone M.
Screening of bark of Cinnamomum
tamala (Lauraceae) by using aamylase
inhibition assay for anti-diabetic activity.
Biochim Biophys Acta. 1998;1388: 10-20
. Usha Chakraborty, Hariswami Das.
Antidiabetic and Antioxidant Activities of
C.tamala Leaf Extracts in Stz-Treated
Diabetic Rats . G J Biotech Biochem.
; 5 (1):12-8.
. Shradha Bisht, S.S Sisodia. Assessment
of antidiabetic potential of cinnamomum
tamala leaves extract in streptozotocin
induced diabetic rats. Ind J Pharmacol.
; 43(5). 582-5.
. Rahul Gupta, Pramod Kumar Agnihotri,
Samta Johri And Anand Murari Saxena.
Hypoglycaemic Activity of Ethanol
Extract of Cinnamomum tamala Leaves
in Normal and Streptozotocin Diabetic
Rats. Iran J Pharmacol & Therapeutics.
; 8:17-21.
. Palanisamy P, K.R. Srinath, D.
Yoganand Kumar, Pooja Chowdary C.
Evaluation of antioxydent and ant
diabetic activity of cinnamomum tamala
Linn leaves in Streptozotocin induced
diabetic rats. Int Res J Pharm. 2011; 2
(12): 157-62.
. Prabuseenivasan S, Jayakumar M,
Ignacimuthu S. In vitro antibacterial
activity of some plant essential oils.
BMC Compl & Alter Med.2006; 6: 39
. Jamiuddin Ahmed, Nasrin Sultana, Syed
M. R. Dewan, Mohammad N Amin, S. M.
Naim Uddin. Determination of Chemical
Groups and Investigation of
Anthelmintic, Cytotoxic, and
Antibacterial Activities of Leaves of
Cinnamomum Tamala (Family:
Lauraceae). Int J Pharmamedix Ind.
; 1(2): 222-32.
. Osawa T and Namaki M. A novel type
antioxidant isolated from leaf wax of
Eucalyptus leaves. Agric Biol Chem.
; 45: 735-9.
. Miller NJ and Rice- Evans CA. Factors
affecting the antioxidant activity
determined by ABTS+ radical cation
assay. Free Radic Res. 1997; 26: 195-9
. Durre Shahwar, Shafiq-ur-Rehman,
Naeem Ahmad. Antioxidant activities of
the selected plants from the family
Euphorbiaceae, Lauraceae, Malvaceae
and Balsaminaceae. Afri J Biotech.2010;
(7): 1086-96
. Devi SL, Kannappan S, Anuradha CV.
Evaluation of in vitro antioxidant activity
of Indian bay leaf, Cinnamomum tamala
(Buch. -Ham.) T. Nees & Eberm using
rat brain synaptosomes as model
system. Ind J Exp Biol. 2007; 45(9):778-
. Lima ZP, Severi JA, Pellizzon CH, Brito
AR, Solis PN.Gastroprotective activity of
Cinnamomum tamala leaves on
experimental gastric ulcers in rats. J.
Ethnopharmacol. 2010; 128: 537-40
. Vardar Unlu G, Candan, Sokmen A,
Domez Eand Tepe B. Antimicrobial
activity of essential oil from C. tamala
(Lauraceae). J Agric Food Chem.2003;
: 63-7
. Manindra Mohan, S. Zafar Haider,
Akash Sharma, Richa Seth and Mithun
Sharma. Antimicrobial activity and
composition of the volatiles of
Cinnamomum tamala Nees. and
Murraya koenigii (L.) Spreng. from
Uttarakhand (India). Asian Paci J Trop
Dis. 2012; S324-7
. Hemayet Hossain, Md. Sariful Islam
Howlader, Shubhra Kanti Dey, Arpona
Hira, et al,. Evaluation of antiinflammatory activity of cinnamomum
tamala (buch.-ham.) Leaves growing in
bangladesh. Int J pharmaschol. 2012; 1
(2): 114-21
. Manmeet S Saluja, B Sangameswaran,
Ajay Sharma. Cytotoxic activity of
cinnamomum tamala linn. Against
ehrlich ascites Carcinoma (eac) in mice.
T. Ph. Res. 2010; 3: 232-42.
. Gambhire MN, Juvekar AR, Wankhede
SS. Anti-inflammatory activity of
aqueous extract of Cinnamomum tamala
leaves by in vivo and in vitro methods. J
Ph Res. 2009; (2) 9: 1521- 4.
. Thamizhselvam N, Soumya S,
Sanjayakumar YR, Salinichandran K,
Venugopalan TN, Jaya N. AntiInflammatory, Analgesic And Antipyretic
Activity Of Methanolic Extract Of
Cinnamomum Tamala (Nees) In
Experimental Animal Models. Int J
Bioas, 2012; 01 (09): 26ă9.
. G.V. Manjunatha Reddy, R. Girish
GKVK, M. S. Uma, N. Srinivas.
Acaricidal activity of aqueous extracts
from leaves and bark of cinnamomum
and jatropha against two spotted spider
mite, Tetranychus urticae Koch.
Karnataka. J. Agric. Sci. 2009; 22(3) :
-5
. Ritu Singh, Amit Kumar Singh,
Akanksha Soam, Sushil Kumar Shahi.
Antifungal screening of various spice
extracts on azole resistant strains of
Candida. Int J Curr Disc and innov.
; 2(1): 46-52
. Bhawana Srivastava, Anand Sagar, N.
K. Dubey. Evaluation of Cinnamomum
tamala Oil and Its Phenylpropanoid
Eugenol for Their Antifungal and
Antiaflatoxigenic Activity. Food
Analytical Methods. 2011; 4 (3): 347-56
. Varsha Dhulasavant, Shubhangi Shinde,
Mangesh Pawar and N.S. Naikwade
Antihyperlipidemic activity of
Cinnamomum tamala Nees. on high
cholesterol diet induced hyperlipidemia.
Int J Ph & Life Sci. 2011; 2(1):506-10
. Md. Hemayet Hossain, Md. Sariful Islam
Howlader, Shubhra Kanti Dey et al,.
Evaluation of Antidiarrhoeal,
Antimicrobial and Cytotoxic Activities of
Cinnamomum Tamala Leaves from
Bangladesh. Int J Pharm. 2012; 2(4):
-6.
. Chandana Venkateswara Rao,
Madhavan Vijayakumar, K. Sairam,
Vikas Kumar. Antidiarrhoeal activity of
the standardised extract of
Cinnamomum tamala in experimental
rats. J Nat Med. 2008; 62 (4): 396-402
. Rao CV, Vijayakumar M, Sairam K,
Kumar V. Antidiarrhoeal activity of the
standardised extract of Cinnamomum
tamala in experimental rats. J Nat Med.
; 4(62): 396-402.
. Al-Mamun R, Hamid A, Islam MK,
Chowdhury JA and Zafrul Azam ATM.
Lipid Lowering Activity and Free Radical
Scavenging Effect of Cinnamomum
tamala (Fam: Lauraceae). Int J Nat Sci.
; 1(4):93-6
. Eswaran MB, Surendran S, Vijayakumar
M, Ojha SK, Rawat AKS, Rao CV.
Gastroprotective activity of
Cinnamomum tamala leaves on
experimental gastric ulcers in rats. J
Ethnopharmacol. 2010; 128: 537-40.
. Siva, R. and K.V. Krishnamurthy.
Isozyme diversity in Cassia auriculata L,
Afri J Biotechnol. 2005; 4: 772-5.
. SG Joshi, Cesalpinaceae- Cassia
auriculata, Textbook of Medicinal Plants,
third ed. India Book House, Bangalore,
. KV Ratnam, RRV Raju, Ind J Trad
Knowledge. 2005; 4: 267-70.
. GM Jeeva, S Jeeva, C Kingston, Ind J
Trad Knowledge. 2007; 6: 498-501.
. C Kingston, S Jeeva, S Kiruba, BP
Mishra, D Kannan, Ind J Trad
Knowledge. 2009; 8: 196-200.
. KV Ratnam, RRV Raju, Ind J Trad
Knowledge. 2008; 7: 436-7.
. S Nagnur, G Channal, N Channamma,
Ind J Trad Knowledge. 2009; 8:577-80.
. S Ganesan, S Ponnuchamy, S Kesavan,
A Selevaraj. Ind J Trad Knowledge.
; 8:154-200.
. C Muthu, M Ayyanar, M Raja, M
Ignacimuthu. J Ethnobiology and
Ethnomedicine. 2006; 2: 1-10.
. S Ganesan, M Chandhirasekaran, A
Selevaraj, Ind J Trad Knowledge. 2008;
: 347-54.
. BS, Sandhya, W Thomus, Isabel, R
Shenbagarathai. Afri J Trad, Compl,
and Alt Med. 2006; 3:101-14.
. K Rajendran, P Balaji, MJ Basu, Ind J
Trad Knowledge. 2008; 7: 417-20.
. Nageswara Rao, Mahesh Kumar P, VS
Dhandapani, Toshimitsu Hayashi.
Constituents of Cassia auriculata,
Fitoterapia.2000; 71: 82-3.
. A. Anandan, R. Eswaran, A.Doss, G.
Sangeetha and S. P. Anand. Chemical
Compounds Investigation of Cassia
auriculata Leaves ă APotential Folklore
Medicinal Plant. Bulletin of Environment,
Pharmacol & Life Sci. 2011; 1(1): 20-3.
. J. Yesu Raj, M. Paul John Peter, V. Joy.
Chemical compounds investigation of
Cassia auriculata seeds: A potential
folklore medicinal plant. Asian J Plant
Sci and Res. 2012; 2 (2):187-92
. Juan-Badaturuge M, Habtemariam S,
Thomas MJK. Antioxidant compounds
from a South Asian beverage and
medicinal plant, Cassia auriculata. Food
Chem.2011; 125: 221ă5.
. L Pari, M Latha Effect of Cassia
Auriculata Flowers on Blood Sugar
Levels, Serum and Tissue Lipids in
Streptozotocin Diabetic Rats. Singapore
Med J. 2002; 43(12) : 617-21
. Mahendra Shiradkarg, Pawankumar and
kapil shah. Pharmacological Evaluation
of Cassia Auriculata Bark Extract. Int J
Pharma and Bio Sci. 2011; 2 (1): 758-66
. Jeeva Jothi Dhanasekaran ; Mathangi
Ganapathy. Hepatoprotective Effect of
Cassia auriculata L. Leaf Extract on
Carbon Tetrachloride Intoxicated Liver
Damage in Wister Abino rats. Asian J
Biochem. 2011; 6 (1):104-12
. S. Maneemegalai and T. Naveen.
Evaluation of Antibacterial Activity of
Flower Extracts of Cassia auriculata
L.Ethnobotanical Leaflets. 2010; 14:
- 92
. C. Anushia, P. Sampathkumar and L.
Ramkumar. Antibacterial and
Antioxidant Activities in Cassia
auriculata. Global J Pharmacol. 2009; 3
(3): 127-30
. Gaurav M. Doshi, Supriya S. Shidhaye,
Gayatri V. Aggarwal, Preeja P. Pillai.
Antibacterial potential of Cassia
auriculata flowers. J. Microbiol. Biotech.
Res., 2011; 1 (3): 15-9.
. Vedavathy, S. and Rao, K.N. Antipyretic
activity of six indigenous medicinal
plants of Tirumala hills, J
Ethanopharmacol. 1991;33: 193-6.
. Kumaran, A., Joel Karunakaran, R.
Antioxidant activity of Cassia auriculata
flowers, Fitoterapia. 2007;78: 46-7
. PS Kumar, S Sucheta, VS Deepa, P
Selvamani, S Latha., Antioxidant activity
in some selected Indian medicinal
plants. Afri J Biotech. 2008; 7(12).
. Satish B. Kosalge, Ravindra A. Fursule.,
Investigation of anthelmintic potential of
some plants claimed by tribals of
satpuda hills. Int J Pharm Tech
Res.2009;1(1): 68-72
. P. Salvekar. Anthelmintic activity of
Cassia auriculata L. extracts-In vitro
study. Scholars Research Library J. Nat.
Prod. Plant Resour. 2011; 1(2): 62-6
. Sushma Kainsa, Praveen Kumar,
Randhir Singh Dahiya. Investigation of in
vitro anthelmintic activity of Cassia
auriculata leaves. J. Nat. Prod. Plant
Resour.2012; 2 (4):460-4.
. Senthil Kumar, Rajagopal Ponmozhi,
Manickam Viswanathan ,Periyasamy
Nalini Namasivayam Activity of Cassia
auriculata leaf extract in rats with
alcoholic liverinjury. T J Nutri
Biochem.2003; 14(8): 452ă8.
. Ahmed M, Rao SA, Thayyil HA, Ahemad
RS, Abid M, Ibrahim M. antiulcer activity
of leaf extract of Cassia auriculata.
Pharmacog J. 2010;2(16):48-52
. H. M. Suresh, B. C. Hatapakki, S. I.
Shivakumar, C. S. Hallikeri, B. M.
Swamy, V. K. Chandur. J Nat Rem.
; 7(1): 150 ă 4
. V.V. Shivrajan. Ayurvedic drugs and
their Plant sources. Oxford and IBH
Publishing Company Pvt. Ltd. New
Delhi; 2002.p.333
. Prajapati, Purohit, Sharma and Kumar.
A handbook of Indian medicinal plants a
complete source book; 2005. p. 237
. A. Chatterjee. The treaties of Indian
medicinal plants: Vol.I; 1997. P. 39
. Chopra R. N., Chopra I.C. Handa K.L.
and Kapur L.D. Indigenous drugs of
India, U.N.Dhur and sons Pvt. Ltd.
Calcutta; 1958. p.673- 5
. Medicinal plants of India, ICMR, New
Delhi, vol.I; 1956. p.415-6.
. C.P. Khare. Encyclopedia of Indian
Medicinal Plants. Springer publication;
P. 216-7
. Rimi Shukla, Shweta Gupta , J.K.
Gambhir , K.M. Prabhu , P.S. Murthy.
Antioxidant effect of aqueous extract of
the bark of Ficus bengalensis in
hypercholesterolaemic rabbits. J
Ethnopharmacol. 2004; 92: 47ă51
. Subramanian PM, Misra GS. Chemical
constituents of Ficus bengalensis (Part
II). Pol J Pharmacol Pharm. 1978;
(4):559-62
. Sheeja Cherian, Vinod Kumar, R. and
Augusti, K.T. (1992) Antidiabetic effect
of glycoside from Pelargonidin isolated
from the bark Ficus bengalensis Linn.
Ind. J. Biochem. Biophys. 1992;29: 380 -
. The Wealth of India, Volume-(F-G). In: A
Dictionary of Indian Raw Materials and
industrial products. Vol. 4. New Delhi:
Council of Scientific and Industrial
Research;1999. p. 24-6
. Kumar RV, Augusti KT, Insulin sparing
action of a leucocynidin derivative
isolated from Ficus bengalensis Linn.
Ind J Biochem and Biophy. 1994; 31:73-
. Daniel RS, Devi KS, Augusti KT
Mechanism of action of Antiatherogenic
and related effects of Ficus bengalensis
Linn. Flavonoids in experimental
animals. Ind J Exp Bio. 2003; 41:296-
. Geetha BS, Mathew BC, Augusti KT,
Hypoglycemic effects of
Leucodelphinidin derivative isolated from
Ficus bengalensis Ind J Physiol.
Pharmacol. 1994; 38(3):220.
. Augusti KT Hypoglycemic action of
bengalenoside: Aglucoside isolated from
Ficus Bengalensis Linn, in normal and
Alloxan diabetic rabbits. Ind J Physiol
Pharmacol. 1975; 19:218-20
. Augusti K T, Daniel RS, Cherian S,
Sheela CG,Nair CR Effect of
Leucopelargonin derivative from Ficus
bengalensis Linn on diabetic dogs. Ind J
Med Res. 1994; 82-6
. Cherian S, Sheela and Augusti K T
Insulin sparing action of
Leucopelargonin derivative solated from
Ficus bengalensis Linn. Ind J Exp Bio.
;33:608-11.
. Vikas VP, Vijay RP. Ficus bengalensis.
An Overview. Int. J. Pharm. Biol. Sci.
; 1(2): 1-11.
. Mohammad A, Kamran JN, Javed A,
Showkat RM. Three new esters from the
stem bark of Ficus bengalensis Linn. J.
Pharm. Res. 2010; 3(2): 352-5.
. A.Chatterjee. The treaties of Indian
medicinal plants. Vol.I; 1997. p. 39.
. Daniel, R.S., Mathew, B.C., Devi, K.S.,
Augusti, K.T. Antioxidant effect of two
flavonoids from the bark of Ficus
bengalensis Linn. in hyperlipidemic rats.
Ind J Exp Bio.1998; 36: 902ă6.
. Mousa O, Vuorela P, Kiviranta J, Wahab
SA, Hiltohen R, Vuorela H. Bioactivity of
certain Egyptian Ficus species. J
Ethnopharmacol. 1994; 41:71- 6.
. Anurag S, Moni K, Jagannadham MV.
Bengalensin, a Highly Stable Serine
Protease from the Latex of Medicinal
Plant Ficus bengalensis. J. Agric. Food
Chem. 2009; 57(23): 11120ă6.
. Aswar M, Aswar U, Watkar B, Vyas M,
Wagh A., Gujar KN Anthelmintic activity
of Ficus bengalensis Int J Green Ph.
;2:3.
. Patil V.V., Pimprikar R.B., Patil V.R.
Pharmacognostical Studies and
Evaluation of Anti-inflammatory Activity
of Ficus bengalensis Linn. JYP 2009;
(1)
. Vishnu N Thakare, Anupama A suralkar,
Avinash D Deshpande, Suresh R Naik.
Stem bark extraction of Ficus
bengalensis linn for anti inflammatory
and analgesic activity in animal models.
Ind J Exp Bio. 2010; 48:39-45.
. Vikas V. Patil, Bhangale S.C., Narkhede
S.B., Jawle N. M., Patil V. R. Analgesic
and Antipyretic Activities of Ficus
Bengalensis Bark. Int J Phar Res.2010;
(2).
. DJ Taur, SA Nirmal ,RY Patil, MD
Kharya. Antis tress and ant allergic
effects of Ficus bengalensis bark in
asthma. Nat Prod Res.
;21,14:1266-70.
. Pulok K. Mukherjee, Kakali Saha, T.
Murugesan, S.C. Mandal, M. Pal, B.P.
Saha. Screening of anti-diarrhoeal
profile of some plant extracts of a
specific region of West Bengal. Ind J
Ethnopharmacol. 1998;60: 85ă9.
. Mahalingam G, Krishnan K. Antidiabetic
and amelioferative potential of Ficus
bengalensis bark extract in
streptozotocin induced diabetic rats. Ind
J Biochem. 2008;23(4):394-400.
. Joglekar, J.C., Shrotri, D.S., Aiman, R.
and Balwani, J.H. A study on Ficus
bengalensis Lin. J. Ind. Med. Assoc.
: 40: 11-12.
. Vohra, S.B. and Parasar, G.C.
Antidiabetic studies on Ficus
bengalensis Linn. Ind. J. Pharmacy.
; 32: 68-9.
. Babu, B.V. Studies on Hypoglycemic
action of Ficus bengalensis (PhD
Thesis, Delhi University, Delhi).1985
. Kumar R.V., Augusti K.T. Antidiabetic
effect of a leucocynidin derivative
isolated from the bark of Ficus
bengalensis Linn. Ind J Biochem
Biophys.1989; 26 (6):400-4.
. Cherian S, Augusti K.T. To study the
Antidiabetic effects of a glycoside of
leucopelargonidin isolated from Ficus
bengalensis Linn. Ind J Exp Biol. 1993;
(1):26- 9.
. Geetha BS, Mathew BC, Augusti KT,
Hypoglycemic effects of
Leucodelphinidin derivative isolated from
Ficus bengalensis Ind J Physiol.
Pharmacol.1994; 38(3):220.
. Shukla, R., Anand, K., Prabhu, K.M. and
Murthy, P.S. Hypoglycemic effect of the
water extract of Ficus bengalensis in
alloxan recovered mildly diabetic and
severely diabetic rabbits. International.
J. Dia. Dev. Countries: 14, 78-81,
(1994).
. Shukla, R. Investigations on the
hypoglycemic activity of Ficus
bengalensis, PhD Thesis, Delhi
University, Delhi.1995.
. Agrawal V. Chauhan BM. A study on
composition and Hypolipidemic effect of
dietary fibre from some plant foods
.Plant foods hum Nutr. 1988; 38(2):189-
. Gabhe S.Y., P.A. Tatke, T.A. Khan
Evaluation of the Immunomodulatory
activity of the methanol extract of Ficus
bengalensis roots in rats. Ind J
Pharmacol. 2006; 38(4):271-5.
. Biswas TK, Mukherjee B. Plant
medicines of Indian origin for wound
healing activity: a review. Int J Low
Extreme Wounds. 2003;2(1): 25- 39.
. Ayyanar M, Ignacimuthu S. Herbal
Medicines for wound healing among
tribal people in Southern India:
Ethnobotanical and Scientific Evidences.
Int. J. Appl. Res. Nat. Prod. 2009; 2(3):
-42.
. Vipin K. Garg and Sarvesh K.Paliwal. J
adv Pharm Tech & Res. 2011; 2(2): 110-
. Nidhiya SR, Pai KSR, Rao CM. Growth
promoting potential of Ficus bengalensis
root extracts in immature female rats. J.
Pharm. Biol.2009; 47(4): 268-73.
. Ross IA. Medicinal Plants of the world,
Chemical constituents, Chemical
constituents. Traditional and Modern
Medicinal Uses, Humana Press, Totowa.
; p. 197-205
. Anonymous. „The Wealth of India- Raw
materials‰. Vol. VI:L-M; 1962. P. 281.
. Anonymous, „The Wealth of India- Raw
materials‰. Vol VI:L-M; 2005. P. 280.
. Muruganandan.S, Scrinivasan.K,
Gupta.S, Gupta.P.K and Lal.J. Effect of
mangiferin on hyperglycemia and
atherogenicity in streptazotocin diabetic
rats. J ethnopharm. 2005; 97: 497-501.
. Badmus.J.A, Adedosu.T.U, Fatoki.J.O,
Adegbite.V.S, Adaramoye.O.A,
Odunola.O.A. Lipid peroxidation
inhibition and antiradical activities of
some leaf fractions of Mangifera indica.
Acta Pol Pharm. 2011; 68(1) :23-9.
. Enikuomehin.O.A, Ikotun.T, Ekpo.E.J.
Evaluation of ash from some tropical
plants of Nigeria for the control of
sclerotium rolfsii sacc. On wheat
(Triticum aestivum L.). Mycopathologia.
;142(2):81-7.
. Zhu.X.M, Song.J.X, Huang.Z.Z,
Whu.Y.M and Yu.M.J. Antiviral activity of
Mangiferin against herpes simplex virus
type 2 in vitro.
ZhongguoYaoliXuebao.193; 14: 452-4.
. Godfrey S,Bbosa, Aloysius Lubega,
Nathan Musisi, David B, Kyegombe,
Paul Waako, Jasper Ogwal-Okeng,
OlwaOdyek. The activity of Mangifera
indica L. leaf extracts against the
tetanus causing bacterium, clostridium
tetani. Afri J of Ecology. 2007; 45:54-8.
. Ngozi.O Awa-Imaga. Possible antitrypanosomal effect of aqueous leaf
extracts of Mangifera indica on plasma
proteins of Trypanosomacongolenseinfected rats. J pharmacog and
phytotherapy.2011; 3(8):137-40.
. Scartezzini P, Speroni E. Review on
some plants of Indian traditional
medicine with antioxidant activity. J
Ethnopharmacol. 2000;71:23ă43.
. Anjaneyulu V, Babu JS, Connolly JD.
-Hydroxymangiferonic Acid from
Mangifera-Indica. Phytochem. 1994; 35:
-3.
. Selles AJN, Castro HTV, Aguero-Aguero
J, Gonzalez-Gonzalez J, Naddeo F, De
Simone F, Rastrelli L. Isolation and
quantitative analysis of phenolic
antioxidants, free sugars, and polyols
from mango (Mangifera indica L.) stem
bark aqueous decoction used in Cuba
as a nutritional supplement. J Agri and
Food Chem. 2002; 50: 762-6.
. Khan MN, Nizami SS, Khan MA, Ahmed
Z. New saponins from Mangifera indica.
J Nat Prod. 1993 ; 56: 767-70.
. Anjaneyulu V, Satyanarayana P,
Viswanadham KN, Jyothi VG, Rao KN,
Radhika P. Triterpenoids from Mangifera
indica. Phytoche. 1999; 50: 1229-36.
. Anjaneyulu V, Prasad KH, Ravi K,
Connolly JD. Triterpenoids from
Mangifera-Indica. Phytochem. 1985 ; 24:
-67.
. Anjaneyulu V, Ravi K, Prasad KH,
Connolly JD. Triterpenoids from
Mangifera-Indica. Phytochem. 1989 ; 28:
-7.
. Shibahara A, Yamamoto K, Shinkai K,
Nakayama T, Kajimoto G. Cis-9, cis-15-
octadecadienoic acid:a novel fatty acid
found in higher plants. Biochimi Biophy
Acta. 1993;1170:245ă52.
. Bandyopadhyay C, Gholap AS,
Mamdapur VR. Characterization of
Alkenylresorcinol in Mango (MangiferaIndica L) Latex. J Agri and Food Chem.
; 33: 377-9.
. Khan MA, Khan MN. Alkyl gallates of
flowers of Mangifera Indica. Fitoterapia.
;60:284.
. V. Anjaneyulu , P.Radhika. The
terpenoids and steroids from Mnagifera
Indica Linn. Ind J chem. 2000;
(B):883-93
. Knödler M, Berardini N, Kammerer DR,
Carle R, Schieber A. Characterization of
major and minor alk(en)ylresorcinols
from mango (Mangifera Indica L.) peels
by high-performance liquid
chromatography/atmospheric pressure
chemical ionization mass spectrometry.
Rapid Commun Mass Spectrom.
;21:945ă51.
. Martinez G, Delgado R, Perez G,
Garrido G, Nunez Selles AJ, Leon OS.
Evaluation of the in-vitro antioxidant
activity of Mangifera indica L: Extract
(Vimang). Phytother Res. 2000;14:424ă
. Pardo-Andreu GL, Sanchez-Baldoquín
C, Avila-González R, Yamamoto ET,
Revilla A, Uyemura SA, et al. Interaction
of Vimang (Mangifera indica L.extract)
with Fe(III) improves its antioxidant and
cytoprotecting activity. Pharmacol Res.
; 54:389ă95.
. Rocha Ribeiro SM, Queiroz JH, Lopes
Ribeiro ME, Campos FM, Pinheiro
Santana HM. Antioxidant in mango
(Mangifera indica L.) pulp. Plant Foods
Hum Nutr. 2007;62:13ă7.
. Gabino G, Deyarina G, Cheyla R,
Nunez-Selles AJ, Rene D. Scavenger
effect of a mango (Mangifera indica L.)
food supplement's active ingredient on
free radicals produced by human
polymorphonuclear cells and
hypoxanthineăxanthine oxidase
chemiluminescence systems. Food
Chem. 2008;107:1008ă14.
. Pardo Andreu G, Delgado R, Velho J,
Inada NM, Curti C, Vercesi AE.
Mangifera Indica L.extract (Vimang)
inhibits Fe2+- citrate-induced
lipoperoxidation in isolated rat liver
mitochondria. Pharmacol Res.
;51:427ă35.
. Sharma SR, Dwivedi SK, Swarup D.
Hypoglycemic potential of Mangifera
indica leaves in rats. Int J Pharmaco.
;35:130.
. Aderibigbe AO, Emudianughe TS, Lawal
BA. Antihyperglycaemic effect of
Mangifera indica in rat. Phytother Res.
;13:504ă7.
. Aderibigbe AO, Emudianughe TS, Lawal
BA. Evaluation of the antidiabetic action
of Mangifera indica in mice. Phytother
Res. 2001;15:456ă8.
. Perpétuo GF, Salgado JM. Effect of
mango (Mangifera indica, L.) ingestion
on blood glucose levels of normal and
diabetic rats. J Plant Foods Hum Nutr.
;58:1ă12.
. Ojewole JA. Antiinflammatory, analgesic
and hypoglycemic effects of Mangifera
indica Linn.(Anacardiaceae) stem-bark
aqueous extract. Methods Find Exp Clin
Pharmacol. 2005;27:547ă54.
. Amrita B, Liakot A, Masfida A, Begum R.
Studies on the antidiabetic effects of
Mangifera indica stem-barks and leaves
on nondiabetic, type 1 and type 2
diabetic model rats. Bangladesh J
Pharmacol. 2009;4:110ă4.
. Muruganandan S, Scrinivasan K, Gupta
S, Gupta PK, Lal J. Effect of mangiferin
on hyperglycemia and atherogenicity in
streptozotocin diabetic rats. J
Ethnopharmacol. 2005;97:497ă501.
. Rolo AP, Palmeira CM. Diabetes and
mitochondrial function: Role of
hyperglycemia and oxidative stress.
Toxicol Appl Pharmacol. 2006;212:167ă
. Zhu XM, Song JX, Huang ZZ, Whu YM,
Yu MJ. Antiviral activity of mangiferin
against herpes simplex virus type 2 in
vitro. Zhongguo Yao Li Xue Bao.
;14:452ă4.
. Zheng MS, Lu ZY. Antiviral effect of
mangiferin and isomangiferin on herpes
simplex virus. Chin Med J.
;103:160ă5.
. Guha S, Ghosal S, Chattopadyay U.
Antitumor, immunomodulatory and antiHIV effect of mangiferin: A naturally
occurring glucosylxanthone.
Chemotherapy. 1996;42:443ă51.
. Garcia D, Escalante M, Delgado R,
Ubeira FM, Leiro J. Anthelminthic and
antiallergic activities of Mangifera indica
L.stem bark components Vimang and
mangiferin. Phytother Res.
;17:1203ă8.
. Rivera DG, Balmaseda IH, Leon AA,
Hernandez BC, Montiel LM, Garrido GG,
et al. Anti-allergic properties of
Mangifera indica L.extract (Vimang) and
contribution of its glucosylxanthone
mangiferin. J Pharm Pharmacol.
;58:385ă92.
. Muanza DN, Euler KL, Williams L,
Newman DJ. Screening for antitumor
and anti-HIV activities of nine medicinal
plants from Zaire. Int J Pharmacol.
;33:98.
. Aswal BS, Bhakuni DS, Goel AK, Kar K,
Mehrota BN, Mukhrjee KC. Screening of
Indian plants for biological activity: Part
X. Indian J Exp Biol. 1984;22:312ă32.
. Peng ZG, Luo J, Xia LH, Chen Y, Song
S. CML cell line K562 cell apoptosis
induced by mangiferin. Zhongguo
Shiyan Xue Ye Xue Za Zhi.
;12:590ă4.
. Yoshimi N, Matsunaga K, Katayama M,
Yamada Y, Kuno T, Qiao Z, et al. The
inhibitory effects of mangiferin: A
naturally occuring glucosylxanthone, in
bowel carcinogenesis of male F344 rats.
Cancer Lett. 2001;163:163ă70.
. Doughari, J. H. and Manzara, S. In vitro
antibacterial activity of crude leaf
extracts of Mangifera indica Linn. Afri J
Microbio Res. 2008;2:67-72.
. K.P. Latha, M. S. Latha, H. M. Vagdevi,
S. B. Virupaxappa. Anti inflammatory
activity of Mangifera indica L. Var.
Rasapuri Root extracts. J Chem and
Pharm Res.2012; 4(1), 333-6.
. Saruth Nithitanakool, Pimolpan
Pithayanukul , Rapepol Bavovada.
Antioxidant and Hepatoprotective
Activities of Thai Mango Seed Kernel
Extract. Planta Med. 2009; 75(10): 1118-
. Jagetia GC, Baliga MS. Radioprotection
by mangiferin in DBAxC57BL mice: a
preliminary study. Phytomedicine.2005;
: 209-15
. Yoshikawa M, Shimoda H, Nishida N,
Takada M, Matsuda H. Salacia reticulata
and its polyphenolic constituents with
lipase inhibitory and lipolytic activities
have mild antiobesity effects in rats. T J
Nutri. 2002; 132: 1819-24
. Kirtikar KR, Basu BD. Indian medicinal
plant. 2nd ed. Dehradun: Oriental
enterprises; 2001. p. 1543ă4.
. Singh BP, Wayne F. Whitehead Pointed
gourd: Potential for temperate climates.
J Janick. 1999; 118:27ă35.
. Nadkarni AK. Indian Materia Medica. 3rd
ed. Mumbai: Popular prakashan Pvt.
Ltd; 1982. p. 1236ă7.
. Khare CP. Encyclopedia of Indian
medicinal plants. Berlin, Heidelberg;
New York: Springer-Verlag; 2004. p.
ă8.
. Chopra RN, Nayar SL, Chopra IC,
Glossary of Indian Medicinal plants,
CSIR, New Delhi, 2002, p.340.
. Kongton S, Chemical study of bioactive
constituents from Trichosanthes
cucumerina root and fruit juice, Mahidol
University, 2003. P.80-5.
. Ali N, Mohammed Sultan, Kenoth R,
Swamy MJ, Purification,
physicochemical characterization,
saccharide specificity, and chemical
modification of a Gal/GalNAc specific
lectin from the seeds of Trichosanthes
dioica. Arc of Biochem and Biophy.
; 432: 212ă21.
. Chandrasekhar B, Mukherjee B,
Mukherjee SK, Blood sugar lowering
effect of Trichosanthes dioica Roxb. in
experimental rat models. Int J Cru Drug
Res. 1988; 26: 102ă6.
. Rai PK, Jaiswal D, Singh RK, Gupta RK,
Watal G. Glycemic Properties of
Trichosanthes dioica leaves. Pharm
bio.2008; 46(12): 894-9.
. Rai DK, Rai PK, Jaiswal D, Sharma B,
Watal G. Effect of water extract of
Trichosanthes dioica fruits in
streptozotocin induced diabetic rats. Ind
J Clinical Biochem. 2008; 23 (4): 387-90.
. Ghaisas MM, Tanwar MB, Ninave PB,
Navghare VV, Deshpande T,
Hepatoprotective activity of aqueous &
ethanolic extract of T. dioica in ferrous
sulphate induced liver injury.
Pharmacologyonline.2008; 3: 127-35.
. Sharmila BG, Kumar G, Rajasekhara
PM. Cholesterol-lowering activity of the
aqueous fruit extract of Trichosanthes
dioica in normal and streptozotocin
diabetic rats. J Clin Dia Res.2007; 1(4):
-69.
. Sharma G, Pant MC. Influence of
alcoholic extract of whole fruit of T.
dioica, on blood sugar, serum lipids,
lipoproteins & faecal sterols in normal
albino rabbits. Ind J clinical biochem.
; 1: 53-6.
. Fulzule SV, Satturwar D, Joshi SB,
Studies on anti-inflammatory activity of a
poly herbal formulation- Jatydi Ghrita.
Ind drugs.2001; 39(1): 42-4.
. Hariti M, Rathee PS. Antifungal activity
of the unsaponifiable fraction of the fixed
oil of Trichosanthes seeds. Asian J
chem.. 1996; 8(1): 180-2.
. Hariti M, Rathee PS. Antibacterial
activity of the unsaponifiable fraction of
the fixed oil of Trichosanthes seeds.
Asian J Chem1995; 7 (4): 909-11.
. Rai PK, Mehta S, Gupta RK, Watal G. A
Novel Antimicrobial Agents
Trichosanthes dioica. Int J Pharma and
Bio Sci.2010; 1(3): 1-9.
. Shivhare Y, Singh P, Rajak H, Patil UK,
Pawar RS. Antioxidant potential of
Trichosanthes dioica Roxb (fruits).
Phcog J.2010; 2(6): 107-11.
. Shivhare Y, Singh P and Patil UK,
Healing Potential of Trichosanthes
dioica Roxb. On Burn Wounds. Res J
Pharmacol and pharmacodyn. 2010;
(2): 168-71.
. Singh KP, Singh RH, Clinical
investigation of importance of T. dioica.
J Res Ayurveda, siddha. 1985;6(2):
- 40.