Preventive effect of Polyherbal mixture against Rifampicin and Pylorus ligation-Induced Gastric Ulcers and liver necrosis in Rats
Keywords:
polyherbal mixture, liver toxicity, ulcer index, Antitubercular, hepatoregenrativeAbstract
Antitubercular drug is produced hepatotoxicity is major drawback of an effective treatment of treatment of tuberculosis. In this paper we review the incidence, pathology and clinical features of antituberculosis drug-induced hepatotoxicity, discuss the metabolism and mechanisms of toxicity of Rifampicin, and describe risk factors and management of antituberculosis drug induced hepatotoxicity, the antiulcer activity was assessed by determining and comparing the ulcer index in the test drug groups with that of the vehicle control and standard Omeprazole. In case of pylorus ligation induced ulcers, the polyherbal mixture showed significant reduction of ulcers in a dose dependent manner. The parameters taken to assess antiulcer activity were % inhibition ulcer index. The results indicated that polyherbal mixture significantly (p<0.001) decreased the % inhibition ulcer index as well as hepatoregenrative action.
References
. Alma Tostmann, Antituberculosis druginduced hepatotoxicity, concise up-todate review, Journal of Gastroenterology
and Hepatology, 2008; 23: 192ă202.
. Yadav Uprety, Hugo Asselin, Emmanuel
K Boon, Saroj Yadav, Indigenous use
and bio-efficacy of medicinal plants in
the Rasuwa District, Central Nepal
Journal of Ethnobiology and
Ethnomedicine,3, 2010, 6:3.
. Subbia h. Arunachalam, Central
Electrochemical Research Institute,
Karai kudi, India.
. Mariamawit Yonathan, Kaleab Asre,
Ashenafi Assefa and Franz Bucar In vivo
anti-inflammatory and anti-nociceptive
activities of Cheilanthes farinose, 108(3):
, 462-70.
. Rasika Dnyandeo Bhalke, Aboli Suresh
Girme , in-vitro anthelmintic and
antinociceptive effect of the clematis
gouriana roxb, International journal of
pharma research and development.
. Zeleke, B., A preliminary study of the
activity of Cheilanthes farinosa against
eczema, Directed studies paper
submitted in partial fulfillment of the
requirements for the degree of Bachelor
of Pharmacy, School of Pharmacy,
Addis Ababa University, 1993.
. Keys DJ, Chinese Herbs, the Botany,
Chemistry and Pharmacodynamics.
Third Press, Charlese. Tutle Company,
Tokyo, Japan, 1985, 159ă160.
. Yelisada E. and Kupeli E., Clematis
vitalba L. aerial part exhibits potent antiinflammatory,antinociceptive and
antipyretic effects, Journal of
Ethnopharmacology, 110(3), 2006, 504-
. Kirtikar KR, Basu BD. Indian Medicinal
Plants, Dehradun, India. Bishen
Mahendra Pal Singh, I, 1993, 3-7.
. Rajkumar N.S. and Damane M.M.
Elemental analysis of some herbal
plants used in the treatment of
cardiovascular diseases by NAA and
AAS, J. Radioanal Nucl. Chem., 219, 1
, 77-80.
. Kordali S, Cakir A, Zengin H, Duru ME,
Antifungal activities of the leaves of
three Pistacia species grown in Turkey,
Fitoterapia 2003, 74: 164 - 7.
. Villar A, Sanz MJ, Payo M. Hypotensive
effect of Pistacia lentiscus L.
International Journal Crude Drug Res.,
(1), 1987, 1 - 3.
. Benhammou N, Bekkara FA, Panovska
TK. Antioxidant and antimicrobial
activities of the Pistacia lentiscus and
Pistacia atlantica extracts, African
Journal Pharmacology, 2 (2), 2008, 22 -
. Sheshadri VS. Cucurbits. In: Vegetable
Crops in India, edited by Bose TK and
Som MG Naya Prokash, Calcutta, India,
. Som MG, Maity TK, Hazra P. Pointed
Gourd. In genetic improvement of
vegetable crops edited by Kalloo G and
Berg BO, Pergamon Press, Oxford, UK,
. Chopra RN, Nayar SL, Chopra IC.
Glossary of Indian Medicinal plants.
CSIR: New Delhi, 1956.
. Kirtikar KR, Basu BD. Indian Medicinal
Plants. Lalit Mohan Basu Publications,
Allahabad, 1980.
. Prajapathi ND, Purohit SS, Sharmi AK,
Kumar T. A Handbook of medicinal
plants. A complete source book,
Agrobios, Shyam Printing Press,
Jodhpur, 2003, 265.
. Kirtikar KR, Basu BD. Indian Medicinal
Plants, International book distributors,
Dehradun, India, 1, 1995.
. Pornpen Pramyothin, Patcharavadee
Samosorn, The protective effects of
Phyllanthus
. emblica Linn. Extract on ethanol induced
rat hepatic injury, journal of
Ethnopharmacology, 2006, 361-364.
. Bafna A.R., Mishra S. Effect of
methanolic extract of Achyranthes
aspera Linn on rifampicin induced
hepatotoxicity in rats. Ars. Pharm. 2004;
(4): 343-351.
. Karimulla S. k. Evaluation of antiulcer
activity of ochana obtusata in various
experimental models, International
journal of preclinical & pharmaceutical
research, 3, (1), 2012; 14-19..
