Anti-inflammatory and analgesic activity of different fractions of Boswellia serrata

Authors

  • A. Sharma Department of Pharmacognosy, Poona College of Pharmacy, Bharati Vidyapeeth University, Pune, 411038, INDIA.
  • S. Bhatia Department of Pharmacognosy, Poona College of Pharmacy, Bharati Vidyapeeth University, Pune, 411038, INDIA.
  • M. D. Kharya Dept. of Pharmaceutical, Sciences, Dr. Hari Singh Gour University, Sagar 470 003, INDIA.
  • V. Gajbhiye Dept. of Pharmaceutical, Sciences, Dr. Hari Singh Gour University, Sagar 470 003, INDIA.
  • Ganesh N Dept. of research, Jawaharlal Nehru Cancer Hospital & research Centre, Bhopal, INDIA.
  • A. G. Namdeo Department of Pharmacognosy, Poona College of Pharmacy, Bharati Vidyapeeth University, Pune, 411038, INDIA.
  • K. R. Mahadik Department of Pharmacognosy, Poona College of Pharmacy, Bharati Vidyapeeth University, Pune, 411038, INDIA.

Keywords:

Analgesic, Boswellia serrata, Inflammation, 5- lipoxygenase, Burseraceae

Abstract

The study was designed to investigate the anti-inflammatory and analgesic effect of different fractions of Boswellia serrata. The effect of different fractions of Boswellia serrata were studied using carrageenan induced paw edema, acetic acid induced writhing response, formalin induced pain, hot plate and tail flick method for studying anti-inflammatory and analgesic activity, respectively. The different fractions of B. serrata, essential oil (10 ml/kg), gum (100 mg/kg, resin (100 mg/kg) oleo-resin (100 mg/kg) and oleogum-resin (100 mg/kg) significantly reduces carrageenan induced inflammation in rats and shows analgesic activity, as determined by acetic acid induced writhing response, formalin induced pain, hot plate and tail flick method. The different fractions of B. serrata showed prompt antiinflammatory and analgesic activity due to the inhibition of 5-lipoxygenase enzyme.

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Published

09-02-2022

How to Cite

1.
A. Sharma, S. Bhatia, M. D. Kharya, V. Gajbhiye, Ganesh N, A. G. Namdeo, K. R. Mahadik. Anti-inflammatory and analgesic activity of different fractions of Boswellia serrata. ijp [Internet]. 2022 Feb. 9 [cited 2024 Jul. 15];2(1):94-9. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/23

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