Tumor inhibition and Cytotoxicity assay by aqueous extract of onion (Allium cepa) & Garlic (Allium sativum): an in-vitro analysis

Authors

  • Shilpa Shrivastava In-charge, Deptt. Of Research, Jawaharlal Nehru Cancer Hospital & Research Centre, Idgah Hills, Bhopal, INDIA.
  • N.Ganesh In-charge, Deptt. Of Research, Jawaharlal Nehru Cancer Hospital & Research Centre, Idgah Hills, Bhopal, INDIA.

Keywords:

Allium cepa, Allium sativum, B16F10 Melanom, cell lines, invitro culture

Abstract

The present study was aimed to investigate the effects of aqueous extract of four different varieties of Allium cepa (Onion) & Allium sativum (Garlic) on B16F10 Melanoma cell population by ex-vivo. For cytotoxicity assay, cellular micronucleus, apoptotic assay and cell viability assay were followed. Our results showed significant activity of garlic and onion as cytoprotective agents of normal cells and cytotoxicity agents for tumor cells. A significant decrease in Melanoma B16F10 cell population by crude extract was observed. Therefore, Allium cepa & Allium sativum might be a candidate for naturally healing the tumor.

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Published

09-02-2022

How to Cite

1.
Shilpa Shrivastava, N.Ganesh. Tumor inhibition and Cytotoxicity assay by aqueous extract of onion (Allium cepa) & Garlic (Allium sativum): an in-vitro analysis. ijp [Internet]. 2022 Feb. 9 [cited 2024 Jun. 17];2(1):80-4. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/21

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Original Research Articles