Pharmacognostic Studies and Antiinflammatory Activities of Clerodendrum Volubile P Beauv Leaf

Authors

  • Fred-Jaiyesimi Adediwura Department of Pharmacognosy, Faculty of Pharmacy Olabisi Onabanjo University, Sagamu Campus Ogun State, Nigeria
  • Adekoya Yewande Department of Pharmacognosy, Faculty of Pharmacy Olabisi Onabanjo University, Sagamu Campus Ogun State, Nigeria

Keywords:

anti-inflammatory, Clerodendrum volubile, macroscopy, microscopy, phytochemical screening

Abstract

Clerodendrum volubile P Beauv (Verbenaceae) is a climbing shrub used traditionally in the treatment of swelling, gout and venereal diseases. In this study, the microscopic, macroscopic, phytochemical analysis and anti-inflammatory activities were investigated using standard procedures. The results revealed the presence of alkaloids, flavonoids, saponins, anthraquinone and cardiac glycoside while the methanol extract, petroleum ether and ethyl acetate fractions exhibited significant (p<0.05) anti-inflammatory activities when compared to the effect of the reference drug Diclofenac sodium.

References

. Burkill HM. The useful plants of West

tropical Africa. Royal Botanic

Gardens, Kew, 1985; 1:319.

. Erukainure OL, Oke OV, Ajiboye AJ,

Okafor OY. Nutritional qualities and

Phytochemical constituents of

Clerodendrum volubile, a tropical

non-conventional vegetable. Inter

Food Res J 2011; 18(4): 1393 –

. Fleischer TC, Mensah AY, Oppong

AB and Mensah MLK, Dickson RA

and Annan K: Antimicrobial and

Antiiflammatory activities of

Clerodendrum splendens leaves.

Pharmacog Com, 2011; 1: 85 – 89.

. Harborne JB. Method of extraction

and isolation In. Phytochemical

Methods, Chapman and Hall,

London. Third edition 1998; 60-66.

. Evans WC. Pharmacognosy,

Saunders. London. Fifteenth edition

; p585

. Mukerjee PK. Morphological

Examinations. In: Quality Control of

herbal drugs. Business Horizons

Pharmaceutical Publishers. 2002;

-133.

. Wallis TE. A textbook of

Pharmacognosy. J and A Churchill

Ltd, London. Third edition 1967

. Lala PK. Lab Manuals of

Pharmacognosy. CSI Publishers

and Distributors, Calcutta Fifth

edition, 1993

. Akah PA, Nwambie A. Evaluation of

Nigerian traditional medicines. I:

Plants used for rheumatic

(inflammatory) disorders. J.

Ethnopharmacol 1994; 42: 179-182.

. Winter CA. Risley EA, Nuss GW.

Carrageenin-induced edema in hind

paw of the rats as an assay of antiinflammatory drugs. Proc. Soc. Exp.

Biol. Med., 1962; 111: 544 - 547

. Hess SM, Milonig RC. Inflammation.

In: Inflammation Mechanism and

Control, Lepow, I.H., P.S. Ward

(Eds.). Academic Press, New York,

USA, 1972; 1-12.

. Dinesh K, Pravin VB, Zulfikar AB,

Jeevan SD, Yogesh SK, Santosh

SB. Macroscopical and

Microscopical evaluation of leaves

of Clerodendrum inerme Gaertn.

Inter J Bio Med sci 2011; 2(1): 404

– 408.

. Devi VG, Vijayan C, John A,

Gopakumark K. Pharmacognostic

and Antioxidant studies on

Clerodendrum inerme and

identification of ursolic acid as

marker compound. Inter J Pharm

Pharm Sci 2011; 4(2): 145 – 148.

. Di Rosa M. Biological properties of

carrageenan. J. Pharm Pharmacol

; 24: 89-102.

. Di Rosa, M, Papaimitriou J,

Willioughy DA. A histopathological

and Pharmacological analysis of the

mode of action of non-steroidal and

anti- inflammatory drugs. J Pathol

; 105: 329-356.

. Vinegar R, Schreiber W, Hugo R.

Biphasic development of

carrageenin oedema in rats. J

Pharmacol Exp Ther 1969; 166: 96-

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Published

30-09-2012

How to Cite

1.
Fred-Jaiyesimi Adediwura, Adekoya Yewande. Pharmacognostic Studies and Antiinflammatory Activities of Clerodendrum Volubile P Beauv Leaf. ijp [Internet]. 2012 Sep. 30 [cited 2024 Dec. 23];4(3):414-8. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/196

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Original Research Articles