Haberlea rhodopensis (Friv.) reduces chromosomal aberrations in whole body irradiated rabbits

Authors

  • Svetlana Georgieva Dept. Genetics, Animal breeding and Reproduction, Trakia University, Stara Zagora 6000, Bulgaria
  • Borislav Popov Department of Molecular Biology, Immunology and Medical Genetics, Faculty of Medicine, Trakia University, Stara Zagora 6000, Bulgaria
  • Svetlin Tanchev Dept. Genetics, Animal breeding and Reproduction, Trakia University, Stara Zagora 6000, Bulgaria.
  • Deyana Hristova Dept. Genetics, Animal breeding and Reproduction, Trakia University, Stara Zagora 6000, Bulgaria.

Keywords:

chromosome aberrations, Haberlea rhodopensis, radioprotection

Abstract

Radioprotective effect of ethanolic extract of Haberlea rhodopensis have been studied by examining chromosome aberration in irradiated rabbits. Healthy adult New Zeland rabbits were injected intramuscularly (im) with 120 mg/kg body weight before and after irradiation or with double distilled water (DDW). They were exposed to whole body irradiation of 2.0 Gy gamma rays. After 24 h chromosomal aberrations were studied in the peripheral blood lymphocytes. Radiation (2.0 Gy) increased the number of aberrant cells from less than 3% in controls to almost 25%. Treatment with the total extract of Haberlea rhodopensis (HR) before and after irradiation resulted in a significant reduction in the percentage of aberrant metaphases as well as in the different types of aberration scored. Our results proved the ameliorating role of HR against radiation-induced chromosomal aberrations in rabbits.Further experimental studies using different cytogenetic and molecular biomarkers are needed to clarify the exact mechanisms of radioprotective action of the HR extract

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Published

30-09-2012

How to Cite

1.
Svetlana Georgieva, Borislav Popov, Svetlin Tanchev, Deyana Hristova. Haberlea rhodopensis (Friv.) reduces chromosomal aberrations in whole body irradiated rabbits. ijp [Internet]. 2012 Sep. 30 [cited 2024 Dec. 6];4(3):395-8. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/192

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