Hypolipidemic activity of Sesbania grandiflora in triton wr-1339 induced hyperlipidemic rats

Authors

  • A. Saravanakumar Pharmaceutical Sciences Discipline, Bio-technology Centre, Anna University, Coimbatore-641047, Tamilnadu, India.
  • S. Vanitha Department of Pharmaceutical Analysis, The Erode College of Pharmacy, Veppampalayam Pirivu, Erode-638112, Tamilnadu, India.
  • M. Ganesh Pharmaceutical Sciences Discipline, Bio-technology Centre, Anna University, Coimbatore-641047, Tamilnadu, India.
  • J.Jayaprakas Anti Rabies Division, Pasteur Institute of India, Coonoor, The Nilgiris- 643103, Tamilnadu, India.
  • N.M. Ramaswamy Pharmaceutical Sciences Discipline, Bio-technology Centre, Anna University, Coimbatore-641047, Tamilnadu, India.

Keywords:

Sesbania grandiflora, Hyperlipidemia, LDL, VLDL

Abstract

Hyperlipidemia is the greatest risk factor of coronary heart disease. Currently available hypolipidemic drugs have been associated with number of side effects. Herbal treatment for hyperlipidemia has no side effects and is relatively cheap and locally available. A literature claims that flavonoids can able to reduce the hyperlipidemia. Based on high flavonoid content in herbal, Sesbania grandiflora (SG) was selected and the present study focus on the anti-hyperlipidemic activity of aqueous extract of leaves of SG against triton induced hyperlipidemia in rats. SG administered a dose of 200µg/kg (p.o) to the triton induced hyperlipidemic rats. SG shows a significant decrease in the levels of serum cholesterol, phospholipid, triglyceride, LDL, VLDL and significant increase in the level of serum HDL at the dose of 200µg/kg (p.o) against Triton induced hyperlipidemic in rats. Aqueous extract of leaves of SG was investigated hypolipidemic activity on Triton induced hyperlipidemic profile. Aqueous extract fraction decreased serum level of total cholesterol by 69.72. On the other hand, aqueous extract of SG increased the serum HDL cholesterol level by 24.11. The reduction of LDL cholesterol level by aqueous extract was 30.31.

References

Grundy S M. Cholesterol and coronary heart

disease: a new era. J Am Med Assoc 1986;

: 2849-2858.

Davey Smith G. Cholesterol lowering and

mortality: the importance of considering

initial level of risk. Int. Med. J. 1993; 306:

-1373, Correction: 1648.

Saravanan R, Rajendra Prasad N, Pugalandi

KV. Effect of Piper betle leaf extract on

alcoholic toxicity in the rat brain. J. Med.

Food. 2003;6: 261-265.

Kaesancini AY, Krauss RM. Cardiovascular

disease and hyperlipidemia. Cur. Opi.

Lipidol. 1994; 5: 249-251.

Davey Smith G, Pekkanen J. Should there be a

moratorium on the use of cholesterol

lowering drugs? Br. Med. J. 1992; 304: 431-

Brown S L. Lowered serum cholesterol and

low mood. Br. Med. J. 1996; 313: 637-638.

Speight TM. In: Avery’s Drug treatment

Principles and Practice of clinical

Pharmacology and therapeutics. 1987, 3rd

Edition, ADIS press Ltd, p.599.

Berliner JA, Heinecke JW. The role of

oxidized lipoproteins in atherogenesis. Free

Radic. Biol. Med. 1996; 20: 707-727.

Takashi Suzuki, Yasuo Suzuki. Current topics

of lipid dynamics and pathobiology inmembrane lipid rafts. Biol. Pharm. Bull.

; 29: 1538-1541.

Ryan DH. Diet and exercise in the prevention

of diabetes. Int. J. Clin. Pract. 2003; 134: 28-

Anna Gramza, Jozef Korczak. (Camellia

sinensis L) as antioxidants in lipid systems.

Trends Food Sci. Tech. 2005; 16: 351-358.

Chopra RN, Nayer SL, Chopra IC. Glossary

of Indian Medicinal Plant. CSIR, New Delhi

, p.1224-1235.

A. Saravanakumar, K. Venkateshwaran,

J.Vanitha, V.S.Saravanan, M.Ganesh,

T.Sivakumar. Antibacterial activity of

methanolic extract of Sesbania grandiflora

(Fabaceae). Res. J. Pharma. Tech. 2008;1:67-

Singh R, Sidhu PS, Vadhera S, Sital JS,

Bhatia S. Extra-cellular invertase of

Rhizobium japonicum and its role in free

sugar metabolism in the developing root

nodules of Sesbania grandiflora. Physiol.

Plantarum. 1980; 48: 504-508.

Kirtikar KR, Basu BD. Indian Medicinal

Plants. Lalit Mohan Basu, 4, Leaders Road

Allahabad 1975, p.1061-1065.

Friedman M, Byers SO. Mechanism

underlying hypercholesterolemia induced by

triton WR-1339. Am. J. Physiol. 1957; 190:

-445.

Muramatsu K, Fukuyo M, Hara Y. Effect of

green Tea catechins on plasma cholesterol

level in cholesterol feed rats. J. Nutr. Sci.

Vitaminol. 1986; 56: 509-520.

Ding ZY, Chen Y, Zhou M, Fang YZ.

Inhibitory effect of green tea polyphenol and

murin on the oxidative modification of low

density lipoprotein. Clin. J. Pharmacol.

Toxicol. 1992; 6: 263-266.

Kellner A, Correll JW, Ladd AT. Sustained

hyperlipidemia induced in rabbits by means

of intravenously injected surface active

agents. J. of. Exp. Med. 1951; 93: 373-384.

Fiser RH, Denniston, Rindsig RB, Beisel

WR. Triglyceride secretion rates: use of

Triton in the rhesus monkey. J. of. Nutr.

; 104:223-226.

Schurr PE, Schultz JR, Parkinson TM. Triton

induced hyperlipidemia in rats as an animal

model for screening hypolidemic drugs.

Lipids. 1972; 7:69-74.

Ye-Yun Li, Chang-Jun Jiang, Xiao-Chun

Wan, Zheng-Zhu Zhang Da-Xiang Li.

Purification and partial characterization of bGlucosidase from fresh leaves of tea plants

(Camellia sinensis (L) O.Kuntze. Acta.

Biochim. Biophys. Sin. 2005; 37:364- 370.

Harbowy ME, Balentine DA. Tea chemistry.

Crit. Rev. Plant and Sci. 1997; 16: 415-480.

Otway S, Robinson DS. The effect of the

non-ionic detergent (Triton) on the removal

of triglyceride fatty acids from the blood of

the rats. J. of. Physiol. 1967; 190:309-319.

Khanna AK, Rizvi F, Chander R. Lipid

lowering activity of Phyllanthus niruri in

hyperlipidemic rats. J. of Ethnopharmacol.

; 82:19-22.

Del Bas JM, Fernandez-Larrea J, Blay M,

Ardevol A, Arola MJ, Blade C. Grape seed

procyanidins improve atherosclerotic risk

index and induce liver CYP7A1 and SHP

expression in healthy rats. FASEB. J. 2005;

:479-481.

Bruneton J. Elements de phytochimie et de

pharmacognosie, Technique &

Documentation Lavoisier, Paris, p.136-162.

Sochar M, Baquer NZ, Mclean P. Glucose

under utilization in Diabetes. Comparative

studies on the changes in the activities of

enzymes of glucose metabolism in rat kidney

and liver. Mol. Physiol. 1985; 7: 51-68.

Ji SK, Jung BJ, Chang WC, Sei CK.

Hypoglycemic and Antihyperlipidemic effect

of four Korean medicinal plants in alloxan

induced diabetic rats. Am. J. Biochem.

Biotech. 2006;2:154-160.

Chhanda Mallick, Rajkumar Maiti, Debidas

Ghosh. Comparative study on Antihyperglycemic and antihyperlipidemic effects of

separate and composite extract of seed of

Eugenia jambolana and root of Musa

paradisiaca in streptozotocin- induced

diabetic male albino rats. Ira. J. of Pharmacol.

Therapeu. 2006; 5: 27-33.

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Published

09-02-2022

How to Cite

1.
A. Saravanakumar, S. Vanitha, M. Ganesh, J.Jayaprakas, N.M. Ramaswamy. Hypolipidemic activity of Sesbania grandiflora in triton wr-1339 induced hyperlipidemic rats. ijp [Internet]. 2022 Feb. 9 [cited 2024 Oct. 15];2(1):52-8. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/18

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