Relaxant effect of Jatropha gossypiifolia L. on uterine smooth muscle

Authors

  • Antonio Marcus de Andrade Paes Universidade Federal do Maranhão Departamento de Ciências Fisiológicas Avenida dos Portugueses, 1966 Campus do Bacanga 65.080-805 São Luís (MA) – Brazil
  • Adriana Leandro Camara Universidade Federal do Maranhão Departamento de Ciências Fisiológicas Avenida dos Portugueses, 1966 Campus do Bacanga 65.080-805 São Luís (MA) – Brazil
  • Sônia Maria de Farias Freire Universidade Federal do Maranhão Departamento de Ciências Fisiológicas Avenida dos Portugueses, 1966 Campus do Bacanga 65.080-805 São Luís (MA) – Brazil
  • Marilene Oliveira da Rocha Borges Universidade Federal do Maranhão Departamento de Ciências Fisiológicas Avenida dos Portugueses, 1966 Campus do Bacanga 65.080-805 São Luís (MA) – Brazil

Keywords:

Jatropha gossypiifolia L., uterine smooth muscle, calcium influx and relaxation

Abstract

Jatropha gossypiifolia L. (Euphorbiaceae) is popularly known in Brazil as pião roxo and extensively used for hypotensive, spasmolytic and tocolytic purposes. In the present work, ethanolic extract and fractions from aerial parts of J. gossypiifolia L. were assayed for their effects on calcium-evoked uterine smooth muscle contraction. Rat uterus strips were incubated with ethanolic extract (0.1, 0.5 and 1.0 mg/ml), chloroformic fraction (0.25; 0.5 mg/ml) or aqueous fraction (0.25; 0.5 mg/ml). Ethanolic extract promoted a rightward displacement of calcium cumulative curves, as well as, reduced the maximal contractions in 27.3% and 80.3% (0.5 and 1.0 mg/ml, respectively). Clhoroformic fraction inhibited the responsiveness of uterine muscle to calcium causing the maximal contractile response to be reduced in 27.4 % and 45.1 %, respectively. On the other hand, these parameters were only slightly reduced in the presence of aqueous fraction. Taken together, our results suggest that ethanolic extract and fractions from J. gossypiifolia reduce calcium-evoked contractile response of the uterine smooth muscle, corroborating its ethnopharmacological application as tocolytic remedy.

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Published

30-09-2012

How to Cite

1.
Antonio Marcus de Andrade Paes, Adriana Leandro Camara, Sônia Maria de Farias Freire, Marilene Oliveira da Rocha Borges. Relaxant effect of Jatropha gossypiifolia L. on uterine smooth muscle. ijp [Internet]. 2012 Sep. 30 [cited 2024 Dec. 6];4(3):310-3. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/179

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Short Communication