Antitumor, antioxidant and antibacterial evaluation of new ligand of cinnemaldehyde and its Fe (III) and Mn (II) complexes

Authors

  • Taravat Talebi Department of Biology, University of Mohaghegh Ardabili, Ardabil, Iran
  • Pegah Namian Department of Biology, University of Mohaghegh Ardabili, Ardabil, Iran
  • Karimollah Ghasemi Germi Department of Biology, University of Mohaghegh Ardabili, Ardabil, Iran
  • Fahmideh shabani Department of Chemistry, Islamic Azad University, Young Researchers club, Ardabil Branch, Ardabil, Iran
  • Armin Talebi Department of pharmacy, school of pharmacy, Mazandaran university of medical sciences, Sari, Iran
  • Seyed Reza Mirhafez Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Keywords:

Cinnamomum zeylanicum, NI, metal complex, cytotoxic activity, antioxidant activity, antibacterial activity

Abstract

Cinnamomum zeylanicum is medicinal plant posse’s significant biological activities. In this study, we investigated biological properties of the ligand and metal complexes synthesized from herb of C.zeylanicum (cinnemaldehyde) by chemical reactions. N4 [(E, 2E)-3-Phenyl-2-propenylidene] isonicotinohydrazide abbreviated as NI were synthesized as ligand. Fe (III) and Mn (II) metal complexes of this ligand prepared. Characterization of the ligand and its complexes were made by microanalyses, 1H NMR, 13C NMR, FT-IR and UV–Visible spectroscopy. Cytotoxic, antioxidant and antibacterial activities of these compounds have been evaluated by MTT, DPPH, agar disc diffusion and agar dilution assays, respectively. These new compounds showed high Cytotoxic effect against K562, Jurkat and T47D cell lines. Our results showed that the metal complexes and their ligand, had weak antioxidant potential with RC50 value of 0.394, 0.724 and 1.429 mg/mL, respectively. The Fe (III) complex had the highest cytotoxic effects on K562, Jurkat and T47D with IC50 value of 86.12, 77.86, 118.52, respectively. The Fe (III) complex had the highest antibacterial activity and ligand and Mn (II) complex were in next levels.

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Published

30-06-2012

How to Cite

1.
Taravat Talebi, Pegah Namian, Karimollah Ghasemi Germi, Fahmideh shabani, Armin Talebi, Seyed Reza Mirhafez. Antitumor, antioxidant and antibacterial evaluation of new ligand of cinnemaldehyde and its Fe (III) and Mn (II) complexes. ijp [Internet]. 2012 Jun. 30 [cited 2024 Dec. 6];4(2):248-53. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/170

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Original Research Articles