Potent antitumor activity of Rubia cordifolia

Authors

  • Parag R. Patel Parul Institute of Pharmacy, Limda, Vadodara, India.
  • Bhuvan P. Raval K. J. College of Pharmacy,Vadasma-382708, North Gujarat, India.
  • Hamsraj A. Karanth Parul Institute of Pharmacy, Limda, Vadodara, India.
  • Vishal R. Patel Baroda college of Pharmacy, Limda, Vadodara, India.

Keywords:

Rubia cordifolia, Cell line, Anticancer

Abstract

Background: Cancer is a leading cause of death. Rubia cordifolia is a traditional ayurvedic medicine being used as a remedy for various ailments. Results: Dichloromethane fraction of Rubia cordifolia extract exhibited potent inhibition of human leukaemia cell line and human histolytic lymphoma cell line while was found to be lesser active against normal human kidney cells displaying safety for normal cells. Conclusion: Rubia cordifolia can be a source of potent pharmacophore for treatment of disease like cancer.

References

Freshney RI. Culture of animal cells, A

manual of basic technique, 5th edition,

Wiley-Liss; p. 200-201, 209-211, 213-214,

, 328-332, 335-338, 359-370, 508.

Lieberman MM, Patterson ML, Moore RE. In

vitro bioassays for anticancer drug screening:

effects of cell concentration and other assay

parameters on growth inhibitory activity

Cancer Letters 2001; 173:21–29.

Balis FM. Evolution of anticancer drug

discovery and the role of cell-based

screening, Jrnl of the Natl can inst 2002;

:78-79.

Cell Proliferation Kit II (XTT) 2005, Roche

Diagnostics GmbH, Roche Applied Science,

Mannheim, Germany

Akbar MA, Ahamed R, Alam DK, Ali MS. In

Vitro Cytotoxic Properties of Ethanolic

Extracts of Various Parts of Swietenia

Mahagoni, Eurpan Jrnl of Scientific Res

; 32: 541-544.

Rao GV, Kumar S, Islam M, Mansour SE.

Folk medicines for anticancer therapy-a

current status, Cancer Therpy 2008; 6: 913-

Downloads

Published

09-02-2022

How to Cite

1.
Parag R. Patel, Bhuvan P. Raval, Hamsraj A. Karanth, Vishal R. Patel. Potent antitumor activity of Rubia cordifolia. ijp [Internet]. 2022 Feb. 9 [cited 2024 Jun. 16];2(1):44-6. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/16

Issue

Section

Original Research Articles