Potent antitumor activity of Rubia cordifolia
Keywords:
Rubia cordifolia, Cell line, AnticancerAbstract
Background: Cancer is a leading cause of death. Rubia cordifolia is a traditional ayurvedic medicine being used as a remedy for various ailments. Results: Dichloromethane fraction of Rubia cordifolia extract exhibited potent inhibition of human leukaemia cell line and human histolytic lymphoma cell line while was found to be lesser active against normal human kidney cells displaying safety for normal cells. Conclusion: Rubia cordifolia can be a source of potent pharmacophore for treatment of disease like cancer.
References
Freshney RI. Culture of animal cells, A
manual of basic technique, 5th edition,
Wiley-Liss; p. 200-201, 209-211, 213-214,
, 328-332, 335-338, 359-370, 508.
Lieberman MM, Patterson ML, Moore RE. In
vitro bioassays for anticancer drug screening:
effects of cell concentration and other assay
parameters on growth inhibitory activity
Cancer Letters 2001; 173:21–29.
Balis FM. Evolution of anticancer drug
discovery and the role of cell-based
screening, Jrnl of the Natl can inst 2002;
:78-79.
Cell Proliferation Kit II (XTT) 2005, Roche
Diagnostics GmbH, Roche Applied Science,
Mannheim, Germany
Akbar MA, Ahamed R, Alam DK, Ali MS. In
Vitro Cytotoxic Properties of Ethanolic
Extracts of Various Parts of Swietenia
Mahagoni, Eurpan Jrnl of Scientific Res
; 32: 541-544.
Rao GV, Kumar S, Islam M, Mansour SE.
Folk medicines for anticancer therapy-a
current status, Cancer Therpy 2008; 6: 913-
