Evaluation of Hepatoprotective activity of fruits of Sesbania grandiflora L. Pers against thiocetamide and ranitidine induced hepatotoxicity in rats
Keywords:
Hepatoprotective, Ranitidine, Sesbania grandiflora and ThioacetamideAbstract
The Petroleum ether extract of Sesbania grandiflora L. pers fruits showed a significant dose dependent (100mg, 200mg/kg p.o.) protective effect against thioacetamide and ranitidine induced hepatotoxicity in Wistar albino rats. The degree of protection was measured by using biochemical parameters like Serum glutamic oxaloacetic transaminase (SGOT), Serum glutamic pyruvic transaminase (SGPT), Alkaline phosphatase (ALP), Total bilirubin (BRN), Total Cholesterol (TC), Total protein and Histopathological alterations. The fruit extract completely prevented the toxic effects of Thioacetamide and Ranitidine on the above serum parameters. The petroleum ether extract of Sesbania grandiflora L. pers fruits produced significant protection.
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