Pharmacological and Toxicological Effects of Aqueous Acetone Extract of Sida alba L. (Malvaceae) in Animals Model

Authors

  • K.Konaté Laboratoire de Biochimie et Chimie Appliquées (LABIOCA), UFR/SVT, Université de Ouagadougou, 09 BP 848 Ouagadougou 09, Burkina Faso
  • M.Ouédraogo aboratoire de Physiologie Animale, UFR/SVT, Université de Ouagadougou, 09 BP 848 Ouagadougou 09, Burkina Faso.
  • J. F. Mavoungou Institut de Recherche en Ecologie Tropicale (IRET/CENAREST). BP : 13354 Libreville-Gabon.
  • A.N.Lepengué Laboratoire de Physiologie Animale, Electrophysiologie et de Pharmacologie, Faculté des Sciences, Université des Sciences et Techniques de Masuku, Franceville-Gabon.
  • A.Souza Laboratoire de Physiologie Animale, Electrophysiologie et de Pharmacologie, Faculté des Sciences, Université des Sciences et Techniques de Masuku, Franceville-Gabon.
  • B.M’Batchi Laboratoire de Phytopathologie, UFR Agrobiologie, Faculté des Sciences, Université des Sciences et Techniques de Masuku, BP 943 Franceville-Gabon.
  • O.G.Nacoulma Laboratoire de Biochimie et Chimie Appliquées (LABIOCA), UFR/SVT, Université de Ouagadougou, 09 BP 848 Ouagadougou 09, Burkina Faso.

Keywords:

Sida alba, LD50, toxicity, Biological parameters, mice and Wistar rats

Abstract

The present study was conducted to evaluate the pharmacological and toxic effects of aqueous acetone extract of Sida alba L. a Malvaceae species, in mice Swiss and albinos Wistar rats. In acute toxicity test, mice received doses of this extract by intraperitoneal route with LD50 value of 3200 mg/kg. In sub-acute toxicity test, albinos Wistar rats were treat by gavage during 28 days with different doses of aqueous acetone extracts of Sida alba L., (75, 100 and 150 mg/kg). About to the pharmacological properties, the results varied widely in dose of extract and weight of rats and did not show clinical correlations. We undertook this study of extracts in order to provide a scientific basis for the traditional use of Sida alba L., in traditional medicine particularly to treat hepatitis B. Our results of this study appeared to show the safety of acute and sub-acute toxicities of extract from Sida alba L., which can therefore be continuously used with safety in traditional medicine. Statistical studies revealed that there is a low significant difference in body and organ weights, and biological parameters between control group and the treated assay groups (p<0.01 or p<0.05).

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Published

31-03-2012

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1.
K.Konaté, M.Ouédraogo, J. F. Mavoungou, A.N.Lepengué, A.Souza, B.M’Batchi, O.G.Nacoulma. Pharmacological and Toxicological Effects of Aqueous Acetone Extract of Sida alba L. (Malvaceae) in Animals Model. ijp [Internet]. 2012 Mar. 31 [cited 2024 Dec. 23];4(1):40-7. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/145

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