Hepatoprotective Activity of Chenopodium Album Linn. Against Alcohol Induced Liver Damage

Authors

  • Vijay Nigam Department of Pharmacognosy, SRET College of Pharmacy, P.O. Tipper, Distt: Hamirpur (H.P.)
  • Padmaa M Paarakh Department of Pharmacognosy The Oxford College of Pharmacy 6/9, I Cross, Begur Road Hongasandra. Bangalore 560068

Keywords:

Chenopodium album Linn, hepatoprotective activity, alcohol; chronic hepatitis model, serum biochemical assessment, histopathology

Abstract

Dried aerial parts of Chenopodium album Linn. (Chenopodiaceae) are used in variety of diseases in traditional Indian system of medicine including hepatic ailments. The aim of present study was to validate hepatoprotective activity of aerial parts of Chenopodium album Linn using alcohol as chronic hepatitis model. Alcoholic [ALCA] and aqueous [ AQCA] extracts of the aerial parts of Chenopodium album at the doses of 200 and 400 mg/Kg were evaluated for hepatoprotective activity against alcohol induced hepatotoxicity using biochemical markers and by histopathological method. The aqueous extract at a dose of 400 mg/kg was found to be more potent when compared to Silymarin. ALCA and AQCA [200 & 400 mg/Kg] showed significant hepatoprotective activity against alcohol induced hepatotoxicity as evident by restoration of serum transaminases, alkaline phosphatase and bilirubin content. Histopathology of the liver tissue further confirmed the reversal of damage induced by hepatotoxin.Present study showed that the alcoholic and aqueous extracts of Chenopodium album significantly restore physiological integrity of hepatocytes. Aqueous and alcoholic extract did not show any sign of toxicity up to oral dose of 5 g/Kg in mice.

References

Petri WA. Antimicrobial agents. In : Gilman

AG, Hardman JG, Limbird LE, Editor. The

Pharmacological Basis of Therapeutics. Tenth

ed. New York: McGraw-Hill publication

Corporation; 2001;p.1189-1193.

Nadeem M, Dandia PC, Pasha KV, Imran M,

Balani DK, Vohora SB. Hepatoprotective

activity of Solanum nigrum fruits.

Fitoterap.1997;LXVIII: 245-251.

Nedialkova ZK, Nedialkov PT, Nikolov SD.

The genus Chenopodium: Phytochemistry,

Ethno pharmacology and Pharmacology.

Phcog Rev.2009;3(6):280-306.

Anonymous. The Wealth of India (Raw

Materials), Vol. 3, New Delhi: Publication and

Information Directorate, CSIR; 2001;p464-469.

Warrier PK. Indian Medicinal Plants- A

Compendium of 500 Species, Vol. 2, Chennai:

Orient Longman Pvt Ltd; 2001;p.61-62.

Agarwal SS, Yamrekar BP, Paridhavi M.

Clinical Useful Herbal Drug, New Delhi: Ahuja

Publishing House; 2005;p.10-12.

Panda H. Handbook on Medicinal Herbs with

Uses. New Delhi: Asia Pacific Business Press;

;p.325-26.

Pramila K, Neetu S, Anju R. Medicinal plants

used in traditional health care system

prevalent in Western Himalaya. Indian J

Traditional Knowled. 2006;5(3):300-309.

Khare CP. Indian Medicinal Plants, New Delhi:

Springer International Publication; 2007;p141-

Rastogi RP, Mehrotra BN. Compendium of

Indian Medicinal Plants, Vol. 3, reprint edn.

Lucknow: CDRI; 1998;p.162-63.

Della Greca M, D’Abrosca B, Fiorentino A,

Previtera H, Zarrelli A. Structure elucidation

and phytotoxicity of ecdysteroids from

Chenopodium album. Chem Biodivers.

;2(4):457-62.

Della Greca M, Di Marino C, Zarrelli A,

D’Abrosca B. Isolation and phytotoxicity of

apocarotenoids from Chenopodium album. J

Nat Prod. 2004;67(9):1492-5.

Cutillo F, D’Abrosca B, Della Greca M, Zarrelli

A. Chenoalbicin, a novel cinnamic acid amide

alkaloid from Chenopodium album. Chem

Biodivers.2004;1(10):1579-83.

Cutillo F, Della Greca M, Gionti M, Previtera H,

Zarrelli A. Phenol and lignans from

Chenopodium album. Phytochemical Anal.

;17(5):344-9.

Jhade D, Padmaa MP, Usha G. Isolation of

phytoconstituents from the leaves of

Chenopodium album Linn. Journal of

Pharmacy Res. 2009;2(7):1192-1193.

Dai Y, Ye WC, Wang ZT, Mastuda H, Kubo M,

But PP. Antiprurutic and antinociceptive effect

of Chenopodium album L in mice. J

Ethnopharmacol. 2002;81(2):245-50.

Jabbar A, Zaman MA, Labal Z, Yaseen M,

Shamin A. Anthelmintic activity of

Chenopodium album L and Caesalpinia crista

L against trichostrongylid nematodes of sheep.

J Ethnopharmacol. 2007;114(1):86-91.

Kumar S, Biswas S, Mandal D, Roy HN,

Chakraborty S, Kabir SN. Chenopodium album

seed extract: a potent sperm immobilizing

agent both in vivo and in vitro. Contraception.

;75(1):71-8.

Vijay N, Padmaa MP. Antibacterial activity of

aerial parts of Chenopodim album Linn.

Journal of Pharmaceutical Research and

Clinical Practice, 2011;3(1):167-89.

Vijay N, Padmaa MP. Anti-ulcer Effect of

Chenopodium album Linn. against gastric

ulcers in rats. International Journal of

Pharmaceutical Sciences and Drug Res.

;3(4):319-322.

Vijay N, Padmaa MP. Hepatoprotective activity

of Chenopodium album Linn. against

paracetamol induced liver damage.

Pharmacologyonline 2011;3:312-328.

Gujrati V, Patel N, Rao VN, Nandkumar K,

Gouda TS, Shalam M, Kumar S.

Hepatoprotective activity of alcoholic and

aqueous extracts of leaves of Tylophora

indica (Linn.) in rats. Indian J Pharmacol.

;38(1):43-47.

Vogel WH, Scholkens BA, Sandow J, Muller

G. Drug Discovery and Evaluation;

Pharmacological Assay. Second ed. Berlin:

Springer-Verlag; 2002;p.906-944.

Amin A, Nanji MD, Samuel W, French MD.

Animal Models of Alcoholic Liver Disease—

Focus on the Intragastric Feeding Model.

Alcohol Research and Health.2003;27(4):325-

Prajapati ND, Purohit SS, Sharma AK, Kumar

T. A Handbook of Medicinal Plant. Jodhpur:

Agrobios; 2003;p.203-15.

Fromenty B, Pessayre D. Impaired

mitochondrial function in microvesicular

steatotis. Effect of drugs, ethanol, hormones

and cytokines. J Hepatol. 1997;26:43-53.

McClain CJ, Kromhount JP. Protestation of

acetaminophen hepatotoxicity by alcohol.

JAMA. 1980;244:251-3.

Seeff LB, Adler E. Acetaminophen

hepatotoxicity in alcoholics. A therapeutic

misadventure. Ann Int Med. 1986;104:399-

Fattah MA, Hasan AGA, Hamamy MI, Essam

AS. Antioxidant and hepatoprotective activity

of Eucalyptus maculata. Med Sci Monit.

;11:426-31.

Kinjo J, Hitoshi M, Tsuchihashi R, Korematsu

Y, Miyakoshi M, Murakami M, et al.

Hepatoprotective constituents in plants 15:

protective effects of natural-occurring

flavonoids and miscellaneous phenolic

compounds as determined in a HepG2 cell

cytotoxicity assay. J Nat Med. 2005;23:36-41.

Downloads

Published

31-12-2011

How to Cite

1.
Vijay Nigam, Padmaa M Paarakh. Hepatoprotective Activity of Chenopodium Album Linn. Against Alcohol Induced Liver Damage. ijp [Internet]. 2011 Dec. 31 [cited 2024 Jun. 12];3(4):511-23. Available from: https://ijp.arjournals.org/index.php/ijp/article/view/133

Issue

Section

Original Research Articles